Organoids News and Research

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Organoids are three-dimensional cell cultures from embryonic stem cells or induced pluripotent stem cells that model important features of whole organs.

Embryonic stem cells used to recreate thyroid cancer histotypes

A recent Nature Communications study revealed the recapitulating capacity of human embryonic stem cells (hESCs) to elucidate the cellular hierarchy of the thyroid gland. Furthermore, these cells possessed the capacity to reproduce the oncogenic process using the CRISPR-based genetic editing method.

14 Mar 2023

ACE2: its diverse functions, relationship with SARS-CoV-2, and the implications for COVID-19 disease sequelae

Researchers assessed the role of ACE2 in the COVID-19 pandemic.

9 Mar 2023

Using tissue-embedded nanoelectronic devices to monitor the functional maturation of cardiomyocytes

Research in animal models has demonstrated that stem-cell derived heart tissues have promising potential for therapeutic applications to treat cardiac disease. But before such therapies are viable and safe for use in humans, scientists must first precisely understand on the cellular and molecular levels which factors are necessary for implanted stem-cell derived heart cells to properly grow and integrate in three dimensions within surrounding tissue.

8 Mar 2023

Gut bacteria influence the liver's regenerative ability

When parts of the liver are removed, the body can replace the missing tissue. A team of researchers at the Technical University of Munich has now discovered that the success of this process depends to a large extent on gut bacteria.

1 Mar 2023

Scientists working to create revolutionary biocomputers powered by brain organoids

Artificial intelligence (AI) has long been inspired by the human brain. This approach proved highly successful: AI boasts impressive achievements – from diagnosing medical conditions to composing poetry.

28 Feb 2023

Organoid models for research on Chinese herbal medicine

Announcing a new publication for Acta Materia Medica journal. Organoids are three-dimensional cell accusations generated from pluripotent stem cells or adult stem cells in vitro.

24 Feb 2023

Novel fatty liver organoid models could aid in drug discovery and testing

Researchers from the Organoid group (former Clevers group, Hubrecht Institute) together with researchers from the Princess Máxima Center for pediatric oncology established novel human organoid models of fatty liver disease.

23 Feb 2023

Researchers report the circulation of a novel MERS-like coronavirus in Malayan pangolins

Researchers reported the circulation of a novel MERS-like coronavirus among Malayan pangolins, Manis javanica HKU4-associated CoV (MjHKU4r-CoV).

21 Feb 2023

First fully human ovarian organoids provide insights about female reproductive health and disease

Despite the fact that we all start out as an egg cell in one of our mother's ovaries, these human reproductive organs are surprisingly under-studied.

21 Feb 2023

Scientists identify miRNAs associated with type 2 diabetes in humans

MicroRNA (miRNA) molecules in pancreatic islets have been thought to play important roles in type 2 diabetes, but until now scientists have not confidently identified which miRNAs are associated with the disease in humans.

10 Feb 2023

Researchers identify 27 genetic risk variants related to ADHD

Why do some people get ADHD, while others do not? And how early in life or in the womb is the seed of ADHD sown?

9 Feb 2023

Deletion of a tumor suppressor gene promotes luminal breast cancer development and resistance to endocrine therapy

A research team from LKS Faculty of Medicine, the University of Hong Kong (HKUMed) discovered that somatic deletion of a tumor suppressor gene AKTIP promotes luminal breast cancer development and resistance to endocrine therapy.

3 Feb 2023

Pulmonary surfactant-mediated inflammatory response against SARS-CoV-2

Researchers discuss the role of a surfactant-mediated inflammatory response employed by human lungs against SARS-CoV-2.

3 Feb 2023

CuSTOM; Creating a healthier society by accelerating the translation of organoid technology

In this interview, we speak to Magdalena Kasendra at the CuSTOM Accelerator, about the organoid technology and how it has the power the revolutionize healthcare.

From Society for Laboratory Automation and Screening (SLAS) 1 Feb 2023

Cochlear avatars provide a platform for deciphering the mechanisms of sensorineural hearing loss

Disabling hearing loss affects one in every ten people and up to 25% of people over 60, according to the World Health Organization, and can have both genetic and environmental causes such as infections and noise exposure.

1 Feb 2023

Study suggests cortical hemorrhage in fetal brain may be associated with COVID-19

Researchers evaluated the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections on fetal brain health.

25 Jan 2023

Novel method makes genetic analyses possible for all regions of the intestine

With its length and multitude of folds and protrusions, the intestine represents the largest contact surface between our body and the food taken up from the outside.

23 Jan 2023

Senolytics could be a beneficial therapeutic for COVID neuropathology

Researchers assess the effectiveness of multiple senolytic interventions in removing senescent cells in aged human brain organoids.

22 Jan 2023

2023 EVIDENT Organoid Conference to share the latest organoid innovations

Building on the momentum from last year’s conference, the 2023 Evident Organoid Conference will highlight organoid innovations that are poised to accelerate progress in drug research and discovery.

From Evident Corporation - Life Sciences 18 Jan 2023

Do hPSC-derived retinal neurons possess intrinsic potential to form new synaptic connections after extraction from organoids?

Researchers successfully demonstrated that lab-grown retinal organoids made new synaptic connections, theoretically establishing their potential to treat blindness due to retinal degenerative diseases.

13 Jan 2023