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Minicells play key function in self-preservation of bacteria, finds study

Scientists have known for decades that certain bacteria produce small spherical versions of themselves. Although they lack basic materials to reproduce or function like normal cells, recent interest in such "minicells" has spiked due to their proficiency as nano-sized delivery tools for drugs and vaccines to targeted cells and tissues.

27 Sep 2018

New book provides evidence that new drugs, medical technologies are safe and effective

Does a new medicine or diagnostic test work? Is it safe? Should the government approve it and insurers pay for it? The answers are not as straightforward as they may seem - and the reasons are the subject of a new book by Karen J. Maschke, a research scholar at The Hastings Center, and Michael K. Gusmano, a Hastings Center research scholar and an associate professor of health policy at Rutgers University School of Public Health.

27 Sep 2018

Antibiotic resistance in cystic fibrosis linked to decreased microbial diversity and pulmonary function

A defective gene causes thick, sticky mucus to build up in the lungs of patients with cystic fibrosis. There, it traps bacteria, causing patients to develop frequent lung infections that progressively damage these vital organs and impair patients' ability to breathe.

27 Sep 2018

New drug to treat Parkinson's disease psychosis do not pose greater risk of death

In the wake of media and public reports about increased mortality linked to a new drug for treating Parkinson's disease psychosis -- a symptom of the progressive nervous system disorder in which patients experience hallucinations and delusions -- researchers at University of California San Diego School of Medicine conducted a retrospective study of qualifying patients in the UC San Diego Health system, concluding that the new drug, pimavanserin, did not pose a statistically significant greater risk of death.

27 Sep 2018

UH pharmacologist receives NIH grant to improve kidney function in older people

Mohammad Asghar, associate professor of pharmacology at the University of Houston, has been awarded $459,000 from the National Institutes of Health/National Institute on Aging to improve kidney function in people 65 and older, a population at higher risk for developing impaired kidney function.

27 Sep 2018

NIAID releases strategic plan to expand knowledge of TB by using modern tools

Tuberculosis (TB) is the leading infectious cause of death worldwide, killing roughly 1.6 million people in 2017. In the past 200 years, TB claimed the lives of more than one billion people--more deaths than from malaria, influenza, smallpox, HIV/AIDS, cholera and plague combined.

27 Sep 2018

Scientists develop new protocol for measuring background levels of drugs in forensic labs

When crime lab chemists handle evidence that contains illegal drugs, trace amounts of those drugs are inevitably released into the laboratory environment.

27 Sep 2018

New compound promotes social interaction in laboratory mice with autism

Children with autism often find social interactions awkward, leaving them isolated. Now in a study appearing in ACS' Journal of Medicinal Chemistry, scientists report that they have discovered a first-of-its-kind compound that promotes social interaction among laboratory mice that display autistic traits.

26 Sep 2018

Researchers take first steps in developing 'paintable' chemotherapy for melanoma

Skin acts as the first line of defense against pathogens and other harmful material from outside the body. Yet this barrier also excludes some beneficial drugs that could treat skin diseases.

26 Sep 2018

University of Birmingham receives £1.9 million for global heart research in China, Brazil and Sri Lanka

The University of Birmingham has been awarded £1.9 million through the National Institute for Health Research Global Health Research Program to fund world class research into a common heart condition in disadvantaged populations in China, Brazil and Sri Lanka.

26 Sep 2018

Recategorization recommendations for drug in hallucinogenic mushrooms

In an evaluation of the safety and abuse research on the drug in hallucinogenic mushrooms, Johns Hopkins researchers suggest that if it clears phase III clinical trials, psilocybin should be re-categorized from a schedule I drug--one with no known medical potential--to a schedule IV drug such as prescription sleep aids, but with tighter control.

26 Sep 2018

Urine liquid biopsies could help monitor response to immunotherapy in bladder cancer patients

Scientists have shown for the first time that immune cells in the urine of bladder cancer patients accurately reflect those in the tumor environment, according to research published today (Wednesday) in the Journal of Experimental Medicine.

26 Sep 2018

New inflammatory biomarker correlates with increased thrombosis risk in cancer patients

Cancer patients are known to have an increased risk of thrombosis. As part of the CATS study, MedUni Vienna researchers have now investigated a correlation between an activated immune system in cancer patients and their risk of thrombosis.

26 Sep 2018

Urine exRNA may be source of biomarkers for muscular dystrophy

Massachusetts General Hospital researchers have found that extracellular RNA in urine may be a source of biomarkers for the two most common forms of muscular dystrophy, noninvasively providing information about whether therapeutic drugs are having the desired effects on a molecular level.

26 Sep 2018

Brigatinib drug may offer first-line treatment option for ALK-positive NSCLC

Results of a 275-patient, multi-national phase III clinical trial known as ALTA-1L published today in the New England Journal of Medicine and presented concurrently in the press program at the International Association for the Study of Lung Cancer (IASLC) World Conference on Lung Cancer 2018 argue for brigatinib as a first-line treatment option for advanced ALK-positive non-small cell lung cancer.

26 Sep 2018

Alzheimer’s disease researchers makes significant breakthroughs

Researchers in Sweden and United Kingdom have made a breakthrough in Alzheimer’s disease research. They could soon be on the path to develop new drugs that could fight the disease more effectively.

26 Sep 2018

Novel drug alleviates memory deficits and neuropathology in Alzheimer's animal model

New research conducted at the Lady Davis Institute at the Jewish General Hospital reveals that a novel drug reverses memory deficits and stops Alzheimer disease pathology in an animal model.

25 Sep 2018

Study reveals structure of potential drug target in neurological conditions

Researchers at Van Andel Research Institute (VARI) have revealed the atomic-level structure of a protein that could serve as a promising new drug target for the treatment of neurological conditions such as bipolar disorder and Alzheimer’s disease.

25 Sep 2018

Increased physical activity associated with improvement in IBS symptoms

Increased physical activity is now being emphasized as a treatment option for the gastric intestinal disease known as IBS. Research at Sahlgrenska Academy, Sweden, indicates improvements in both intestinal function and self-esteem of patients who exercise more.

25 Sep 2018

FDA grants Orphan Drug Designation to Myelo001 for treatment of Acute Radiation Syndrome

Myelo Therapeutics GmbH announced today that the US Food and Drug Administration has granted an Orphan Drug Designation to its orally applied new chemical entity Myelo001 for the treatment of Acute Radiation Syndrome.

25 Sep 2018

Drugs News and Research

Minicells play key function in self-preservation of bacteria, finds study

New book provides evidence that new drugs, medical technologies are safe and effective

Antibiotic resistance in cystic fibrosis linked to decreased microbial diversity and pulmonary function

New drug to treat Parkinson's disease psychosis do not pose greater risk of death

UH pharmacologist receives NIH grant to improve kidney function in older people

NIAID releases strategic plan to expand knowledge of TB by using modern tools

Scientists develop new protocol for measuring background levels of drugs in forensic labs

New compound promotes social interaction in laboratory mice with autism

Researchers take first steps in developing 'paintable' chemotherapy for melanoma

University of Birmingham receives £1.9 million for global heart research in China, Brazil and Sri Lanka

Recategorization recommendations for drug in hallucinogenic mushrooms

Urine liquid biopsies could help monitor response to immunotherapy in bladder cancer patients

New inflammatory biomarker correlates with increased thrombosis risk in cancer patients

Urine exRNA may be source of biomarkers for muscular dystrophy

Brigatinib drug may offer first-line treatment option for ALK-positive NSCLC

Alzheimer’s disease researchers makes significant breakthroughs

Novel drug alleviates memory deficits and neuropathology in Alzheimer's animal model

Study reveals structure of potential drug target in neurological conditions

Increased physical activity associated with improvement in IBS symptoms

FDA grants Orphan Drug Designation to Myelo001 for treatment of Acute Radiation Syndrome

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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