Neurodegenerative Diseases News and Research

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Findings offer novel way for creating drugs to stop mitochondria from destroying cells during stress

Malfunctioning mitochondria — the power plants in cells — are behind the damage caused by strokes, heart attacks, and neurodegenerative diseases, but little has been known about how to stop these reactors from melting down, destroying cells and tissue. Mitochondria also take up calcium, which regulates energy production.

11 Mar 2016

TSRI researchers uncover new molecular mechanism underlying neurodegenerative diseases

A new study led by scientists at The Scripps Research Institute suggests that cells construct protein "clumps" to protect against neurodegenerative diseases such as amyotrophic lateral sclerosis, a.k.a. ALS or Lou Gehrig's disease.

10 Mar 2016

Novel mechanism identified to protect the brain from many neurodegenerative conditions

Scientists at Case Western Reserve University School of Medicine have identified a novel mechanism that could be used to protect the brain from damage due to stroke and a variety of neurodegenerative conditions, including sporadic Creutzfeldt-Jakob disease, Alzheimer's disease, and Parkinson's disease.

8 Mar 2016

Research highlights association of western diet with Alzheimer's disease

Recent research has established associations between certain environmental factors, including eating a western diet and being sedentary, with an increased susceptibility to Alzheimer's disease. In fact, it is estimated that a combination of diet and inactivity contributes to as many as 25% of Alzheimer's cases. Nonetheless, little is known about the exact disease mechanisms and how or why this increasingly common middle-age lifestyle can play such a big role in subsequent cognitive function.

7 Mar 2016

Preliminary results of blood test to diagnose CTE during life published in Journal of Alzheimer's Disease

Exosome Sciences, Inc., in collaboration with majority shareholder Aethlon Medical, Inc. and investigators at Boston University and the University of Washington, announced today the published preliminary results of possibly the first blood test to detect the neurodegenerative disease, Chronic Traumatic Encephalopathy (CTE) during life.

7 Mar 2016

Drinking more coffee may reduce risk of multiple sclerosis

Drinking a lot of coffee every day--more than 900 ml (30 fluid ounces) or around six cups--is linked to a reduced risk of multiple sclerosis (MS), finds research published online in the Journal of Neurology Neurosurgery & Psychiatry.

7 Mar 2016

Long-term exercise may benefit Spinal Muscular Atrophy patients

Long-term exercise appears to be beneficial for Spinal Muscular Atrophy (SMA) like mice, suggesting a potential of active physiotherapy for patient care; according to a study published today in the Journal of Physiology.

6 Mar 2016

Study identifies biomarker that plays role in early stages of Alzheimer's disease

A multicenter study led by Christian Haass and Michael Ewers of Ludwig-Maximilians-Universitaet in Munich has identified a biomarker associated with the activation of an innate immune response to neural damage during early stages of Alzheimer's disease.

4 Mar 2016

Polyunsaturated lipids can alter binding rate of two receptors involved in Parkinson's and Alzheimer's

A study published in the prestigious journal Scientific Reports from the Nature group demonstrates, for the first time and using computational tools, that polyunsaturated lipids can alter the binding rate of two types of receivers involved in certain nervous system diseases.

2 Mar 2016

Novel therapeutic approach to target monomeric Tau protein

Dementia and other tauopathies, most notably Alzheimer's disease, embody a class of neurodegenerative diseases associated with the aggregation of the Tau protein in the human brain. These diseases represent one of the leading causes of death and disability in the elderly population in the western world, with no current effective therapy.

27 Feb 2016

Study: Magnesium therapy can alleviate muscular symptoms in patients with Motor Neurone Disease

Around 5,000 Motor Neurone Disease (MND) sufferers across the UK could find relief to their muscular symptoms thanks to transdermal (through the skin) magnesium therapy, say health pioneers BetterYou.

From BetterYou Ltd 25 Feb 2016

UEA research paves way for new wave of drugs to kill superbugs

Scientists at the University of East Anglia are getting closer to solving the problem of antibiotic resistance.

24 Feb 2016

Researchers identify common molecular alteration in glioblastoma

Glioblastoma is the most aggressive manifestation of brain tumours. Due to its high invasive capacity and uncontrolled, infiltrating growth, it is particularly difficult to manage. Currently, the treatment for this disease consists of a combination of surgery (when possible), radiation and chemotherapy.

22 Feb 2016

Small peptide TAxI holds promise for carrying biologic drugs into spinal cord

A small peptide dubbed TAxI is living up to its name. Recent studies show it to be an effective vehicle for shuttling functional proteins, such as active enzymes, into the spinal cord after a muscle injection.

17 Feb 2016

Innovative tool helps observe protein aggregates linked to neurodegenerative diseases

For rent: 32 individual rooms for a combined surface area of 4cm2, heating and food included! Biologists and microfluidics specialists at EPFL have joined forces and developed a highly innovative research tool: a 2cm by 2cm 'chip' with 32 independent compartments, each of which is designed to hold a nematode - a widely used worm in the research world. The device is described in the journal Molecular Neurodegeneration.

16 Feb 2016

Unlocking intrinsically disordered proteins: an interview with Peter Wright

I'm a professor in the Department of Integrative Structural and Computational Biology at The Scripps Research Institute. I have been performing NMR research on proteins for nearly 40 years.

From Bruker BioSpin - NMR, EPR and Imaging 11 Feb 2016

Lamin nucleoskeleton disordered in Alzheimer's

Brain cell death in Alzheimer's disease is linked to disruption of a skeleton that surrounds the nucleus of the cells, a researcher in the School of Medicine at The University of Texas Health Science Center at San Antonio said.

5 Feb 2016

Study finding could shed light on molecular mechanisms underlying Huntington's disease

Researchers at the University of Pittsburgh School of Medicine have shown that the core of the protein clumps found in the brains of people with Huntington's disease have a distinctive structure, a finding that could shed light on the molecular mechanisms underlying the neurodegenerative disorder.

4 Feb 2016

Stopping disruptions in cellular 'trash removal' may guard against neurodegenerative diseases

Stopping disruptions in cellular "trash removal" brought on by errors in molecular marks on DNA may guard against neurodegenerative diseases like Parkinson's.

27 Jan 2016

Chronic exposure to environmental toxin may up risk of neurodegenerative illness

A new study published today in the science journal Proceedings of the Royal Society B indicates that chronic exposure to an environmental toxin may increase risk of neurodegenerative illness. Conducted by scientists at the Institute for EthnoMedicine, a non-profit medical research organization, and the University of Miami Brain Endowment Bank, the study provides a foundation for future research in Alzheimer's disease, ALS and Parkinson's disease.

25 Jan 2016

Neurodegenerative Diseases News and Research

Findings offer novel way for creating drugs to stop mitochondria from destroying cells during stress

TSRI researchers uncover new molecular mechanism underlying neurodegenerative diseases

Novel mechanism identified to protect the brain from many neurodegenerative conditions

Research highlights association of western diet with Alzheimer's disease

Preliminary results of blood test to diagnose CTE during life published in Journal of Alzheimer's Disease

Drinking more coffee may reduce risk of multiple sclerosis

Long-term exercise may benefit Spinal Muscular Atrophy patients

Study identifies biomarker that plays role in early stages of Alzheimer's disease

Polyunsaturated lipids can alter binding rate of two receptors involved in Parkinson's and Alzheimer's

Novel therapeutic approach to target monomeric Tau protein

Study: Magnesium therapy can alleviate muscular symptoms in patients with Motor Neurone Disease

UEA research paves way for new wave of drugs to kill superbugs

Researchers identify common molecular alteration in glioblastoma

Small peptide TAxI holds promise for carrying biologic drugs into spinal cord

Innovative tool helps observe protein aggregates linked to neurodegenerative diseases

Unlocking intrinsically disordered proteins: an interview with Peter Wright

Lamin nucleoskeleton disordered in Alzheimer's

Study finding could shed light on molecular mechanisms underlying Huntington's disease

Stopping disruptions in cellular 'trash removal' may guard against neurodegenerative diseases

Chronic exposure to environmental toxin may up risk of neurodegenerative illness

Discover how SciY empowers scientists

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

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