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Cyanotriazole compounds can selectively and rapidly kill trypanosome parasites, study shows

Cyanotriazole compounds are fast-acting topoisomerase II poisons that can selectively and rapidly kill trypanosome parasites that cause Chagas disease and African sleeping sickness, according to a new study.

29 Jun 2023

Scientists use designer tubulins to crack the tubulin code

Tubulin is a protein that plays a crucial role in the structure and function of cells. It is the main component of microtubules, which are long, hollow fibers that provide structural support, help the cell divide, give it its shape, and act as tracks for moving molecular cargo around inside the cell.

29 Jun 2023

Duke researchers expand functionality of CRISPR gene editing

CRISPR gene editing is a breakthrough that has been used to treat diseases such as sickle cell anemia, leukemia and genetic disorders, but it has challenges that limit its broad utility.

29 Jun 2023

Study shows promising prospects for automating 3D-DSRT in drug testing

The June 2023 issue of SLAS Discovery contains one review article, five full-length articles and two technical briefs covering spheroid models, 3D cell high-throughput screening (HTS) applications for treating Alzheimer's and other drug discovery research.

29 Jun 2023

Researchers screen 16 UK native bat species for coronaviruses with zoonotic potential

A recent study published in Nature Communications screened for coronaviruses in 16 native species of bats in the UK.

29 Jun 2023

Study suggests blood group A may directly influence SARS-CoV-2 infectious risk

Researchers evaluated the association between blood group A and SARS-CoV-2 infections.

29 Jun 2023

Understanding the biological effects of SARS-CoV-2 persistence in children

Researchers analyzed the most recent knowledge about severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

29 Jun 2023

Elucidating the role of the gut-brain-axis in autism

The study investigates the relationship between the gut and the brain in autism spectrum disorder (ASD), identifying microbial profiles and metabolic products associated with ASD phenotypes, dietary patterns, and inflammation. The findings provide insights into the role of the gut-brain axis in ASD and its potential impact on understanding and managing the disorder.

28 Jun 2023

Novel anti-cancer drug found to sensitize tumor cells to ferroptosis

A team of researchers led by Dr. Marcus Conrad from Helmholtz Munich discovered a novel anti-cancer drug, called icFSP1, which sensitizes cancer cells to ferroptosis.

28 Jun 2023

First programmable RNA-guided system found in eukaryotes

A team of researchers led by Feng Zhang at the Broad Institute of MIT and Harvard and the McGovern Institute for Brain Research at MIT has uncovered the first programmable RNA-guided system in eukaryotes - organisms that include fungi, plants, and animals.

28 Jun 2023

Newly identified enzyme could be a useful tool for creating anticancer drugs

Many of the drugs we use to treat cancer and infectious disease are ⎯ or derive from ⎯ natural products, but it's difficult to know exactly how nature assembles them.

27 Jun 2023

New research shows antibody cross-reactivity between human and animal coronaviruses

Researchers probed for antibody binding against all seven human coronaviruses (hCoVs).

27 Jun 2023

ACEI therapy decreases the incidence of cardiac rupture after acute myocardial infarction

Announcing a new article publication for Cardiovascular Innovations and Applications journal. ACEI therapy decreases mortality in patients with acute MI.

26 Jun 2023

Study reveals how SARS-CoV-2 variants lose Infectivity in aerosols: pH and salt content key factors

Research examines the stability of SARS-CoV-2 variants in aerosols, finding significant decay in infectivity over time. pH and salt content play a role in virus stability.

26 Jun 2023

Prior exposure to air pollutants and black carbon load predicts outcomes in hospitalized COVID-19 patients

Researchers investigated whether black carbon particles in the blood increased COVID-19 severity.

23 Jun 2023

Deciphering a biochemical mechanism explains the center of protein factories

Based on genetic blueprints, individual amino acids are assembled into long amino acid chains, the proteins, in the protein factories of our cells, the ribosomes. Each newly formed protein starts with the amino acid methionine.

23 Jun 2023

Pangolin study uncovers novel strains of coronaviruses and raises concerns about origin

Researchers identify novel HKU4-related coronavirus in a pangolin single-cell sequencing dataset.

22 Jun 2023

Study reveals contrasting effects of sucralose on insulin and glucose control

Sucralose, a commonly used artificial sweetener, has contrasting effects on insulin secretion and glucose homeostasis. While bolus administration of sucralose enhances insulin secretion and decreases glucose levels, long-term consumption exacerbates insulin resistance and glucose intolerance, particularly in combination with a high-fat diet. The study highlights the involvement of the T1R3-ERK1/2 pathway in sucralose-induced insulin resistance in the liver.

22 Jun 2023

The link between Covid-19 and Alzheimer's disease established

Renin-angiotensin system, or RAS, is a physiological mechanism essential to human body function. The SARS-CoV-2 virus causes overactivation and malfunction of this system.

21 Jun 2023

Repurposed drug effective at inhibiting a protein kinase linked to cardiac arrhythmias

Ruxolitinib, a drug that is already approved by the U.S. Food and Drug Administration (FDA) for treating certain cancers and skin conditions, is effective at inhibiting CaMKII, a protein kinase linked to cardiac arrhythmias.

21 Jun 2023

Enzyme News and Research

Cyanotriazole compounds can selectively and rapidly kill trypanosome parasites, study shows

Scientists use designer tubulins to crack the tubulin code

Duke researchers expand functionality of CRISPR gene editing

Study shows promising prospects for automating 3D-DSRT in drug testing

Researchers screen 16 UK native bat species for coronaviruses with zoonotic potential

Study suggests blood group A may directly influence SARS-CoV-2 infectious risk

Understanding the biological effects of SARS-CoV-2 persistence in children

Elucidating the role of the gut-brain-axis in autism

Novel anti-cancer drug found to sensitize tumor cells to ferroptosis

First programmable RNA-guided system found in eukaryotes

Newly identified enzyme could be a useful tool for creating anticancer drugs

New research shows antibody cross-reactivity between human and animal coronaviruses

ACEI therapy decreases the incidence of cardiac rupture after acute myocardial infarction

Study reveals how SARS-CoV-2 variants lose Infectivity in aerosols: pH and salt content key factors

Prior exposure to air pollutants and black carbon load predicts outcomes in hospitalized COVID-19 patients

Deciphering a biochemical mechanism explains the center of protein factories

Pangolin study uncovers novel strains of coronaviruses and raises concerns about origin

Study reveals contrasting effects of sucralose on insulin and glucose control

The link between Covid-19 and Alzheimer's disease established

Repurposed drug effective at inhibiting a protein kinase linked to cardiac arrhythmias

Measuring Drug-Target Residence Times with Biochemical Assays eBook

Latest eBooks

Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

Advancing degrader and proximity-based drug development

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo