Bone Marrow News and Research

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Bone Marrow is the soft, sponge-like tissue in the center of most bones. It produces white blood cells, red blood cells, and platelets.

Aza-ven shows superior outcomes compared to induction chemotherapy in AML patients

In a new trial, patients newly diagnosed with acute myeloid leukemia (AML) fared significantly better with a combined regimen of azacitidine and venetoclax compared with conventional induction chemotherapy.

7 Dec 2025

Fixed-duration therapy works as effectively as continuous treatment for chronic lymphocytic leukemia

According to a new trial, patients with chronic lymphocytic leukemia (CLL) show comparable outcomes whether they receive a single-agent treatment indefinitely or a combination treatment for a fixed period of time.

7 Dec 2025

Chemotherapy-based conditioning matches outcomes of total body irradiation for MRD-negative B-ALL

In a new trial, patients with B-acute lymphoblastic leukemia (B-ALL) who had no evidence of remaining cancer cells after prior treatment, experienced comparable outcomes whether they received chemotherapy-based conditioning or total body irradiation (TBI), the standard conditioning regimen used before hematopoietic cell transplantation.

7 Dec 2025

Black patients with AML experience earlier onset and poorer outcomes

Compared with white patients, Black patients with acute myeloid leukemia (AML) were on average more than five years younger at diagnosis, more than 30% more likely to die of their disease, and more than 20% more likely to die of any cause, according to an analysis of data conducted over a 34-year period and supported by the National Cancer Institute (NCI) is a component of the U.S. National Institutes of Health.

7 Dec 2025

Challenges and opportunities in delivering gene therapies for sickle cell disease and beta thalassemia

The first study assessing the real-world commercial roll-out of gene therapies for sickle cell disease and beta thalassemia offers lessons learned to inform best practices as manufacturers and medical centers prepare to meet growing demand for gene therapies in the coming years.

7 Dec 2025

New evidence shows hematopoietic cell transplantation offers durable relief for sickle cell disease

Patients who underwent hematopoietic cell transplantation for sickle cell disease saw high rates of survival without disease symptoms and low rates of severe side effects or complications years after their procedure, according to a new study.

7 Dec 2025

Exa-cel shows complete success in early pediatric trials for sickle cell disease and beta-thalassemia

Preliminary results from two trials of the gene therapy exagamglogene autotemcel (exa-cel) suggest the therapy offers an effective cure for beta-thalassemia and sickle cell disease in children younger than 12.

6 Dec 2025

New rapid test distinguishes real HIV infections from vaccine-related false positives

Since the human immunodeficiency virus (HIV) was identified in 1983, roughly 91.4 million people around the world have contracted the virus and an additional 44.1 million have died from related causes.

3 Dec 2025

A new generation of AML treatments brings hope for better survival

A new generation of targeted treatments and gentler chemotherapy options for older adults with a new diagnosis of acute myeloid leukemia (AML) is driving better survival and cure rates.

1 Dec 2025

Fanconi anemia patients show striking metabolic differences

Experts at Cincinnati Children's have uncovered striking metabolic differences in people with Fanconi anemia (FA), a rare genetic disorder that causes bone marrow failure and dramatically increases cancer risk.

29 Nov 2025

Breakthrough immunotherapy approved for treatment of adults with aggressive blood cancer

Adult patients with an aggressive form of leukemia will be able to receive a breakthrough immunotherapy, which was invented by UCL researchers, on the NHS within weeks following approval for use by the National Institute for Health and Care Excellence (NICE).

27 Nov 2025

Tattoo ink alters immune cells and weakens some vaccine responses

New research shows tattoo pigments migrate to lymph nodes, causing inflammation and altering immune responses to vaccines, with potential health risks.

27 Nov 2025

Regenerative medicine offers a pathway toward curing type 1 diabetes

Type 1 diabetes (T1D) is an autoimmune disorder characterized by the specific destruction of insulin-producing pancreatic β-cells.

26 Nov 2025

Study overturns assumptions about PTPN22 risk gene’s role in interferon production

A new paper from the University of Kansas overturns the idea that a "risk gene" carried by millions of people worldwide influences production of Type 1 interferon, a workhorse of the immune system.

25 Nov 2025

Scientists reverse aging in blood stem cells by restoring lysosome function

Researchers at the Icahn School of Medicine at Mount Sinai have discovered how to reverse aging in blood-forming stem cells in mice by correcting defects in the stem cell's lysosomes.

24 Nov 2025

Longest survival in the world reported to date for multiple myeloma patients

Berenson Cancer Center published survival data analyzed by the Institute for Myeloma & Bone Cancer Research of 175 consecutive and unselected patients with multiple myeloma in the journal Haematologica.

19 Nov 2025

New transplant approach resets the immune system to stop Type 1 diabetes

A combination blood stem cell and pancreatic islet cell transplant from an immunologically mismatched donor completely prevented or cured Type 1 diabetes in mice in a study by Stanford Medicine researchers.

18 Nov 2025

New human-cell bone marrow model offers alternative to animal experiments

Our body's "blood factory" consists of specialized tissue made up of bone cells, blood vessels, nerves and other cell types.

18 Nov 2025

Researchers identify key differences between two subtypes of chronic lymphocytic leukemia

Researchers at the University of Eastern Finland and their international collaborators have identified key developmental and molecular differences between the two main subtypes of chronic lymphocytic leukemia, CLL.

18 Nov 2025

Fondazione Telethon achieves milestone with Waskyra approval for Wiskott-Aldrich Syndrome

Fondazione Telethon announces the positive opinion issued by the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) recommending marketing authorization in the European Union for Waskyra, an ex vivo gene therapy for Wiskott-Aldrich Syndrome (WAS), a rare and life-threatening primary immunodeficiency.

14 Nov 2025

Bone Marrow News and Research

Further Reading

Aza-ven shows superior outcomes compared to induction chemotherapy in AML patients

Fixed-duration therapy works as effectively as continuous treatment for chronic lymphocytic leukemia

Chemotherapy-based conditioning matches outcomes of total body irradiation for MRD-negative B-ALL

Black patients with AML experience earlier onset and poorer outcomes

Challenges and opportunities in delivering gene therapies for sickle cell disease and beta thalassemia

New evidence shows hematopoietic cell transplantation offers durable relief for sickle cell disease

Exa-cel shows complete success in early pediatric trials for sickle cell disease and beta-thalassemia

New rapid test distinguishes real HIV infections from vaccine-related false positives

A new generation of AML treatments brings hope for better survival

Fanconi anemia patients show striking metabolic differences

Breakthrough immunotherapy approved for treatment of adults with aggressive blood cancer

Tattoo ink alters immune cells and weakens some vaccine responses

Regenerative medicine offers a pathway toward curing type 1 diabetes

Study overturns assumptions about PTPN22 risk gene’s role in interferon production

Scientists reverse aging in blood stem cells by restoring lysosome function

Longest survival in the world reported to date for multiple myeloma patients

New transplant approach resets the immune system to stop Type 1 diabetes

New human-cell bone marrow model offers alternative to animal experiments

Researchers identify key differences between two subtypes of chronic lymphocytic leukemia

Fondazione Telethon achieves milestone with Waskyra approval for Wiskott-Aldrich Syndrome

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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