Preclinical News and Research

RSS

Study links dietary fructose to aggressive spread of ovarian cancer

A new study from The Wistar Institute has uncovered an unexpected link between fructose - a common dietary sugar - and the spread of an aggressive form of ovarian cancer.

30 Jul 2026

Lanthanide carriers advance next generation biomedical imaging and theranostics

Lanthanide carriers could help define the next generation of biomedical imaging and fast-track the emerging field of theranostics-approaches that link diagnostic imaging with treatment selection, delivery, or monitoring.

30 Jul 2026

Immature NK cells in donor cord blood can undermine CAR NK cell therapy activity

The composition of donor cord blood may play a critical role in the success of chimeric antigen receptor (CAR) natural killer (NK) cell therapies.

29 Jul 2026

FDA grants fast track designation to Insilico's AI-designed mesothelioma drug candidate

Insilico Medicine ("Insilico"; HKEX: 3696), a clinical-stage generative artificial intelligence (AI)-driven drug discovery company, today announced that ISM6331, a novel, potential best-in-class pan-TEAD inhibitor driven by Insilico's proprietary AI, has received Fast Track Designation (FTD) from the U.S.

29 Jul 2026

Overactive brain immune response linked to rare, severe genetic epilepsy

An overactive immune response in the brain may play a role in Dravet Syndrome, a rare and severe genetic epilepsy that typically begins in infancy, according to Weill Cornell Medicine researchers.

29 Jul 2026

Brain cancer Achilles heel revealed in the hours after surgery

Scientists in Britain and Spain have discovered critical windows after glioblastoma surgery when the brain’s defenses falter, creating a rare chance to deliver powerful treatments exactly where needed.

29 Jul 2026

Blocking the Axl receptor may offer a new way to promote bone formation

Osteoporosis is one of the most common age-related bone diseases, affecting millions of people worldwide and increasing the risk of fractures, disability, and reduced quality of life.

28 Jul 2026

Research reveals how a hidden immune cell army defends human lung tissue

New research led by scientists at La Jolla Institute for Immunology (LJI) and University of Liverpool (UOL) provides the first comprehensive look at how a hidden immune cell army defends the vast, vulnerable tissue of the human lungs.

28 Jul 2026

Rare BTK mutation drives resistance to targeted therapies for blood cancer

Scientists at Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine, and collaborators have uncovered a rare genetic mutation that enables some blood cancers to evade both approved Bruton tyrosine kinase (BTK) inhibitors and newer BTK degraders, a finding that could help shape the next generation of therapies for patients with chronic lymphocytic leukemia (CLL) and related malignancies.

27 Jul 2026

A common dietary nutrient feeds a gut pathway linked to atrial fibrillation

Researchers linked higher plasma TMAO to prevalent atrial fibrillation in 5,090 people and found that TMAO or choline supplementation accelerated AF onset, progression, atrial remodeling, and electrical dysfunction in mice. Inhibiting gut microbial TMA production lowered circulating TMAO and delayed AF in mice, identifying a potential therapeutic pathway that now requires human testing.

27 Jul 2026

New injectable hydrogel accelerates healing of deep wounds

Any minor cut or scrape sets the body's natural healing process in motion. However, deep wounds are far more vulnerable to bacterial infection and the accumulation of harmful molecules called reactive oxygen species (ROS) that damage cells and disrupt normal repair mechanisms.

27 Jul 2026

New cancer vaccine harnesses COVID-19 immune memory to fight tumors

In a discovery that could redefine the future of cancer immunotherapy, scientists from Celloram Inc., University Hospitals and Case Western Reserve University have developed a novel cancer vaccine platform that transforms the impact of the largest immunological event in modern history – a synchronized mass immune memory generated through SARS-CoV-2 infection and vaccination – into a powerful ally against cancer.

27 Jul 2026

Amyloid beta misfolding predicts Alzheimer's years before symptoms appear

Widely used Alzheimer’s biomarker P-tau 217 reliably detects the disease only at the clinical stage. The protein misfolding of amyloid beta indicates an increased risk years earlier.

27 Jul 2026

Engineered probiotic bacteria boost immune attack against pancreatic cancer

Cancer immunotherapies have transformed treatment for many cancers, but pancreatic cancer remains especially difficult to treat. One major reason is that pancreatic tumors often create a "cold" tumor microenvironment, where the tumor prevents immune cells from mounting a strong attack.

24 Jul 2026

Longer activity bouts link to lower future dementia and mental health risks

A UK Biobank analysis of 66,483 adults found that longer daily moderate-to-vigorous activity bouts and less fragmented activity were associated with lower subsequent risks of inpatient diagnoses of dementia, depression, and anxiety, independent of total activity time. In neuroimaging data from 13,108 participants, these activity patterns were also associated with more favorable brain measures, although the observational analyses cannot establish cause and effect.

23 Jul 2026

Evidence shows artificial sweeteners cannot be judged as a single group

This narrative review found that non-nutritive artificial sweeteners have compound-specific and context-dependent associations with gut microbiota, metabolism, and health-related outcomes. Evidence does not support treating all sweeteners as uniformly harmful or safe, with human findings often limited or inconsistent.

23 Jul 2026

Mass-producible immune cells fight solid human tumors in mice

Off-the-shelf and mass-producible immune cells fight solid human tumors engrafted into mice. The Kobe University development is a significant contribution towards faster and cheaper cancer immunotherapy.

23 Jul 2026

New mechanism behind chemotherapy resistance in ovarian cancer discovered

Scientists at The Wistar Institute have identified a new mechanism behind the chemotherapy resistance that makes ovarian cancer so lethal.

23 Jul 2026

AI-powered analytics and experimental validation: Transforming target identification in drug discovery

Discover how AI-powered analytics and experimental validation combine to improve target identification and accelerate drug discovery success.

From Axxam S.p.A 23 Jul 2026

Spermidine boosts key cellular processes linked to aging in early research

This review finds that spermidine supports autophagy, mitochondrial function, and healthspan in experimental models, while observational studies link higher dietary intake to lower mortality. However, human trials have produced limited and mixed results, leaving its clinical role in healthy aging unresolved.

23 Jul 2026