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Researchers boost natural defenses to fight cataracts and delay the need for surgery

Researchers have reviewed strategies to increase glutathione levels in the eye lens, focusing on endogenous molecular mechanisms to prevent cataracts by countering oxidative stress.

3 Oct 2024

Study identifies brain circuit linking psychedelics to reduced anxiety

Psychedelics have been used in indigenous cultures for centuries, with empirical evidence of their mood and perception altering effects.

3 Oct 2024

Regulating iron overload: Liraglutide's potential benefits

Researchers assess the role of liraglutide in regulating iron metabolism in a mouse model of hereditary hemochromatosis.

30 Sep 2024

Liver receptor mutations linked to liver dysfunction, cholesterol accumulation, and hepatitis

Damaging LXRα variants are linked to liver cholesterol buildup and hepatitis, emphasizing the receptor's importance in cholesterol sensing and liver function.

27 Sep 2024

New discovery offers hope for overcoming CAR-T cell therapy resistance

Mayo Clinic researchers mined the molecular foundations of cancer and uncovered a new reason chimeric antigen receptor (CAR-T cell therapy) fails in some patients.

12 Sep 2024

Researchers uncover why typically normal protein drives prostate cancer

NSD-2 is crucial for AR activity in prostate cancer, promoting tumor growth and offering a potential therapeutic target for advanced prostate cancer treatment.

12 Sep 2024

Early cholesterol spikes fuel atherosclerosis by altering macrophages

Early intermittent hyperlipidemia significantly accelerates atherosclerosis by disrupting macrophage function, highlighting the need for early cholesterol management.

6 Sep 2024

Discovery of borderzone inflammation offers new avenues for heart failure prevention

Ischemic heart disease is the most common cause of death in the world. It begins with a "heart attack", also known as a myocardial infarction (MI), which causes part of the heart to die due to inadequate coronary blood flow.

29 Aug 2024

Study reveals key role of A20 protein in controlling inflammation in liver disease

Many individuals worldwide suffer from chronic liver disease (CLD), which poses significant concerns for its tendency to lead to hepatocellular carcinoma or liver failure. CLD is characterized by inflammation and fibrosis.

29 Aug 2024

ASTN2 gene knockout in mice reveals key autism-related behaviors

More than 70 genes have been linked to autism spectrum disorder (ASD), a developmental condition in which differences in the brain lead to a host of altered behaviors, including issues with language, social communication, hyperactivity, and repetitive movements.

16 Aug 2024

AlphaFold accelerates discovery of potential antipsychotic drugs by outperforming traditional methods

Researchers used AlphaFold and homology modeling to identify potent TAAR1 agonists, showing AlphaFold's superior performance in drug discovery for neuropsychiatric conditions.

13 Aug 2024

Prenatal BPA exposure tied to autism risk in boys

Study reveals that prenatal exposure to BPA disrupts aromatase activity in male brains, potentially leading to autism-like symptoms. Treatment with 10-HDA shows promise in reversing these effects.

11 Aug 2024

ATP regulation in ClC-3 exchangers linked to neurodegenerative diseases, study reveals

Researchers structurally analyzed adenine nucleotide control and neurodegenerative diseases in ClC-3 exchangers.

11 Aug 2024

New $11.3 million grant to explore endothelial cell dysfunction in cardiovascular disease

With a new $11.3 million Program Project grant from the National Institutes of Health, experts from the Vascular Biology Center at the Medical College of Georgia at Augusta University are working to better understand the underlying mechanisms of cardiovascular disease.

8 Aug 2024

Study explores interplay between bone, adrenal glands, and aging

Figuring out how the tissues in our bones, adrenal glands, muscle and fat "talk" to each other could help scientists better understand what happens to our skeletons with age, when our bones tend to lose mass and become weaker, leaving us at risk for falls and fractures.

1 Aug 2024

Knockout News and Research

Researchers boost natural defenses to fight cataracts and delay the need for surgery

Study identifies brain circuit linking psychedelics to reduced anxiety

Regulating iron overload: Liraglutide's potential benefits

Liver receptor mutations linked to liver dysfunction, cholesterol accumulation, and hepatitis

New discovery offers hope for overcoming CAR-T cell therapy resistance

Researchers uncover why typically normal protein drives prostate cancer

Early cholesterol spikes fuel atherosclerosis by altering macrophages

Discovery of borderzone inflammation offers new avenues for heart failure prevention

Study reveals key role of A20 protein in controlling inflammation in liver disease

ASTN2 gene knockout in mice reveals key autism-related behaviors

AlphaFold accelerates discovery of potential antipsychotic drugs by outperforming traditional methods

Prenatal BPA exposure tied to autism risk in boys

ATP regulation in ClC-3 exchangers linked to neurodegenerative diseases, study reveals

New $11.3 million grant to explore endothelial cell dysfunction in cardiovascular disease

Study explores interplay between bone, adrenal glands, and aging

Asimov introduces its AI-driven 4th generation CHO Edge System with increased titer guarantee

Genetic loss of miR-205 boosts mammary gland development in mice, reveals new insights into breast cancer suppression

Garlic as a potent weapon against atherosclerosis

Loss of Gα13 in B-cells linked to increased lymphoma risk due to dietary glutamine

Oligodendrocytes identified as key amyloid β producers in Alzheimer's disease

Advancing Intracellular Delivery with LumiPore®

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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