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SITESEEKER to be used for Otsuka’s therapeutics discovery programs

PhoreMost will deploy its in-house expertise and next-generation phenotypic screening platform, SITESEEKER, in disease-relevant pathways nominated by Otsuka.

From PhoreMost 21 Jan 2020

Certain enzymes implicated in diseases like cancer also destroy each other

Like motley bandits, certain enzymes implicated in cancer and other diseases also annihilate each other. A new study reveals details of their mutual foils in the hopes that these behaviors can be leveraged to fight the enzymes' disease potential.

20 Jan 2020

Study uncovers anticancer potential of many non-oncology drugs

Drugs for diabetes, inflammation, alcoholism -- and even for treating arthritis in dogs -- can also kill cancer cells in the lab, according to a study by scientists at the Broad Institute of MIT and Harvard and Dana-Farber Cancer Institute.

20 Jan 2020

Enzymes that cannibalize each other and promote cancer

A new study to be published this week in the journal The Proceedings of the National Academy of Sciences in the week of January 20, 2020. shows that certain human enzymes play dual roles in health and disease. Not only do they promote the occurrence of cancer and some other illnesses, they also eliminate one another rather like cannibals. The researchers hope this behaviour can be exploited to prevent these enzymes from causing human disease.

20 Jan 2020

New uses for old medicines

It turns out that in the rush to invent new drugs to treat cancers, scientists may have overlooked some obvious possibilities of existing drugs currently being used for other diseases. A new study says that therapies for diabetes, inflammation and alcoholism, and even for dog arthritis, can also result in the successful killing of cancer cells in culture.

20 Jan 2020

Refining pathological classification of breast cancer using multiplexed imaging

Breast cancer progression can vary significantly between patients. Even within the same tumor, different areas may be composed of different types of cells and characterized by different tumor structures.

20 Jan 2020

UCR receives $2.2 million grant to target critical oncogenes of B-cell lymphoma 2

One way to tackle cancer, the second-leading cause of death in the United States, is to target oncogenes -- genes that have the potential to cause cancer.

17 Jan 2020

Researchers visualize molecular organization of TNFα receptor molecules

Whether a sick cell dies, divides, or travels through the body is regulated by a sophisticat-ed interplay of signal molecules and receptors on the cell membrane.

17 Jan 2020

Finding has major ramifications for ongoing drug development against MLL-rearranged leukemia

A massive research effort over more than a quarter century has tried to make personalized blood stem cells for use in treating leukemias, among many other uses.

17 Jan 2020

Discovery on heart cell research may lead to inaccurate data

Researchers studying proteins in heart cells have unexpectedly discovered that a common microscopy fluorescent protein carries reversible photobleaching properties. This phenomenon may lead to inaccurate or unreliable data.

17 Jan 2020

UT Southwestern study identifies new vulnerability in kidney tumors

A UT Southwestern researcher led a team that identified a new vulnerability in kidney tumors, the 10th most common cause of cancer death in men and women.

17 Jan 2020

Discovery of mechanism by which Zika virus enters brain cells

Two independent studies published by Cell Press on January 16, 2020, report that the mechanism by which Zika virus enters brain cells has been identified and even more, exploited to prevent Zika infection and to kill cancer cells instead.

16 Jan 2020

"Jumping genes" within eggs determine their survival

Females are born with a finite supply of eggs and with age the genetic quality of the eggs decline say researchers from Carnegie Institute. The study from researchers Marla Tharp, Safia Malki, and Alex Bortvin was published in the latest issue of Nature Communications. The study was titled, “Maximizing the ovarian reserve in mice by evading LINE-1 genotoxicity.”

16 Jan 2020

Study provides new insights into small acidic protein linked to Parkinson's disease

Research by University at Buffalo biologists is providing new insights into alpha-synuclein, a small acidic protein associated with Parkinson's disease.

16 Jan 2020

'Pulling the plug' on calcium pumps to kill pancreatic cancer cells

UK scientists have identified a new way to kill pancreatic cancer cells by 'pulling the plug' on the energy generator that fuels calcium pumps on their cell surface.

16 Jan 2020

Cell adhesion essential for cells to survive stress

Cell-to-cell contacts are necessary for the survival of human cells under protein-damaging conditions and stress.

16 Jan 2020

Research shows how the body tries to eliminate egg cells of poorest quality

A woman's supply of eggs is finite, so it is crucial that the quality of their genetic material is ensured. New work from Carnegie's Marla Tharp, Safia Malki, and Alex Bortvin elucidates a mechanism by which, even before birth, the body tries to eliminate egg cells of the poorest quality.

16 Jan 2020