Metabolite News and Research

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Metabolites are the intermediates and products of metabolism. The term ''metabolite'' is usually restricted to small molecules.

Estrogen may influence the risk for prostate cancer

Although women are four times more likely than men to develop osteoporosis, or porous bone, one in 12 men also suffer from the disease, which can lead to debilitating - or even life-threatening - fractures, mainly of the spine, hip and wrist.

11 May 2007

Recommended doses of ginseng, ginko biloba do not interfere with drug absorption

Recent findings that the widely-used herbal supplement Saint John's wort could dramatically affect the absorption and metabolism of many prescription and non-prescription drugs raised concerns that other popular herbal supplements might cause similar changes, thus significantly altering drugs, therapeutic or toxic effects.

2 May 2007

New human medications found in fish in Texas

Baylor University researchers have found the residue of three new human medications in fish living in the Pecan Creek in North Texas.

2 May 2007

Chronic alcohol consumption increases tumor growth and amgiogenesis of breast cancer in female mice

For the first time, scientists have used a laboratory mouse model to mimic the development of human alcohol-induced breast cancer.

30 Apr 2007

Anadys Pharmaceuticals presents data showing ANA773 promotes anti-tumor activity of killer cells

Anadys Pharmaceuticals presented data from an in vitro study showing that the active metabolite of ANA773 promotes natural killer (NK) cell-mediated anti-tumor response by inducing cytokine secretion, cytolysis of tumor cells and enhanced antibody-dependent cellular cytotoxicity (ADCC), during a poster presentation at the Annual Meeting of the American Association of Cancer Research (AACR) in Los Angeles.

18 Apr 2007

New device to test for proteins that play important role in human health and disease

A new technology developed at the University of Toronto is revealing biochemical processes responsible for diseases such as cystic fibrosis and could one day pave the way for pharmaceutical applications.

15 Apr 2007

LaeA gene shown to be an ideal prospect for new ways to fight infection

For the growing number of people with diminished immune systems - cancer patients, transplant recipients, those with HIV/AIDS - infection by a ubiquitous mold known as Aspergillus fumigatus can be a death sentence.

15 Apr 2007

Exposure to phthalates linked to abdominal obesity and insulin resistance in adult males

Exposure to phthalates, a common chemical found in everything from plastics to soaps, already has been connected to reproductive problems and now, for the first time, is linked to abdominal obesity and insulin resistance in adult males, according to a study by the University of Rochester Medical Center.

14 Mar 2007

Race affects passive smoke absorption in children

New research suggests that a child's race may be a factor in determining his/her susceptibility to tobacco toxins associated with environmental tobacco smoke (ETS).

13 Mar 2007

Dissecting secret formula of nectar

The sugar-containing nectar secreted by plants and consumed by pollinators shares a number of similarities to fitness drinks, including ingredients such as amino acids and vitamins. In addition to these components, nectar can also contain secondary metabolites such as the alkaloid nicotine and other toxic compounds.

27 Feb 2007

Expert questions validity of genetic testing patents

Molecular Pathologist-Attorney Roger D. Klein in a letter published in the February 15, 2007 issue of the New England Journal of Medicine questioned the validity of patents often used to prevent clinical laboratories from performing certain genetic tests.

20 Feb 2007

Twin study on the increased cardiometabolic risk in obesity

A unique monozygotic twin study by researchers from the Finnish Twin Cohort, Helsinki University Central Hospital, and VTT Technical Research Centre of Finland found that obesity, already in its early stages and independent of genetic influences, is associated with deleterious alterations in the lipid metabolism known to facilitate atherogenesis, inflammation and insulin resistance.

15 Feb 2007

Indicators for risk of heart disease are higher in passive smokers

Exposure to second-hand smoke at work, home or elsewhere results in a disproportionate rise in markers that increase the risk of cardiovascular disease, University of Nottingham researchers have found.

12 Feb 2007

New dynamic view of protein dynamics

Scientists from the Institute for Research in Biomedicine (IRB Barcelona), the Life Sciences Programme at the Barcelona Supercomputing Center (BSC) and the National Institute for Bioinformatics (INB) have published a provisional "atlas" of the dynamic behaviour of proteins in the prestigious scientific journal, Proceedings of the National Academy of Sciences.

9 Jan 2007

New study emphasizes the importance of metabolomics to the advent of personalized medicine

International experts have collaborated on a comprehensive collection of reviews focusing on the emerging interface between metabolomics and pharmacogenomics.

24 Oct 2006

Flexible interface between DNA ligase and a heterotrimeric sliding clamp supports conformational switching and efficient ligation of DNA

Scientists investigating an important DNA-repair enzyme now have a better picture of the final steps of a process that glues together, or ligates, the ends of DNA strands to restore the double helix.

20 Oct 2006

An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling

Using a combination of enzyme activity and metabolite profiling, we determined that this protein-whose function was previously unknown-serves as a key regulator of a lipid signaling network that contributes to cancer," said Benjamin F. Cravatt, a Scripps Research professor and a member of its Skaggs Institute for Chemical Biology who led the study.

20 Oct 2006

$74 million allocated to study environmental causes of disease

As part of the new Exposure Biology Program, the National Institute of Environmental Health Sciences, a component of the National Institutes of Health, today announced $74 million in grant opportunities for the development of new technologies that will improve the measurement of environmental exposures that contribute to human disease.

19 Oct 2006

Progesterone improves outcomes for victims of traumatic brain injury

A new study suggests that giving progesterone to victims with Traumatic Brain Injury (TBI) shortly following brain injury may reduce the risk of death and the degree of disability, and appears to be safe.

3 Oct 2006

Licensing arrangement reached for antiepileptic drug developed at Hebrew University

A worldwide licensing arrangement for development, production and marketing of an antiepileptic drug created at the Hebrew University of Jerusalem has been signed by Shire Pharmaceuticals with Yissum, the Hebrew University's technology transfer company.

5 Sep 2006

Metabolite News and Research

Further Reading

Estrogen may influence the risk for prostate cancer

Recommended doses of ginseng, ginko biloba do not interfere with drug absorption

New human medications found in fish in Texas

Chronic alcohol consumption increases tumor growth and amgiogenesis of breast cancer in female mice

Anadys Pharmaceuticals presents data showing ANA773 promotes anti-tumor activity of killer cells

New device to test for proteins that play important role in human health and disease

LaeA gene shown to be an ideal prospect for new ways to fight infection

Exposure to phthalates linked to abdominal obesity and insulin resistance in adult males

Race affects passive smoke absorption in children

Dissecting secret formula of nectar

Expert questions validity of genetic testing patents

Twin study on the increased cardiometabolic risk in obesity

Indicators for risk of heart disease are higher in passive smokers

New dynamic view of protein dynamics

New study emphasizes the importance of metabolomics to the advent of personalized medicine

Flexible interface between DNA ligase and a heterotrimeric sliding clamp supports conformational switching and efficient ligation of DNA

An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling

$74 million allocated to study environmental causes of disease

Progesterone improves outcomes for victims of traumatic brain injury

Licensing arrangement reached for antiepileptic drug developed at Hebrew University

Industry Focus eBook - Cell biology (5th edition) eBook

Latest eBooks

Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

Advancing degrader and proximity-based drug development

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo