Chromatin News and Research

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Epigenetic dysregulation drives hepatocellular carcinoma development

Hepatocellular carcinoma (HCC) is the most common primary liver cancer and a leading cause of cancer-related deaths worldwide.

19 Jun 2025

CHAF1B drives lung squamous cell carcinoma progression by repressing SETD7

CHAF1B, a histone chaperone component of the chromatin assembly factor-1 complex, is overexpressed in multiple cancers and linked to tumor progression, but its role in lung squamous-cell carcinoma (LUSC) remained unclear.

11 Jun 2025

SIRT6 identified as a critical safeguard of spinal disc health

Low back pain is the most prevalent musculoskeletal condition worldwide and is closely tied to the progressive degeneration of intervertebral discs.

5 Jun 2025

Researchers map DNA regions that activate liver regeneration

The mammalian liver has an extraordinary regenerative capacity, capable of fully restoring its mass and function after injury or partial resection.

4 Jun 2025

New discovery reveals how cohesin complex alters gene expression

Cohesin is a protein that forms a ring-shaped complex which wraps and alters the DNA molecule shape. It moves through the DNA and creates specific loops in the genetic material which determine the architecture of the genome and gene expression.

29 May 2025

Cutting back on sugary drinks may protect men’s fertility, review finds

Regular consumption of sugar-sweetened beverages is associated with lower sperm count, motility, and increased DNA damage, potentially impairing male reproductive health. This narrative review highlights dose-response effects, mechanisms, and research gaps, calling for further studies on diverse populations.

22 May 2025

Scientists identify key molecular process driving deadly childhood brain cancer

An international group of scientists has identified a key molecular process that drives a deadly form of childhood brain cancer, potentially offering a much-needed, new therapeutic target.

21 May 2025

Study deciphers the role of histone deacetylases in lymphoma development

Lymphomas belong to the group of malignant diseases of the immune system and mainly affect the organs of the lymphatic system.

15 May 2025

RANBP2 identified as key regulator in the progression of multiple solid tumors

The nuclear pore complex protein RANBP2 has emerged as a critical factor in the development and progression of various solid malignancies.

12 May 2025

Why your baby’s first steps may be written in their DNA

Researchers identified 11 genetic loci linked to the age at which infants start walking, revealing that this milestone is influenced by thousands of common genetic variants. These genetic factors also correlate with brain development, cognitive traits, and neurodevelopmental conditions like ADHD.

8 May 2025

COVID-19 lowers sperm count and motility, new study confirms

SARS-CoV-2 infection is linked to significant declines in sperm quality, including reduced sperm count, motility, and increased DNA fragmentation, as shown in both cross-sectional and longitudinal observations.

24 Apr 2025

Exploring citrullination as a key regulator of gene expression and disease

Citrullination, a transformative protein post-translational modification, is gaining recognition for its wide-ranging impact on cellular function and human disease.

20 Apr 2025

Exploring the impact of R-loops on genome integrity and disease

This new review article highlights the pivotal and paradoxical role of R-loops in maintaining genomic stability while simultaneously posing risks to it.

19 Apr 2025

New discoveries explain how DNA repair signals are controlled

Researchers from the University of Birmingham have uncovered answers that provide the detail to explain two specific DNA repair processes that have long been in question.

16 Apr 2025

New assay detects epigenetic changes caused by carcinogenic chemicals

Chemicals used as food preservatives, flavoring agents, dyes, pesticides, cosmetics, cleaners, and other industrial materials are being increasingly recognized as a health hazard.

10 Apr 2025

Can psychedelics break compulsive eating habits in obesity?

A review by Oxford researchers explores how psychedelics like psilocybin and LSD may help disrupt compulsive eating behaviors in subsets of obese individuals. The paper outlines proposed neurobiological, epigenetic, and gut-brain mechanisms while emphasizing the need for human trials.

10 Apr 2025