Hippocampus News and Research

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The hippocampus is a part of the forebrain, located in the medial temporal lobe. It belongs to the limbic system and plays major roles in short term memory and spatial navigation. Humans and other mammals have two hippocampi, one in each side of the brain.

Findings suggest possible clinical uses of ecstasy in treating anxiety and PTSD

Brain imaging experiments have revealed for the first time how ecstasy produces feelings of euphoria in users.

17 Jan 2014

Higher vitamin D levels linked with better cognition and less depression in PD patients

A new study exploring vitamin D levels in patients with Parkinson's disease (PD) opens up the possibility of a new avenue of early intervention that may delay or prevent the onset of cognitive impairment and depression. The findings are published in the Journal of Parkinson's Disease.

16 Jan 2014

Cedars-Sinai researcher to receive 2014 Troland Research Award

Ueli Rutishauser, PhD, assistant professor of neurosurgery and director of human neurophysiology research in the Department of Neurosurgery and the Department of Neurology at Cedars-Sinai, will receive a 2014 Troland Research Award at the National Academy of Sciences annual meeting April 27.

16 Jan 2014

HDAC2 inhibitor could improve post-traumatic stress disorder treatment: Study

Nearly 8 million Americans suffer from posttraumatic stress disorder, a condition marked by severe anxiety stemming from a traumatic event such as a battle or violent attack.

16 Jan 2014

Cognigram can detect early signs of MCI and Alzheimer’s disease

For patients over the age of 50, a routine physical exam at the doctor’s office typically covers a wide spectrum of medical biomarkers with one glaring exception, cognitive health. Unless there have been unusual mental changes or challenges in their daily life, tests of a patient’s attention, memory or brain processing speed is usually not part of a check-up.

15 Jan 2014

Mannotriose regulates learning and memory signal transduction in hippocampus

The main component of the Chinese herb Rehmannia, mannotriose, can improve learning and memory. Dr. Lina Zhang and colleagues from Shanghai University of Traditional Chinese Medicine in China used 1 - 10 mol/L mannotriose to treat primary hippocampal neurons insulted with 1 - 10 mol/L corticosterone.

7 Jan 2014

Researchers find inhibition of basic cellular process that contributes to schizophrenia

Surprisingly little is known about schizophrenia. It was only recognized as a medical condition in the past few decades, and its exact causes remain unclear. Since there is no objective test for schizophrenia, its diagnosis is based on an assortment of reported symptoms.

30 Dec 2013

CUMC researchers clarify three fundamental issues about Alzheimer's disease

Using high-resolution functional MRI imaging in patients with Alzheimer's disease and in mouse models of the disease, Columbia University Medical Center researchers have clarified three fundamental issues about Alzheimer's: where it starts, why it starts there, and how it spreads. In addition to advancing understanding of Alzheimer's, the findings could improve early detection of the disease, when drugs may be most effective.

22 Dec 2013

Studies suggest that stress-related disorders may be associated with hippocampal volume loss

Depression has been associated with reduced volume of the hippocampus in magnetic resonance imaging studies in humans. A new study just published in Biological Psychiatry now clarifies the cellular basis of these volumetric changes, which have been unclear until now.

18 Dec 2013

New study aims to better understand brain aging and AD in adults with Down syndrome

To many, Down syndrome is a childhood condition. But improved health care means that individuals with DS now routinely reach age 50 or 60 years of age, sometimes beyond. However, if they live long enough, people with Down syndrome are almost certain to develop Alzheimer's disease.

17 Dec 2013

Study: Brain blood vessel cells may be therapeutic targets for Alzheimer's disease

A study in mice shows how a breakdown of the brain's blood vessels may amplify or cause problems associated with Alzheimer's disease. The results published in Nature Communications suggest that blood vessel cells called pericytes may provide novel targets for treatments and diagnoses.

14 Dec 2013

Penn researchers identify protein that could clear Alzheimer's plaques

The body is structured to ensure that any invading organisms have a tough time reaching the brain, an organ obviously critical to survival. Known as the blood-brain barrier, cells that line the brain and spinal cord are tightly packed, making it difficult for anything besides very small molecules to cross from the bloodstream into the central nervous system. While beneficial, this blockade also stands in the way of delivering drugs intended to treat neurological disorders, such as Alzheimer's.

9 Dec 2013

Prolonged febrile seizures can affect pediatric patients

A long-standing hypothesis holds that prolonged febrile (fever induced) seizures, the most common form of childhood convulsive status epilepticus, cause mesial temporal sclerosis. CSE is a single seizure, or two or more seizures between which consciousness is not regained, lasting for more than 30 minutes.

9 Dec 2013

MRI-guided SLA surgery proves safe and shows adequate efficacy for seizure control

MRI-Guided Stereotactic Laser Ablation of the hippocampus to control seizures in people with temporal lobe epilepsy may result in seizure control that approaches that from anterior temporal lobectory or selective amygdalohippocampectomy and better cognitive outcomes than any of the standard open resections, according to a study presented at the American Epilepsy Society's 67th Annual Meeting in Washington DC.

9 Dec 2013

Research roundup: 'Substantial' Medicare savings from avoiding ERs; new ways for primary care; trends in kids' fast food consumption

Some Medicare beneficiaries who place 911 calls to request an ambulance might safely be cared for in settings other than the emergency department at lower cost. Using 2005–09 Medicare claims data and a validated algorithm, we estimated that 12.9–16.2 percent of Medicare-covered 911 emergency medical services transports involved conditions that were probably nonemergent or primary care treatable.

9 Dec 2013

Underlying loss of awareness during partial seizures is same as deep sleep

Epilepsy patients with complex partial seizures have impaired consciousness during seizure episodes and typically have no memory of the event. However, the mechanisms of seizure unconsciousness are unclear.

9 Dec 2013

Scientists receive 2013 Horwitz Prize for discoveries on how brain calculates location, navigation

Edvard and May-Britt Moser of the Norwegian University of Science and Technology (NTNU), and John O'Keefe, from University College London have been awarded the 2013 Louisa Gross Horwitz Prize for discoveries that have illuminated how the brain calculates location and navigation.

9 Dec 2013

Downregulation of caveolin-1 contributes to synaptic plasticity deficit in hippocampus of aged rats

Caveolin-1 may be a new target for interfering with age-dependent decline in synaptic plasticity. To explore the relationship between synaptic plasticity in the aging process and changes in learning and memory, Dr. Yang Liu and coworkers from the First Affiliated Hospital, Dalian Medical University, China examined synaptophysin expression in the hippocampus, cortex and cerebellum of rats at different ages, and analyzed the association between synaptophysin expression and cognition and behaviors.

9 Dec 2013

Scientists receive 2013 Louisa Gross Horwitz Prize for advancements in field of neuroscience

For discoveries about how the brain calculates and remembers where it is—which could be part of the foundation of memory—Columbia University will award the 2013 Louisa Gross Horwitz Prize to Edvard I. Moser, PhD, and May-Britt Moser, PhD, of the Norwegian University of Science and Technology in Norway, and John Michael O'Keefe, PhD, of University College London in the UK.

6 Dec 2013

Biologists discover how nerve cells recycle tiny vesicles

University of Utah and German biologists discovered how nerve cells recycle tiny bubbles or "vesicles" that send chemical nerve signals from one cell to the next. The process is much faster and different than two previously proposed mechanisms for recycling the bubbles.

5 Dec 2013

Hippocampus News and Research

Further Reading

Findings suggest possible clinical uses of ecstasy in treating anxiety and PTSD

Higher vitamin D levels linked with better cognition and less depression in PD patients

Cedars-Sinai researcher to receive 2014 Troland Research Award

HDAC2 inhibitor could improve post-traumatic stress disorder treatment: Study

Cognigram can detect early signs of MCI and Alzheimer’s disease

Mannotriose regulates learning and memory signal transduction in hippocampus

Researchers find inhibition of basic cellular process that contributes to schizophrenia

CUMC researchers clarify three fundamental issues about Alzheimer's disease

Studies suggest that stress-related disorders may be associated with hippocampal volume loss

New study aims to better understand brain aging and AD in adults with Down syndrome

Study: Brain blood vessel cells may be therapeutic targets for Alzheimer's disease

Penn researchers identify protein that could clear Alzheimer's plaques

Prolonged febrile seizures can affect pediatric patients

MRI-guided SLA surgery proves safe and shows adequate efficacy for seizure control

Research roundup: 'Substantial' Medicare savings from avoiding ERs; new ways for primary care; trends in kids' fast food consumption

Underlying loss of awareness during partial seizures is same as deep sleep

Scientists receive 2013 Horwitz Prize for discoveries on how brain calculates location, navigation

Downregulation of caveolin-1 contributes to synaptic plasticity deficit in hippocampus of aged rats

Scientists receive 2013 Louisa Gross Horwitz Prize for advancements in field of neuroscience

Biologists discover how nerve cells recycle tiny vesicles

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