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Key genetic factor determines HIV/AIDS risk

People with more copies of a gene that helps to fight HIV are less likely to become infected with the virus or to develop AIDS than those of the same geographical ancestry, such as European Americans, who have fewer copies of the gene, according to a study funded by the National Institute of Allergy and Infectious Diseases (NIAID).

10 Jan 2005

Ascorbic acid doesn't seem to help physical exercise performance

Orange juice or other sources of vitamin C (ascorbic acid), may (or may not) benefit you in terms of health and exercise, but contrary to what many people thought previously, ascorbic acid doesn't seem to help physical exercise performance.

6 Jan 2005

Discovery could lead to a screening test that identifies people who have a higher or lower susceptibility to HIV/AIDS

6 Jan 2005

Processes shed light on how DNA recombination mechanisms are related

Peter W. Atkinson, a University of California, Riverside professor of entomology and member of the university’s Institute for Integrative Genome Biology, is part of a team that has linked the movement of small pieces of DNA, known as transposable elements, to a process called V(D)J recombination that produces the genetic diversity responsible for the production of antibodies.

6 Jan 2005

Direct modulation of progesterone signaling appears to influence ovarian cancer risk

A woman's risk of ovarian cancer rises significantly if she carries either of two previously unexamined variations in the gene that codes for the progesterone receptor, according to a team of researchers led by scientists from the Keck School of Medicine of the University of Southern California.

5 Jan 2005

Signaling molecule involved in osteoarthritis identified

Using naturally-occurring mutant mice with a defective collagen gene, scientists at Harvard have identified a signaling molecule involved in one of the most common causes of disability among the elderly in the United States, osteoarthritis.

4 Jan 2005

Exposure to the chemical BPA (Bisphenol A) stimulates prostate cancer cell growth

An estrogen-like chemical commonly used to synthesize plastic food containers has been shown to encourage the growth of a specific category of prostate cancer cell, potentially affecting the treatment efficacy for a subset of prostate cancers.

4 Jan 2005

Study shows women with invasive lobular carcinoma may not need chemotherapy before surgery

Women with a rare type of advanced breast cancer who do not benefit from primary (pre-surgical) chemotherapy still have been found to do better in the long run than patients with a more common advanced breast cancer who do respond to chemotherapy.

3 Jan 2005

Ubiquitination protects against improper Notch signaling

The Notch pathway is an important molecular signaling mechanism whose existence has been known, or at least hinted at, for nearly a century since the identification of a mutant strain of Drosophila fruit flies with "notched" wings in Thomas Hunt Morgan's lab in 1910.

28 Dec 2004

New findings clarify the role of NOD2, a key molecular player in Crohn's Disease

This week, researchers report new findings that clarify the role of NOD2, a key molecular player in Crohn's Disease, in the cellular signaling pathways that control inflammatory responses. NOD2's clinical relevance is clear from the fact that it is encoded by a Crohn's Disease susceptibility gene.

28 Dec 2004

FDA approves Enablex for the treatment of overactive bladder

Novartis Pharmaceuticals Corporation today announced that the U.S. Food and Drug Administration (FDA) has approved Enablex® (darifenacin) extended-release tablets (7.5mg and 15mg) for the treatment of overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency and frequency.

22 Dec 2004

Theory that could help to cure diseases including cancer

An Open University science student has astonished the world of medicine with a theory that could help to cure diseases including cancer.

21 Dec 2004

Stem cells use inflammatory signals to find injured tissue

A joint effort led by stem cell biologist Evan Y. Snyder, M.D., Ph.D., of The Burnham Institute, and Samia J. Khoury, M.D., of Harvard Medical School and Brigham and Women’s Hospital, report data suggesting that stem cells use inflammatory signals to “know” where they must home.

20 Dec 2004

Detrol LA significantly reduces symptoms of overactive bladder

Pfizer today announced results of a comprehensive six-year review of efficacy and safety data for Detrol LA (tolterodine tartrate extended release capsules) indicating that Detrol LA significantly reduces symptoms of overactive bladder (OAB) with a low occurrence of side effects, and should be considered first-line therapy.

13 Dec 2004

New approach to genomic testing identifies women with low risk of breast cancer recurrence

An initial validation study presented by Exagen Diagnostics at the San Antonio Breast Cancer Symposium suggests it may soon be possible to distinguish good prognosis from poor prognosis in any newly diagnosed breast cancer patient based on DNA changes in the patient's tumor.

13 Dec 2004

Women over the age of 60 with low-risk breast cancer may not need to receive radiation therapy after surgery

The current treatment standard recommended for most women with early stage breast cancer is breast conservation therapy, consisting of lumpectomy following by radiotherapy. The purpose of the radiotherapy is to kill any tumor cells in the remaining breast area that may have been missed by the surgery.

13 Dec 2004

Findings could lead to new knowledge that could speed the development of drugs to block botulism or tetanus toxins more rapidly

The first detailed structure of a botulism toxin attached to its target protein reveals that the toxin snakes the protein around itself — a sort of “reverse anaconda” — to recognize the receptor.

13 Dec 2004

Study of early stage breast cancer patients identifies women at low risk of breast cancer mortality

Kaiser Permanente researchers are presenting results of a large epidemiologic study of a unique breast cancer test at the 27th Annual San Antonio Breast Cancer Symposium. The KP study shows the test can identify patients with early stage disease who are at low risk of breast cancer death at 10-years.

13 Dec 2004

Using precise, radioactively labeled genetic probes, researchers study cancer gene activity from outside the body

Using precise, radioactively labeled genetic probes, researchers at Jefferson Medical College have seen cancer gene activity from outside the body in laboratory mice. The probes, which work by attaching to genetic codes copied from an active cancer gene, may someday aid physicians and scientists in cancer detection and in determining the appropriate treatment for a cancer.

13 Dec 2004

Celecoxib may regulate a cell's use of estrogen - might help explain the drug's anticancer properties

Six months of treatment with celecoxib (Celebrex) in women at risk of developing breast cancer results in the reduction of estrogen receptor expression in breast cells, a research team at The University of Texas M. D. Anderson Cancer Center has found.

13 Dec 2004

Receptor News and Research

Key genetic factor determines HIV/AIDS risk

Ascorbic acid doesn't seem to help physical exercise performance

Discovery could lead to a screening test that identifies people who have a higher or lower susceptibility to HIV/AIDS

Processes shed light on how DNA recombination mechanisms are related

Direct modulation of progesterone signaling appears to influence ovarian cancer risk

Signaling molecule involved in osteoarthritis identified

Exposure to the chemical BPA (Bisphenol A) stimulates prostate cancer cell growth

Study shows women with invasive lobular carcinoma may not need chemotherapy before surgery

Ubiquitination protects against improper Notch signaling

New findings clarify the role of NOD2, a key molecular player in Crohn's Disease

FDA approves Enablex for the treatment of overactive bladder

Theory that could help to cure diseases including cancer

Stem cells use inflammatory signals to find injured tissue

Detrol LA significantly reduces symptoms of overactive bladder

New approach to genomic testing identifies women with low risk of breast cancer recurrence

Women over the age of 60 with low-risk breast cancer may not need to receive radiation therapy after surgery

Findings could lead to new knowledge that could speed the development of drugs to block botulism or tetanus toxins more rapidly

Study of early stage breast cancer patients identifies women at low risk of breast cancer mortality

Using precise, radioactively labeled genetic probes, researchers study cancer gene activity from outside the body

Celecoxib may regulate a cell's use of estrogen - might help explain the drug's anticancer properties

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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