Proliferation News and Research

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Severe COVID-19 is associated with expansion of immature myeloid cells and inflammation

A team of scientists in Ireland recently identified certain immune markers that can predict the progression of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection to severe coronavirus disease 2019 (COVID-19). Early detection of these predictive markers can facilitate therapeutic decision-making prior to peak severity.

7 Sep 2021

Novel assay helps identify factors that can convert normal cells into liver cancer cells

Researchers at the University of Helsinki could show for the first time that normal human fibroblast cells can be converted to specific cancer cells using only factors that are commonly detected in actual human patients.

7 Sep 2021

Newly discovered cell type makes survivors of sepsis more vulnerable to infections

Sepsis is the leading cause of death in Brazil's intensive care units (ICUs). Among patients who progress to the severe form of the disease, 40% die, and the survivors often suffer from cardiovascular and neurological complications, as well as a significant decline in immunity lasting for years after they are discharged from hospital.

2 Sep 2021

Impact of neoadjuvant concurrent chemoradiation on exosomal markers expression in colorectal cancer

Oncotarget published "The impact of neoadjuvant concurrent chemoradiation on exosomal markers (CD63 and CD9) expression and their prognostic significance in patients with rectal adenocarcinoma" which reported that the impact of neoadjuvant concurrent chemoradiation on exosomal markers expression and their prognostic significance in patients with rectal adenocarcinoma are yet to be explored.

1 Sep 2021

Defined & Controllable Extracellular Matrix for Cell Culture

Biochemically defined and animal-free - Mussel Adhesive Protein based matrix (MAPtrix™) from AMSBIO provides a highly defined and controllable recombinant extracellular matrix (ECM) for cell culture, which can be tailored to the specific needs of particular cell types.

From AMS Biotechnology 1 Sep 2021

New model shows how dysfunction in the air sacs initiates fibrotic cascade

Idiopathic pulmonary fibrosis (IPF) is the most common and severe form of lung disease characterized by relentless scarring leading to death within an average of four years from the time of diagnosis.

31 Aug 2021

New compounds offer a two-for-one punch to fight estrogen-sensitive breast cancer

A set of compounds developed by scientists at Scripps Research in Florida target estrogen-sensitive breast cancer cells in new ways, potentially creating better options for patients with treatment-resistant cancers.

31 Aug 2021

DNMT2/TRDMT1 gene knockout may potentiate adverse effects related to drug-induced senescence

Aging-US published "The lack of functional DNMT2/TRDMT1 gene modulates cancer cell responses during drug-induced senescence" which reported that cellular senescence may be a side effect of chemotherapy and other anti-cancer treatments that may promote inflammation and paracrine secondary senescence in healthy tissues.

31 Aug 2021

Researchers study the role of low-density granulocytes in COVID-19

Information on granulocytes helps to understand mechanisms associated with covid-19 and other infectious diseases. Such information also promotes the development of better diagnostic methods and therapies.

30 Aug 2021

Combination therapy disables PI3K/Akt/mTOR pathway and induces apoptosis in carcinoid syndrome

Oncotarget published "Next-generation multimodality of nutrigenomic cancer therapy: sulforaphane in combination with acetazolamide actively target bronchial carcinoid cancer in disabling the PI3K/Akt/mTOR survival pathway and inducing apoptosis" which reported that microscopic imaging, immunocytochemistry, wound healing assay, caspase-cleaved cytokeratin 18 CytoDeath ELISA assay, immunofluorescence labeling assays for apoptosis, hypoxia, Western Blotting, Tunnel assay, measurement of 5-HT secretion by carbon fiber amperometry assay, quantitative methylation-specific PCR, morphologic changes, cell viability, apoptosis activity and the expression levels of phospho-Akt1, Akt1, HIF-1α, PI3K, p21, CAIX, 5-HT, phospho-mTOR, and mTOR in xenografts derived from typical H727 and atypical H720 BC cell lines.

28 Aug 2021

Mystery of roe deer embryonic diapause revealed

Everyone is familiar with the roe deer, either from crossword puzzles or from real-life encounters during a jog or a hike in the forest: majestic creatures with elegant big black eyes.

28 Aug 2021

Migraine-inducing peptides may protect against diabetes by influencing insulin production

People who get migraines are less likely to develop type 2 diabetes, while some people who develop diabetes become less prone to migraines.

26 Aug 2021

Cytokine APRIL plays a protective role against formation of atherosclerotic plaques

Heart attacks and strokes are the main causes of death and loss of productive years globally. These clinical complications are caused by atherosclerosis, which is a chronic disease that leads to the accumulation of LDL cholesterol and immune cells in the inner layer of arteries and thereby resulting in the build-up of atherosclerotic plaques.

26 Aug 2021

Apple, Bose and others pump up the volume on hearing aid options, filling void left by FDA

Spurred by decades of complaints about the high cost of hearing aids, Congress passed a law in 2017 to allow over-the-counter sales, with hopes it would boost competition and lower prices.

26 Aug 2021

Migraines may hold the key to new treatment for diabetes

The mechanistic association between migraines and type 2 diabetes reveals a new approach to treat diabetes.

26 Aug 2021

Study unravels widespread tumor suppression mechanism that halts cancer metastasis

According to a study by The Wistar Institute, the tumor suppressor Parkin, whose levels are reduced in different cancer types, causes acute metabolic and oxidative stress, suppresses mitochondrial trafficking, and blocks tumor cell movement, reducing primary and metastatic tumor growth.

26 Aug 2021

Glycyrrhizic acid as a drug candidate for COVID-19

A new study presents the benefits of licorice, an age-old herbal remedy, to treat COVID-19 at all stages.

24 Aug 2021

Headed away to school? Here’s what students with health issues need to know

College is a time of transition, but for those managing chronic medical conditions, it may also be the first time they will be wholly responsible for their own health: setting appointments, securing supplies and pharmaceuticals, and monitoring symptoms.

24 Aug 2021

Researchers identify a brief window of opportunity to prevent NF1-associated optic pathway glioma

Researchers at Children's National Hospital identified a vulnerability in a developmental signaling pathway that can be hijacked to drive pediatric low-grade glioma (pLGG) formation, according to a pre-clinical study published in Developmental Cell.

23 Aug 2021

Study investigates the effects of calycosin on breast cancer cell progression

Aging-US published "Calycosin inhibits breast cancer cell migration and invasion by suppressing EMT via BATF/TGF-β1" which reported that in this study, the authors investigated the effects of calycosin on breast cancer cell progression and their underlying mechanisms. Calycosin dose- and time-dependently inhibited proliferation, migration, and invasion by T47D and MCF-7 breast cancer cells by downregulating basic leucine zipper ATF-like transcription factor expression.

23 Aug 2021

Proliferation News and Research

Severe COVID-19 is associated with expansion of immature myeloid cells and inflammation

Novel assay helps identify factors that can convert normal cells into liver cancer cells

Newly discovered cell type makes survivors of sepsis more vulnerable to infections

Impact of neoadjuvant concurrent chemoradiation on exosomal markers expression in colorectal cancer

Defined & Controllable Extracellular Matrix for Cell Culture

New model shows how dysfunction in the air sacs initiates fibrotic cascade

New compounds offer a two-for-one punch to fight estrogen-sensitive breast cancer

DNMT2/TRDMT1 gene knockout may potentiate adverse effects related to drug-induced senescence

Researchers study the role of low-density granulocytes in COVID-19

Combination therapy disables PI3K/Akt/mTOR pathway and induces apoptosis in carcinoid syndrome

Mystery of roe deer embryonic diapause revealed

Migraine-inducing peptides may protect against diabetes by influencing insulin production

Cytokine APRIL plays a protective role against formation of atherosclerotic plaques

Apple, Bose and others pump up the volume on hearing aid options, filling void left by FDA

Migraines may hold the key to new treatment for diabetes

Study unravels widespread tumor suppression mechanism that halts cancer metastasis

Glycyrrhizic acid as a drug candidate for COVID-19

Headed away to school? Here’s what students with health issues need to know

Researchers identify a brief window of opportunity to prevent NF1-associated optic pathway glioma

Study investigates the effects of calycosin on breast cancer cell progression

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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