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Researchers uncover molecular link between trans fats and variety of disorders

Tohoku University researchers in Japan have uncovered a molecular link between some trans fats and a variety of disorders, including cardiovascular and neurodegenerative diseases.

25 Mar 2020

YAP signal pathway plays a vital role in the onset of head-and-neck cancer

Joint research between Kobe University and National Hospital Organization Kyushu Cancer Center has revealed that mice with mutations in the YAP signal pathway develop head-and-neck cancer over an extremely short period of time (world's fastest cancer onset mouse model), indicating that this pathway plays a crucial role in the onset of these cancers.

25 Mar 2020

Discovery shows a novel opportunity for DOT1L inhibitors in cancer treatment

Oncotarget Volume 11, Issue 11 reported that in order to understand the molecular mechanism of the dependency in MM, the research team examined gene expression changes upon DOT1L inhibition in sensitive and insensitive cell lines and discovered that genes belonging to the endoplasmic reticulum stress pathway and protein synthesis machinery were specifically suppressed in sensitive cells.

22 Mar 2020

Antibiotic blocks the integration of building blocks into the cell wall of pathogens

One of the last arrows in the quiver in the fight against dangerous bacteria is the reserve antibiotic daptomycin.

21 Mar 2020

Revolutionary technology could help identify more effective cancer drug combinations

A revolutionary new technology has been applied to reveal the inner workings of individual cancer cells - potentially identifying more effective treatment combinations for people with cancer.

19 Mar 2020

Viewpoint: Could infectious pathogens play a role in Alzheimer's disease?

For researchers investigating Alzheimer's Disease (AD), a devastating neurodegenerative illness afflicting close to 6 million Americans, it is the best and worst of times.

18 Mar 2020

Immune mechanism in the brain appears to play key role in the development of Alzheimer's

An immune reaction in the brain seems to play a major role in the development of Alzheimer's disease. In a way, it "adds fuel to the fire" and apparently causes an inflammation that, in a sense, keeps kindling itself. The study has now been published in the journal Cell Reports.

18 Mar 2020

MCL1 protein essential in protecting the intestine against cancer development

An international team of researchers from the University of Zurich, the University Hospital Zurich, Heidelberg and Glasgow has identified a novel function for the cell death regulating protein MCL1: It is essential in protecting the intestine against cancer development – independent of bacterial-driven inflammation.

18 Mar 2020

Damaging the tumor blood vessels could be new strategy to treat oral cancer

Researchers at Okayama University have recently published a study in Cells in which they reduced the size of oral cancer tumors by damaging the blood vessels surrounding the tumor cells.

17 Mar 2020

Changes in cellular degradation hubs can lead to cancer

A team of scientists at Uppsala University has revealed that alterations in cells’ lysosomes underly abnormal cell growth.

17 Mar 2020

Uncovering the Achilles' heel of cancer cells to find effective cures

The key to effective cures for cancers is to find weak points of cancer cells that are not found in non-cancer cells.

17 Mar 2020

Trial of cancer drug OxaliTex promises lower toxicity and more robust action

Preclinical trials indicate that a drug candidate called OxaliTex can stop the growth of cancer cells completely. OxaliTex appears to be more potent than many other common chemotherapy drugs, with less toxicity and less rapidly counteracted by mechanisms of drug resistance. The study was reported in the journal Proceedings of the National Academy of Sciences in March 2020.

16 Mar 2020

Scientists discover link between Parkinson's and gene targeted by blue-green algae toxin

Scientists have discovered a possible link between Parkinson's disease and a gene impacted by a neurotoxin found in blue-green algae.

16 Mar 2020

Tooth-enamel protein discovered in the eyes of people with dry AMD

A protein that normally deposits mineralized calcium in tooth enamel may also be responsible for calcium deposits in the back of the eye in people with dry age-related macular degeneration, according to a study from researchers at the National Eye Institute.

13 Mar 2020

Single-drug therapy can attack several cellular targets using different modes of action

Clinicians combat the drug resistances of some cancer types by using a combination of different drugs. To make this approach more effective, chemists have designed a chemical conjugate that can simultaneously attack several cellular targets using different modes of action.

13 Mar 2020

Researchers uncover clues to how statins kill cancer cells

More than 35 million Americans take statin drugs daily to lower their blood cholesterol levels. Now, in experiments with human cells in the laboratory, researchers at Johns Hopkins Medicine have added to growing evidence that the ubiquitous drug may kill cancer cells and have uncovered clues to how they do it.

12 Mar 2020

Potential breakthrough in cancer immunotherapy with gasdermin E

A new study published in the journal Nature in March 2020 reports the discovery of a new approach to cancer immunotherapy, which could be useful in many more cancers than at present.

11 Mar 2020

Diet influences multiple sclerosis disease course

The short-chain fatty acid propionic acid influences the intestine-mediated immune regulation in people with multiple sclerosis (MS).

11 Mar 2020

Exploring the biological link between reactivated HSV and neurological disease

Without even knowing it, most of us carry around latent Herpes Simplex Virus in our nervous system- a simple result of being born and living together with others carrying the virus.

10 Mar 2020

Levels of sBTLA proteins may be a marker of overall survival in patients with HCC

In the 2020 February 25 issue of Scientific Reports, a research group from the Department of Hepatology in Osaka City University Graduate School of Medicine, Japan reported that levels of a circulating soluble immune checkpoint protein can be used as a potential marker to predict overall survival in patients with advanced HCC.

9 Mar 2020