Pathogen News and Research

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New way to deliver potential HIV vaccine using mRNA technology

Using mRNA technology like that in the COVID-19 vaccines, researchers have demonstrated a successful way to deliver a potential HIV vaccine, researchers at Duke Human Vaccine Institute report.

15 Mar 2022

Researchers identify a potential new test for early diagnosis of Lyme disease

For scientists and clinicians alike, one of the Holy Grails for successfully treating and curing Lyme disease is developing tests that identify the disease sooner, show when people are cured of infection, and can diagnose reinfection.

15 Mar 2022

Contact tracing data from the first COVID-19 pandemic wave in Shandong Province, China

Researchers evaluated SARS-CoV-2 transmission risks in different contact settings for prioritizing disease control from potential super-spreaders and their contacts.

15 Mar 2022

Using mRNA to introduce gene editor into human muscle stem cells

Mutations that lead to muscle atrophy can be repaired with the gene editor CRISPR-Cas9. A team led by ECRC researcher Helena Escobar has now introduced the tool into human muscle stem cells for the first time using mRNA, thus discovering a method suitable for therapeutic applications.

14 Mar 2022

NIH launches Phase 1 clinical trial evaluating three experimental mRNA HIV vaccines

The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, has launched a Phase 1 clinical trial evaluating three experimental HIV vaccines based on a messenger RNA (mRNA) platform—a technology used in several approved COVID-19 vaccines.

14 Mar 2022

Pangolins confiscated from illegal wildlife trade in Viet Nam host SARS-CoV-2 related coronaviruses

A new study in the journal Frontiers in Public Health led by scientists from the Wildlife Conservation Society confirms that pangolins confiscated from the illegal wildlife trade in Viet Nam host SARS-CoV-2 related coronaviruses.

11 Mar 2022

Mice study shows how to improve long-term effectiveness of TB vaccine

Briefly blocking a key molecule when administering the only approved vaccine for tuberculosis vastly improves long-term protection against the devastating disease in mice, researchers from Texas Biomedical Research Institute report this week in the Journal of Immunology.

11 Mar 2022

Study shows the mutations leading to omicron variant did not help virus escape recognition by T cells

People who gained immunity - either through vaccination or exposure - against the original strain of SARS-CoV-2, the virus that causes COVID-19, also are likely to have some protection against the pathogen's omicron variant.

11 Mar 2022

Pain neuron-derived peptide protects mice from endotoxic death by enhancing brain ATP production

Sepsis is a high-mortality disease that arises when the body's immune reaction to pathogens causes multi-organ defects.

9 Mar 2022

Utilizing UV direct irradiation to combat airborne pathogens such as SARS-CoV-2

Researchers describe a method to safely sanitize an occupied room using ultraviolet (UV)-C radiation.

8 Mar 2022

Scientists predict structure of SARS-CoV-2 frameshifting pseudoknot

Researchers recently unveiled the structure of programmed -1 ribosomal frameshifting pseudoknot of SARS-CoV-2.

8 Mar 2022

CD4 T-cell immunity active six months into COVID-19 convalescence

A new paper explores the presence of CD4 T-cell-mediated adaptive immunity against SARS-CoV-2 in late convalescence.

6 Mar 2022

Aldosterone levels undetectably low in hospitalized COVID-19 patients

A new study reports finds very low aldosterone levels in a subset of COVID-19 patients.

6 Mar 2022

Effectiveness of mRNA vaccines, antibody treatment reduced by all three omicron subvariants

Only one currently authorized antibody treatment retains its activity against all Omicron subvariants, according to new research by scientists at Columbia University and the University of Hong Kong.

3 Mar 2022

Whole-genome sequencing project sheds new light on the diversity of Candida glabrata

New research from the University of Exeter reports the largest ever whole-genome sequencing project for the potentially fatal yeast infection Candida glabrata from hospitals across Scotland.

3 Mar 2022

Understanding the evolutionary mutational patterns of chronic SARS-CoV-2 infection

In a new study, researchers elucidated the factors driving adaptive evolution in chronic SARS-CoV-2 infections.

2 Mar 2022

Using AI to detect antibiotic resistance

In this interview, we speak to Professor Karsten Borgwardt and Professor Adrian Egli about their latest research that used AI to predict antibiotic resistance.

1 Mar 2022

Mechanisms leading to Parkinson's disease following SARS-CoV-2 infection

In a recent study posted to the bioRxiv* preprint server, researchers demonstrated the impact of an amyloidogenic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) protein fragment named SFYVYSRVK (SK9) on the α-synuclein (aS) monomers and fibrils, a potential risk factor for Parkinson's disease.

28 Feb 2022

Scientists discover an innate form of immunological memory in the intestine

The innate immune system plays a crucial role in regulating host-microbe interactions, and especially in providing protection against pathogens that invade the mucosa.

28 Feb 2022

Antibiotic stewardship programs help long-term care facilities to reduce unnecessary antibiotic use

In early 2021, researchers at Johns Hopkins Medicine and NORC at the University of Chicago showed that the Agency for Healthcare Research and Quality (AHRQ) Safety Program for Improving Antibiotic Use — a comprehensive system they developed to assist health care institutions with establishing and operating antibiotic stewardship programs (ASPs) — successfully helped more than 400 U.S. hospitals ensure that patients only received antibiotics when needed, and then, only in the correct amounts and for the prescribed dosage period.

28 Feb 2022

Pathogen News and Research

New way to deliver potential HIV vaccine using mRNA technology

Researchers identify a potential new test for early diagnosis of Lyme disease

Contact tracing data from the first COVID-19 pandemic wave in Shandong Province, China

Using mRNA to introduce gene editor into human muscle stem cells

NIH launches Phase 1 clinical trial evaluating three experimental mRNA HIV vaccines

Pangolins confiscated from illegal wildlife trade in Viet Nam host SARS-CoV-2 related coronaviruses

Mice study shows how to improve long-term effectiveness of TB vaccine

Study shows the mutations leading to omicron variant did not help virus escape recognition by T cells

Pain neuron-derived peptide protects mice from endotoxic death by enhancing brain ATP production

Utilizing UV direct irradiation to combat airborne pathogens such as SARS-CoV-2

Scientists predict structure of SARS-CoV-2 frameshifting pseudoknot

CD4 T-cell immunity active six months into COVID-19 convalescence

Aldosterone levels undetectably low in hospitalized COVID-19 patients

Effectiveness of mRNA vaccines, antibody treatment reduced by all three omicron subvariants

Whole-genome sequencing project sheds new light on the diversity of Candida glabrata

Understanding the evolutionary mutational patterns of chronic SARS-CoV-2 infection

Using AI to detect antibiotic resistance

Mechanisms leading to Parkinson's disease following SARS-CoV-2 infection

Scientists discover an innate form of immunological memory in the intestine

Antibiotic stewardship programs help long-term care facilities to reduce unnecessary antibiotic use

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