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Computer model shows how cancerous tumors manipulate blood-vessel growth for their own benefit

Rice University researchers have built a simulation to show how cancerous tumors manipulate blood-vessel growth for their own benefit.

9 Jul 2015

LUX-Lung 8 supports afatinib in squamous NSCLC

Compared with erlotinib, treatment with afatinib leads to outcomes in previously treated patients with advanced squamous non-small-cell lung cancer, suggest the results of a head-to-head trial.

8 Jul 2015

DME treatment evolves in favour of intravitreal anti-VEGF injections

Treatment strategies for diabetic macular oedema have evolved over the past decade, with focal laser therapy being largely replaced by intravitreal injections, an observational case series of more than 1500 patients shows.

8 Jul 2015

Macular atrophy predicts vision in ranibizumab-treated exudative AMD patients

Progression and severity of macular atrophy are the main anatomical determinants of long-term visual outcomes in exudative age-related macular degeneration patients treated with ranibizumab, suggest SEVEN-UP study results.

8 Jul 2015

Darapladib shows promise in diabetic macular oedema

Placebo-controlled trial findings show that lipoprotein-associated phospholipase A2 inhibition modestly benefits the vision of patients with centre-involved diabetic macular oedema and warrants further investigation.

8 Jul 2015

UC researcher awarded NCI grant to study effect of MED1 protein on HER2-positive breast cancer

Xiaoting Zhang, PhD, associate professor in the Department of Cancer Biology at the University of Cincinnati College of Medicine, has received a $1.8 million, five-year, R01 award (R01CA197865) from the National Cancer Institute to continue breast cancer research focusing on the function of the protein MED1 on HER2-positive breast cancer.

8 Jul 2015

Polypoidal choroidal vasculopathy shows distinct classification

Researchers have found that idiopathic polypoidal choroidal vasculopathy has significant clinical differences to neovascular age-related macular degeneration and suggest that it should be considered a distinct entity.

30 Jun 2015

ORT incidence increases in nAMD despite anti-VEGF treatment

Swiss researchers report that patients with neovascular age-related macular degeneration (nAMD) experience increased incidence of outer retinal tubulation over time, despite treatment with a vascular endothelial growth factor blocker.

30 Jun 2015

Case report published on first use of 3D printed scaffold for periodontal tissue engineering

Today, the International and American Associations for Dental Research published a case report on the first application of a 3D printed scaffold for periodontal tissue engineering in a human patient, along with a review of 3D printing for oral and craniofacial tissue engineering.

30 Jun 2015

Neuralstem's HK532-IGF-1 neural stem cells therapy for Alzheimer's disease presented at ISSCR Annual Meeting

Neuralstem, Inc., a biopharmaceutical company using neural stem cell technology to develop small molecule and cell therapy treatments for central nervous system diseases, announced that the poster "Human Neural Stem Cells Expressing IGF-1: A Novel Cellular Therapy for Alzheimer's Disease" was presented yesterday at the International Society for Stem Cell Research (ISSCR) Annual Meeting in Stockholm, Sweden.

27 Jun 2015

No overall survival benefit for bevacizumab in ovarian cancer

Addition of bevacizumab to first-line platinum-based chemotherapy does not improve overall survival in women with ovarian cancer, according to the mature data of the ICON7 trial.

26 Jun 2015

Penn Medicine scientists identify stem-like 'progenitor' cell that produces heart muscle cells

Future therapies for failing hearts are likely to include stem-like cells and associated growth factors that regenerate heart muscle. Scientists from the Perelman School of Medicine at the University of Pennsylvania have just taken an important step towards that future by identifying a stem-like "progenitor" cell that produces only heart muscle cells.

26 Jun 2015

UC Santa Barbara professor develops novel therapeutic strategy for PKD

For the 12 million people worldwide who suffer from polycystic kidney disease (PKD), an inherited disorder with no known cure, a new treatment option may be on the horizon.

26 Jun 2015

Alabama scientists show how phytochemical in magnolia works against head and neck cancers

Magnolias are prized for their large, colorful, fragrant flowers. Does the attractive, showy tree also harbor a potent cancer fighter?

26 Jun 2015

Selective use of biomarker testing for breast cancer patients can save millions of dollars in health care spending

A review of medical records for almost 200 patients with breast cancer suggests that more selective use of biomarker testing for such patients has the potential to save millions of dollars in health care spending without compromising care, according to Johns Hopkins researchers.

23 Jun 2015

New study reports more practical approach to heal the heart after a heart attack

Stem cell have been the main focus of healing therapy research because they can morph into new cells, and using a patient's own stem cells will not induce an autoimmune response. For healing after a heart attack, the ideal time to administer these therapies is when reopening the clogged blood vessel because the heart is easily accessible. While stem cells show promise for heart attack treatment, the process of harvesting and reintroducing the cells—which can take days or weeks—is too slow for this window.

17 Jun 2015

NCCN ORP receives $2-million grant from Boehringer Ingelheim to facilitate studies of afatinib in NSCLC

The National Comprehensive Cancer Network Oncology Research Program (ORP) has been awarded a $2-million grant from Boehringer Ingelheim Pharmaceuticals, Inc. to develop a program to evaluate scientifically targeted combination approaches with afatinib in the treatment of non-small cell lung cancer (NSCLC).

12 Jun 2015

SQUIRE phase III study shows necitumumab improves median overall survival in squamous NSCLC patients

This week, Lancet Oncology reports results of a 1,093-person phase III clinical trial of the drug necitumumab (IMC-11F8) combined with chemotherapies gemcitabine and cisplatin against stage IV squamous non-small cell lung cancer. With addition of necitumumab, median overall survival was 11.5 months compared with median survival of 9.9 months with the two chemotherapies alone.

11 Jun 2015

Phase II clinical trial of Linsitinib launched in patients with advanced Ewing sarcoma

EUROSARC, European Clinical trials in Rare Sarcomas within an integrated translational trial network, has launched a phase II trial of Linsitinib for patients with relapsed and/or refractory Ewing Sarcoma. The trial, EORTC 1225 / OCTO 038, aims to establish pharmacodynamic responses in Ewing sarcoma tumors to Linsitinib using functional imaging and biopsies, and toxicity and clinical outcomes.

9 Jun 2015

New technique slows progression of polycystic kidney disease in mice

A new technique for treating polycystic kidney disease has been identified by researchers based at the UCL Institute of Child Health. Published in the Journal of the American Society of Nephrology, the treatment, which involves targeting tiny blood and lymphatic vessels inside the kidneys, is shown to improve renal function and slow progression of disease in mice.

8 Jun 2015

Growth Factor News and Research

Computer model shows how cancerous tumors manipulate blood-vessel growth for their own benefit

LUX-Lung 8 supports afatinib in squamous NSCLC

DME treatment evolves in favour of intravitreal anti-VEGF injections

Macular atrophy predicts vision in ranibizumab-treated exudative AMD patients

Darapladib shows promise in diabetic macular oedema

UC researcher awarded NCI grant to study effect of MED1 protein on HER2-positive breast cancer

Polypoidal choroidal vasculopathy shows distinct classification

ORT incidence increases in nAMD despite anti-VEGF treatment

Case report published on first use of 3D printed scaffold for periodontal tissue engineering

Neuralstem's HK532-IGF-1 neural stem cells therapy for Alzheimer's disease presented at ISSCR Annual Meeting

No overall survival benefit for bevacizumab in ovarian cancer

Penn Medicine scientists identify stem-like 'progenitor' cell that produces heart muscle cells

UC Santa Barbara professor develops novel therapeutic strategy for PKD

Alabama scientists show how phytochemical in magnolia works against head and neck cancers

Selective use of biomarker testing for breast cancer patients can save millions of dollars in health care spending

New study reports more practical approach to heal the heart after a heart attack

NCCN ORP receives $2-million grant from Boehringer Ingelheim to facilitate studies of afatinib in NSCLC

SQUIRE phase III study shows necitumumab improves median overall survival in squamous NSCLC patients

Phase II clinical trial of Linsitinib launched in patients with advanced Ewing sarcoma

New technique slows progression of polycystic kidney disease in mice

Industry Focus eBook - Life Science Microscopy (2nd Edition) eBook

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

How microplastics and bacteria interact to drive antibiotic resistance

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