Pathology News and Research

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Pathology is the study and diagnosis of disease through examination of organs, tissues, bodily fluids, and whole bodies (autopsies). The term also encompasses the related scientific study of disease processes, called General pathology. Medical pathology is divided in two main branches, Anatomical pathology and Clinical pathology. Veterinary pathology is concerned with animal disease whereas Phytopathology is the study of plant diseases.

St. Jude Children's researchers better define hyperdiploidy in childhood B-ALL

Hyperdiploidy is a genetic condition observed in cancer cells, where the cells contain more chromosomes than usual.

20 Sep 2023

Early treatment with convalescent plasma may reduce risk of long COVID

Findings from a nationwide, multicenter study led by Johns Hopkins Medicine and the Johns Hopkins Bloomberg School of Public Health suggest that patients with COVID-19 have less chance of developing post-COVID conditions - commonly known as long COVID - if they receive early treatment with plasma from convalescent (recovered) COVID patients that contain antibodies against SARS-CoV-2, the virus that causes COVID-19.

20 Sep 2023

AI-based tool can assess pathology slides to identify valuable features of clear cell renal cell carcinoma

A team of Dana-Farber researchers has identified a potential new way to assess clinically valuable features of clear cell renal cell carcinoma (ccRCC), a form of kidney cancer, using image processing with deep learning.

20 Sep 2023

Researchers identify key mechanisms to address future treatments for hereditary blindness

There are still many enigmas about the mechanism of action of the CERKL gene, which causes retinitis pigmentosa and other hereditary vision diseases.

18 Sep 2023

Single-cell screening of cerebral organoids to identify developmental defects in autism

Researchers develop CRISPR-human organoids-single-cell RNA sequencing system to identify developmental brain defects in autism.

18 Sep 2023

BU researchers receive NIH grant to identify genetic factors for Alzheimer's disease

The National Institutes of Health/National Institute on Aging recently awarded a $13.7 million grant to a project led by Boston University Chobanian & Avedisian School of Medicine principal investigators Lindsay Farrer, PhD, chief of biomedical genetics and distinguished professor of genetics, and Richard Sherva, PhD, assistant professor of medicine in biomedical genetics, for research using whole genome sequencing and other approaches to identify genetic factors for Alzheimer disease (AD) in Jews currently living in Israel who trace their ancestors to southern Spain and locations in the Middle East and North Africa (MENA) and Arab citizens of Israel.

15 Sep 2023

How does the APOE4 gene play both hero and villain in your health risks?

The study reveals that APOE4, a genetic risk factor for Alzheimer's Disease and cardiovascular diseases, has complex effects on mortality risk. While APOE4 carriers with higher AD neuropathology have increased mortality risk, those with low neuropathology had a reduced risk of certain cancers, warranting further research into this genetic factor's diverse impact on health outcomes.

14 Sep 2023

Innovative technique provides unparalleled insight into autism pathology

Does the human brain have an Achilles heel that ultimately leads to Autism? With a revolutionizing novel system that combines brain organoid technology and intricate genetics, researchers can now comprehensively test the effect of multiple mutations in parallel and at a single-cell level within human brain organoids.

13 Sep 2023

Study helps explain why solid tumors often spread to the spine

The vertebral bones that form the spine are derived from a distinct type of stem cell that secretes a protein favoring tumor metastases, according to a study led by researchers at Weill Cornell Medicine.

13 Sep 2023

Researchers develop new protocol to study white matter injury in Alzheimer's disease

A new editorial paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 16, entitled, "Microvascular contributions to white matter injury in Alzheimer's disease."

13 Sep 2023

Training program for health workers aims to reduce the burden of breast cancer in Malawi

Women in rural Malawi are learning how to detect breast cancer thanks to the country's first dedicated training programme for health workers, aimed at reducing the burden of the disease.

12 Sep 2023

Scientists develop new method to detect key fat-filled particles in the brain

Scientists have created a method to detect key fat-filled particles known as lipoproteins in the central nervous system, opening a new view into the workings of the brain.

12 Sep 2023

Scientists identify malaria-causing parasites resistant to both treatment and detection in Ethiopia

Scientists have detected new strains of malaria-causing parasites in Ethiopia that are both resistant to current treatments and escape detection by common diagnostic tests - a development that could increase cases and deaths from malaria and make eliminating the persistent disease an even greater challenge.

11 Sep 2023

Study identifies cellular processes that likely lead to Parkinson's disease

Parkinson's disease, characterized by various motor dysfunctions, is the second most common neurodegenerative disorder in the world. It is known that specific gene mutations that are passed down through families are responsible for some cases of Parkinson's disease.

11 Sep 2023

Modified adenocarcinoma classification improves reproducibility and aligns with clinical reality

A modified adenocarcinoma classification approach significantly enhances reproducibility and may be an improvement on the existing World Health Organization classification system, according to research unveiled at the International Association for the Study of Lung Cancer (IASLC) 2023 World Conference on Lung Cancer in Singapore.

11 Sep 2023

Radiologist supported by AI can detect more cases of breast cancer, study shows

One radiologist supported by AI detected more cases of breast cancer in screening mammography than two radiologists working together, reports the ScreenTrustCAD study from Karolinska Institutet in The Lancet Digital Health.

8 Sep 2023

Irisin-based therapies may help combat Alzheimer’s disease

Researchers who previously developed the first 3D human cell culture models of Alzheimer's disease (AD) that displays two major hallmarks of the condition - the generation of amyloid beta deposits followed by tau tangles - have now used their model to investigate whether the exercise-induced muscle hormone irisin affects amyloid beta pathology.

8 Sep 2023

Pathology News and Research

Further Reading

St. Jude Children's researchers better define hyperdiploidy in childhood B-ALL

Early treatment with convalescent plasma may reduce risk of long COVID

AI-based tool can assess pathology slides to identify valuable features of clear cell renal cell carcinoma

Researchers identify key mechanisms to address future treatments for hereditary blindness

Single-cell screening of cerebral organoids to identify developmental defects in autism

BU researchers receive NIH grant to identify genetic factors for Alzheimer's disease

How does the APOE4 gene play both hero and villain in your health risks?

Innovative technique provides unparalleled insight into autism pathology

Study helps explain why solid tumors often spread to the spine

Researchers develop new protocol to study white matter injury in Alzheimer's disease

Training program for health workers aims to reduce the burden of breast cancer in Malawi

Scientists develop new method to detect key fat-filled particles in the brain

Scientists identify malaria-causing parasites resistant to both treatment and detection in Ethiopia

Study identifies cellular processes that likely lead to Parkinson's disease

Modified adenocarcinoma classification improves reproducibility and aligns with clinical reality

Radiologist supported by AI can detect more cases of breast cancer, study shows

Irisin-based therapies may help combat Alzheimer’s disease

The role of exercise-induced hormone irisin in amyloid beta reduction

Senolytic therapy in mild Alzheimer’s disease shows safety in phase I trial

A subset of CD8+ T cells can play a protective role against Alzheimer’s disease pathogenesis

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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