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New Canadian study investigates how cancer adapts its metabolism to overcome therapies

Knowing what cancer will do next could lessen the likelihood of it becoming resistant to treatment. A new Canadian study investigates how cancer adapts its metabolism to potentially overcome therapies still in development.

8 Jun 2020

Census of viral spike protein antigens could benefit development of SARS-CoV-2 therapeutics

A group of researchers has determined how different proteins associated with SARS-CoV-2 - the virus that causes COVID-19 - generate immune responses when given to rabbits as immunizations.

8 Jun 2020

Health disparities negatively impact various groups of people

Certain illnesses and diseases have the ability to affect various groups of people in detrimental ways.

8 Jun 2020

Chemotherapy and cancer join together to cause neuropathy

Contrary to common medical guidance, chemotherapy does not appear to be the only culprit in neuropathy, a neurological side effect of cancer treatment, a new study says. Cancer itself contributes heavily, too, and the stresses on neurons appear far worse than the sum of the two causes.

8 Jun 2020

Innovative algorithm helps select patients in need of urgent surgery or chemotherapy during COVID-19

A new approach to better select breast cancer patients in need of urgent surgery or chemotherapy during the COVID-19 pandemic has been developed by researchers at The Royal Marsden and the Breast Cancer Now Research Centre at The Institute of Cancer Research, London, in collaboration with colleagues in the UK, Germany and US.

8 Jun 2020

Research team identifies key ingredients for producing high-value chemical compounds

Researchers have identified key ingredients for producing high-value chemical compounds in an environmentally friendly fashion: repurposed enzymes, curiosity, and a little bit of light.

8 Jun 2020

Synthetic monoclonal antibodies effectively neutralize SARS-CoV-2 in laboratory conditions

In a new study available on the preprint server bioRxiv*, a multinational research group demonstrated how monoclonal antibodies strongly inhibit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro at even sub-nanomolar concentrations. This makes them a prime candidate for the treatment of coronavirus disease (COVID-19).

8 Jun 2020

SARS-CoV-2 infection causes specific kidney proximal tubular injury

SARS-CoV-2-associated acute kidney injury (AKI) is one of the more frequently encountered organ involvements in COVID-19 - in as many as 80% of critically ill patients, according to a recent study.

8 Jun 2020

New EUbOPEN consortium will enable access to research tools to unlock disease biology

Frankfurt and Ingelheim. Almost twenty years after deciphering the human genome, our understanding of human disease is still far from complete.

8 Jun 2020

Incidence of intracerebral hemorrhages increasing in older people, study finds

Brain bleeds called intracerebral hemorrhages remained stable in incidence among all age groups over the past 30 years, but they increased in people 75 and older, according to a new analysis of the Framingham Heart Study. The findings are in JAMA Neurology.

8 Jun 2020

Acute kidney injury in intensive-care COVID-19 patients

71 patients with severe lung injury were admitted to four intensive care units at Bordeaux University Hospital and their data were collected and evaluated over a period of six weeks (March/April 2020). AKI was defined using KDIGO criteria and ADQI according to the Acute Disease Quality Initiative (ADQI) 16 workgroup.

8 Jun 2020

Study uncovers link between psoriasis and joint disease

A team led by Case Western Reserve University School of Medicine researchers has made two major discoveries involving psoriasis, a chronic and debilitating skin disease with no known cure.

8 Jun 2020

Researchers identify enzyme essential for intestinal epithelial differentiation

The intestinal epithelium is the inner layer of the intestinal wall, which separates host tissue from the intestinal microbiota.

8 Jun 2020

Researchers discover important molecular mechanism of Charcot-Marie-Tooth disease

Charcot-Marie-Tooth (CMT) disease is the most common form of inherited neuropathies. A genetic mutation causes the insulating myelin layer of peripheral nerves to become progressively damaged, resulting in severe disabilities in the case of CMT type 4B, for instance.

8 Jun 2020

Scientists find way to prevent warmed-up vaccines from degrading

Vaccines are notoriously difficult to transport to remote or dangerous places, as they spoil when not refrigerated.

8 Jun 2020

Using antibodies to detect Alzheimer’s disease

News-Medical speaks to Professor Vendruscolo about his research that uses antibodies to detect Alzheimer's disease, which could help to improve drug discovery.

8 Jun 2020

Monocytes could be critical in dysregulated immunity in COVID-19

A new study by Spanish researchers as part of the GEN-COVID Project, and published on the preprint server medRxiv* in June 2020, suggests that monocytes are primarily involved in triggering the hyperinflammatory immune response that may underlie severe COVID-19 infection.

8 Jun 2020

The receptor binding domain of the SARS-CoV-2

With the spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) across most of the world, scientists are working strenuously to find effective therapies or vaccines. Most strategies being worked on at present are targeting viral entry into the host cells, mainly through the interaction of the SARS-CoV-2 S protein with the angiotensin-converting enzyme 2 (ACE2) receptor.

8 Jun 2020

Inhibition of coronavirus spike protein binding to ACE2

A novel coronavirus, CoV-19, and a later phenotype CoV-2 were identified as the primary cause for severe acute respiratory syndrome (SARS CoV-2). The spike (S) protein of CoV-2 is one target for the development of a vaccine to prevent the viral entry into human cells. The inhibition of the direct interaction between ACE2 and the S-protein could provides a suitable strategy to prevent the membrane fusion of CoV-2 and the viral entry into human cells. Using MD simulations, we investigate the assembly process of a Coronavirus Spike protein fragment, the hexapeptide YKYRYL on the ACE2 receptor and its inhibitzory effect on the aggregation and activation of the CoV-2 spike receptor protein at the same receptor protein.

8 Jun 2020

SARS-CoV-2 genome variants in India

A new study published online on the preprint server bioRxiv in June 2020 surveys the genetic diversity of SARS-CoV-2 strains in India.

7 Jun 2020

Protein C News and Research

New Canadian study investigates how cancer adapts its metabolism to overcome therapies

Census of viral spike protein antigens could benefit development of SARS-CoV-2 therapeutics

Health disparities negatively impact various groups of people

Chemotherapy and cancer join together to cause neuropathy

Innovative algorithm helps select patients in need of urgent surgery or chemotherapy during COVID-19

Research team identifies key ingredients for producing high-value chemical compounds

Synthetic monoclonal antibodies effectively neutralize SARS-CoV-2 in laboratory conditions

SARS-CoV-2 infection causes specific kidney proximal tubular injury

New EUbOPEN consortium will enable access to research tools to unlock disease biology

Incidence of intracerebral hemorrhages increasing in older people, study finds

Acute kidney injury in intensive-care COVID-19 patients

Study uncovers link between psoriasis and joint disease

Researchers identify enzyme essential for intestinal epithelial differentiation

Researchers discover important molecular mechanism of Charcot-Marie-Tooth disease

Scientists find way to prevent warmed-up vaccines from degrading

Using antibodies to detect Alzheimer’s disease

Monocytes could be critical in dysregulated immunity in COVID-19

The receptor binding domain of the SARS-CoV-2

Inhibition of coronavirus spike protein binding to ACE2

SARS-CoV-2 genome variants in India

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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