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Three-way strategy employed by SARS-CoV-2 during infection

The study, published in the journal Nature, reveals a multi-pronged strategy that the virus employs to ensure its quick and efficient replication while evading the immune system. The study elucidated how the virus can quickly, in a matter of hours, take over the cell's protein-making machinery and parallelly neutralize the cell's antiviral signaling, thus delaying and muddling the immune response.

13 May 2021

Novel nanotechnology could change the lives of people living with cystic fibrosis

World-first nanotechnology developed by the University of South Australia could change the lives of thousands of people living with cystic fibrosis (CF) as groundbreaking research shows it can improve the effectiveness of the CF antibiotic Tobramycin, increasing its efficacy by up to 100,000-fold.

13 May 2021

Certain immune cells unexpectedly change their behavior to cause psoriasis lesions

Millions of people suffer from psoriasis, a chronic, autoimmune disorder that causes scaly patches on the skin and often precedes psoriatic arthritis. While no cure exists, treatments range from topical creams to injected medications that block inflammation.

13 May 2021

NK cells combined with bispecific antibody display potent anti-tumor activity against lymphoma cells

Cytokine-activated natural killer (NK) cells derived from donated umbilical cord blood, combined with an investigational bispecific antibody targeting CD16a and CD30 known as AFM13, displayed potent anti-tumor activity against CD30+ lymphoma cells, according to a new preclinical study from researchers at The University of Texas MD Anderson Cancer Center.

13 May 2021

Phosphatidic acid is a key common substrate for hepatitis C and SARS-CoV-2 replication

A new study, released as a preprint on the bioRxiv* server, focuses on the lipid molecule called phosphatidic acid (PA), showing its crucial role in the replication of this virus, and thus its potential as a target for therapeutic intervention.

13 May 2021

High-density microarray patch could help vaccinate for dengue in a single click

A dengue virus vaccine candidate has passed an important milestone, with promising results in animal model testing providing hope to the 390 million people infected every year.

13 May 2021

Designer SARS-CoV-2 RBD vaccine produces dramatically improved antibody response in preclinical trials

The importance of computational modeling in the prediction of the course of the ongoing COVID-19 pandemic, as well as evaluating multiple potential drug leads, has never been more clear. Now, a new study describes a set of designer vaccine antigens that may improve vaccine stability as well as enhance the neutralizing antibody response.

13 May 2021

Obesity-related cancer deaths are declining at a slower pace, shows study

Cancer death rates have fallen dramatically in the United States, but factor in obesity, as researchers did at the University of North Carolina Gillings School of Global Public Health, and the picture changes.

13 May 2021

Study reports new monoclonal antibodies with broad neutralizing capabilities against betacoronaviruses (including SARS-CoV-2)

In a paper published on the bioRxiv* preprint server, researchers report new monoclonal antibodies that target the S2 subunit and that have broad neutralization activity against several betacoronaviruses.

13 May 2021

SARS-CoV-2 virus uses a multipronged strategy to avoid detection by the immune system

Severe symptoms of COVID-19, leading often to death, are thought to result from the patient's own acute immune response rather than from damage inflicted directly by the virus.

13 May 2021

Comprehensive blood atlas of COVID-19 identifies hallmarks of disease severity

Researchers in the UK have presented a multi-omics integrated blood atlas that delineates the host immune response in patients with coronavirus disease 2019 (COVID-19) of varying severity, providing a unique reference resource for the interpretation of datasets generated from interventional trials.

13 May 2021

Pfizer-BioNTech COVID-19 vaccine effective in patients with myeloproliferative neoplasms

Researchers in the UK have provided evidence that Pfizer-BioNTech’s coronavirus disease 2019 (COVID-19) vaccine induces effective immune responses in patients with myeloproliferative neoplasms.

13 May 2021

New study may help develop senolytic drugs that target senescent immune cells

In a study recently published in Nature University of Minnesota Medical School researchers found that senescent immune cells are the most dangerous type of senescent cell.

13 May 2021

Researchers identify six “words” used by specific immune cells to call up immune defense genes

UCLA life scientists have identified six "words" that specific immune cells use to call up immune defense genes -- an important step toward understanding the language the body uses to marshal responses to threats.

13 May 2021

Scientists unveil new Ebola virus vaccine design

Scientists at Scripps Research have unveiled a new Ebola virus vaccine design, which they say has several advantages over standard vaccine approaches for Ebola and related viruses that continue to threaten global health.

13 May 2021

Research provides new insight into anesthesia-associated tau spreading in the brain

During the development and progression of Alzheimer's disease, a protein called tau accumulates and spreads in the brain.

12 May 2021

AI helps assess patient's risk of regenerative outcomes after treatment of peri-implantitis

Peri-implantitis, a condition where tissue and bone around dental implants becomes infected, besets roughly one-quarter of dental implant patients, and currently there's no reliable way to assess how patients will respond to treatment of this condition.

12 May 2021

New method to efficiently deliver drugs into cells

A new, patented method called Progressive Mechanoporation makes it possible to mechanically disrupt the membranes of cells for a short time period and let drugs or genes inside cells.

12 May 2021

New peptide could allow cannabis to fight pain without side effects

Many people live with chronic pain, and in some cases, cannabis can provide relief. But the drug also can significantly impact memory and other cognitive functions.

12 May 2021

Study could help understand how Tuberous Sclerosis Complex arises

Tuberous Sclerosis Complex (TSC) affects between one and two of every 10,000 new-born babies. This genetic disease leads to the formation of benign tumors which can massively impair the proper functioning of vital organs such as the kidneys, the liver and the brain.

12 May 2021

B Cell News and Research

Three-way strategy employed by SARS-CoV-2 during infection

Novel nanotechnology could change the lives of people living with cystic fibrosis

Certain immune cells unexpectedly change their behavior to cause psoriasis lesions

NK cells combined with bispecific antibody display potent anti-tumor activity against lymphoma cells

Phosphatidic acid is a key common substrate for hepatitis C and SARS-CoV-2 replication

High-density microarray patch could help vaccinate for dengue in a single click

Designer SARS-CoV-2 RBD vaccine produces dramatically improved antibody response in preclinical trials

Obesity-related cancer deaths are declining at a slower pace, shows study

Study reports new monoclonal antibodies with broad neutralizing capabilities against betacoronaviruses (including SARS-CoV-2)

SARS-CoV-2 virus uses a multipronged strategy to avoid detection by the immune system

Comprehensive blood atlas of COVID-19 identifies hallmarks of disease severity

Pfizer-BioNTech COVID-19 vaccine effective in patients with myeloproliferative neoplasms

New study may help develop senolytic drugs that target senescent immune cells

Researchers identify six “words” used by specific immune cells to call up immune defense genes

Scientists unveil new Ebola virus vaccine design

Research provides new insight into anesthesia-associated tau spreading in the brain

AI helps assess patient's risk of regenerative outcomes after treatment of peri-implantitis

New method to efficiently deliver drugs into cells

New peptide could allow cannabis to fight pain without side effects

Study could help understand how Tuberous Sclerosis Complex arises

Industry focus eBook - Cell and gene therapy (2nd edition) eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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