Proliferation News and Research

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Phase 1 open-label trial shows SARS-CoV-2 DNA vaccine induces durable immune response

The efficacy and safety of a DNA-based vaccine are investigated, finding that the unique vaccine imparts a robust and long-lasting immunogenic response.

15 Oct 2021

Experts review progress in using photobiomodulation therapy to treat diverse brain disorders

Photobiomodulation (PBM) offers exciting opportunities for improving the life of patients with a diverse range of brain disorders.

14 Oct 2021

Impact of BRCA1 mRNA expression on survival of patients breast and colorectal cancer

Oncotarget published "Opposing effects of BRCA1 mRNA expression on patient survival in breast and colorectal cancer and variations among African American, Asian, and younger patients" which reported that LMNB2 is a chromatin remodeling protein that also plays a role in eukaryotic cell proliferation by organizing the nuclear membrane during mitosis.

13 Oct 2021

Characterization of circulating neutrophils from hospitalized COVID-19 patients

A new preprint deals with the characterization of neutrophil phenotypes in an attempt to provide biomarkers that can predict severe disease in patients hospitalized with COVID-19.

8 Oct 2021

Study reveals the trends in recreational ketamine use and availability in the U.S.

Recreational ketamine use and availability of the drug have increased in recent years, but it remains an uncommon drug used by less than 1 percent of people in the U.S., according to a new study published in the American Journal of Public Health.

7 Oct 2021

Deadly subtype of T-cell lymphoma harbors unique mutations

An especially deadly subtype of T-cell lymphoma is distinguished by unique mutations in a specific protein signaling pathway, according to a study published in the journal Blood.

7 Oct 2021

Critical function of IL-7 in diagnosis, prognosis, and treatment of COVID-19 patients

In this review, researchers summarized the therapeutic and pathogenic role of IL-7 in patients with COVID-19 and examined the promising role of IL-7 as a vaccine adjuvant.

7 Oct 2021

Enisamium shows potential as antiviral therapy for COVID-19

Researchers studied the effect of enisamium on the growth and proliferation of Caco-2 and normal human bronchial epithelial cells.

6 Oct 2021

Study identifies specific small RNA molecule that can reduce levels of cancer-promoting gene

In a recent study published in CANCER RESEARCH , a team led by researchers at Tokyo Medical and Dental University (TMDU) identified a specific small RNA molecule, called a microRNA (miRNA or miR), that has the potential to be used as an anti-cancer therapeutic.

5 Oct 2021

Cysteamine inhibits SARS-CoV-2 variants of concern in vitro

Researchers in the United States have shown that a compound currently used to treat cystinosis exhibits broad antiviral activity against variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

5 Oct 2021

Hollings Cancer Center researcher awarded NCI grant to pursue early investigator studies in leukemia

MUSC Hollings Cancer Center researcher Haizhen (Jen) Wang, Ph.D., was awarded a five-year $344,000 per year grant by the National Cancer Institute to pursue her early investigator studies in leukemia.

5 Oct 2021

Cancer drug can restore memory and cognitive function in mice with Alzheimer’s symptoms

A drug commonly used to treat cancer can restore memory and cognitive function in mice that display symptoms of Alzheimer's disease, new UBC research has found.

5 Oct 2021

Glycerin helps calm the red itchy patches in psoriasis model

Patients with psoriasis have reported that glycerin, an inexpensive, harmless, slightly sweet liquid high on the list of ingredients in many skin lotions, is effective at combatting their psoriasis and now scientists have objective evidence to support their reports.

4 Oct 2021

Aquaporin 5 induction may be a potential therapy to accelerate resurfacing of corneal defects

Corneal defects often heal themselves, but serious injuries that are left untreated can result in inflammation, infection, ulceration and even blindness.

30 Sep 2021

Novel small-molecule therapy shows promise against deadly pediatric leukemia

Mount Sinai researchers have developed a therapy that shows promise against a deadly pediatric leukemia. The small-molecule therapy was highly effective in fighting a type of acute myeloid leukemia in both in vitro and in vivo experiments, according to research published in Science Translational Medicine in September.

29 Sep 2021

New analysis reveals distinct differences between molecular profiles of 3D and 2D cultured cells

Oncotarget published "Comparative microsomal proteomics of a model lung cancer cell line NCI-H23 reveals distinct differences between molecular profiles of 3D and 2D cultured cells" which reported that to ascertain phenotypical differences between these two distinct culture conditions, these authors carried out a comparative proteomic analysis of a membrane fraction obtained from 3D- and 2D-cultured NSCLC model cell line NCI-H23.

29 Sep 2021

Research provides the basis for an additional novel immunotherapy for multiple myeloma patients

Oncotarget published "Multipeptide stimulated PBMCs generate TEM/TCM for adoptive cell therapy in multiple myeloma" which reported that Multiple Myeloma patients suffer disease relapse due to the development of therapeutic resistance. Increasing evidence suggests that immunotherapeutic strategies can provide durable responses.

29 Sep 2021

Researchers create an integrated pipeline for performing genetic screening studies

Today's genetic engineers have a plethora of resources at their disposal: an ever-increasing number of massive datasets available online, highly precise gene editing tools like CRISPR, and cheap gene sequencing methods. But the proliferation of new technologies has not come with a clear roadmap to help researchers figure out which genes to target, which tools to use, and how to interpret their results. So, a team of scientists and engineers at Harvard's Wyss Institute for Biologically Inspired Engineering, Harvard Medical School (HMS), and the MIT Media Lab decided to make one.

28 Sep 2021

Scientists discover novel therapeutic strategy for FLT3-ITD-positive acute myeloid leukemia

A new type of targeting chaperon protein HSP70 inhibitor QL47 was recently discovered by a team led by Prof. LIU Qingsong from the Hefei Institutes of Physical Science of the Chinese Academy of Sciences to treat FLT3-ITD-positive acute myeloid leukemia (AML).

27 Sep 2021

Researchers discover potential Achilles heel of pediatric acute myeloid leukemia

Researchers at Baylor College of Medicine and Texas Children's Hospital have uncovered a potential Achilles heel of acute myeloid leukemia (AML) in children that could lead to new treatments for this devastating disease.

23 Sep 2021

Proliferation News and Research

Phase 1 open-label trial shows SARS-CoV-2 DNA vaccine induces durable immune response

Experts review progress in using photobiomodulation therapy to treat diverse brain disorders

Impact of BRCA1 mRNA expression on survival of patients breast and colorectal cancer

Characterization of circulating neutrophils from hospitalized COVID-19 patients

Study reveals the trends in recreational ketamine use and availability in the U.S.

Deadly subtype of T-cell lymphoma harbors unique mutations

Critical function of IL-7 in diagnosis, prognosis, and treatment of COVID-19 patients

Enisamium shows potential as antiviral therapy for COVID-19

Study identifies specific small RNA molecule that can reduce levels of cancer-promoting gene

Cysteamine inhibits SARS-CoV-2 variants of concern in vitro

Hollings Cancer Center researcher awarded NCI grant to pursue early investigator studies in leukemia

Cancer drug can restore memory and cognitive function in mice with Alzheimer’s symptoms

Glycerin helps calm the red itchy patches in psoriasis model

Aquaporin 5 induction may be a potential therapy to accelerate resurfacing of corneal defects

Novel small-molecule therapy shows promise against deadly pediatric leukemia

New analysis reveals distinct differences between molecular profiles of 3D and 2D cultured cells

Research provides the basis for an additional novel immunotherapy for multiple myeloma patients

Researchers create an integrated pipeline for performing genetic screening studies

Scientists discover novel therapeutic strategy for FLT3-ITD-positive acute myeloid leukemia

Researchers discover potential Achilles heel of pediatric acute myeloid leukemia

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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