Adenosine News and Research

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Adenosine is a nucleoside composed of a molecule of adenine attached to a ribose sugar molecule (ribofuranose) moiety via a ß-N9-glycosidic bond.

Study identifies shared pathway driving cardiac fibrosis

Three adenosine receptor subtypes that normally send different signals were found to converge on a common pathway that activates cardiac fibroblasts, the scar-forming cells in the heart.

24 Sep 2026

Beetroot juice may make swimming feel easier without making swimmers faster

A systematic review and meta-analysis of 12 studies, with nine contributing data from 120 swimmers, found no significant improvement in swimming time-trial performance or post-exercise blood lactate with beetroot juice or dietary nitrate supplementation. Supplementation produced a small reduction in perceived exertion, but the effect varied across studies, and the certainty of evidence for swimming performance was low.

24 Sep 2026

KAIST team uncovers how neurons deliver RNA to distant regions

Much like a courier reading an address on a package, neurons must deliver RNA to the precise locations where it is needed.

15 Sep 2026

Early studies hint that ketones may affect pathways linked to PTSD

An integrative review found that ketogenic therapy may influence metabolic, inflammatory, oxidative stress, and neurotransmitter pathways implicated in PTSD, with animal studies and small human studies reporting early signs of symptom improvement. Human evidence remains limited to very small cohorts, case reports, and pilot studies, and controlled trials have yet to establish clinical efficacy.

11 Sep 2026

Psilocybin protects sensory nerves from chemotherapy damage in preclinical study

In mouse models, prophylactic psilocybin prevented or reduced multiple features of chemotherapy-induced peripheral neuropathy, with cycle-matched dosing sustaining protection during repeated cisplatin exposure without measurably affecting tumor growth. Experiments in human-derived sensory neurons and ex vivo peripheral nerves linked the effect to 5-HT2A-dependent preservation of mitochondrial trafficking and local axonal energy supply, while a nonhallucinogenic 5-HT2A agonist reproduced protection against mechanical hypersensitivity.

6 Sep 2026

Coffee, tea and dementia risk: Why the amount you drink could matter

A targeted perspective synthesizes epidemiological and mechanistic evidence examining how caffeine consumption during midlife may influence dementia risk later in life. The authors highlight potential roles for dose, age, CYP1A2 genotype, adenosine signaling and cultural drinking practices, while stressing that current observational evidence cannot establish causality.

3 Sep 2026

Modified AlphaFold3 successfully predicts complex protein conformational changes

Conformational changes in proteins are vital to their function yet remain challenging for state-of-the-art artificial intelligence, such as AlphaFold3, to predict.

1 Sep 2026

Can caffeine make you mentally sharper in the morning? This study tested the idea

In a controlled crossover study of 51 recreationally active young men with low habitual caffeine intake, researchers tested whether 300 mg of caffeine taken about an hour before morning testing affected cognition, mood, temperature, appetite, and related outcomes, with reactive agility assessed in 27 participants. Caffeine did not improve cognitive or reactive agility performance or meaningfully alter mood, tiredness, appetite, or thermoregulation under the study conditions.

27 Aug 2026

Mitochondrial transplantation helps repair donor organs during machine perfusion

Transplant medicine still depends on a limited supply of donor organs, while many retrieved grafts are discarded because ischemia, cold storage, and reperfusion can rapidly damage their cells.

25 Aug 2026

Researchers combine two nanomachines to build lifelike DNA networks

Drawing inspiration from the dynamic architecture of living systems, researchers from Institute of Science Tokyo and Kyoto University have harnessed two chemically fueled biomolecular nanomachines, DNA polymerase and kinesin, to synthesize and actively assemble complex, hierarchical DNA networks.

19 Aug 2026

Mitochondrial rewiring may explain why orthoflaviviruses harm humans but persist in mosquitoes

Orthoflaviviruses reshape mitochondrial structure, metabolism, redox signaling, and quality control differently across human and mosquito models, helping explain their contrasting infection outcomes. The review highlights mitochondrial pathways that may support acute cellular damage in vertebrates but persistent, non-lethal infection in mosquitoes, pointing to potential antiviral targets.

12 Aug 2026

The coffee advice given to atrial fibrillation patients may deserve a rethink

The DECAF randomized trial found that adults with persistent atrial fibrillation or atrial flutter assigned to drink at least one cup of caffeinated coffee daily had a 39% lower hazard of recurrent clinically detected AF or flutter than those assigned to avoid coffee and caffeine. The findings challenge longstanding advice to routinely restrict caffeinated coffee in people with AF, while further research is needed to determine whether coffee itself provides a protective effect.

12 Aug 2026

New review explores purinergic signaling pathways in osteoarthritis progression

A growing understanding of purinergic signaling is reshaping how scientists view osteoarthritis (OA), revealing an intricate communication network that influences joint inflammation, cartilage degeneration, bone remodeling, and chronic pain.

7 Aug 2026

Perilla oil may curb platelet reactivity and inflammatory signaling in smokers

An eight-week randomized trial found that daily perilla oil increased plasma and red-cell ALA, plasma EPA, and platelet closure time in healthy smokers. Perilla oil also reduced TNF-α and TBX21 gene expression, but it did not improve broader coagulation, lipid, endothelial, or postprandial markers.

3 Aug 2026

New mechanism linked to septic heart injury protection uncovered

Sepsis triggers widespread inflammation, circulatory failure and metabolic stress, and cardiac dysfunction is a common complication associated with sharply poorer outcomes.

31 Jul 2026

Some caffeinated drinks are linked to poorer memory

A study on caffeine's impact reveals product-specific effects on anxiety, memory, and stress among university students, highlighting mental health implications.

28 Jul 2026

A common dietary nutrient feeds a gut pathway linked to atrial fibrillation

Researchers linked higher plasma TMAO to prevalent atrial fibrillation in 5,090 people and found that TMAO or choline supplementation accelerated AF onset, progression, atrial remodeling, and electrical dysfunction in mice. Inhibiting gut microbial TMA production lowered circulating TMAO and delayed AF in mice, identifying a potential therapeutic pathway that now requires human testing.

27 Jul 2026

MEK inhibition could limit T cell exhaustion and give a boost to immunotherapy

A major pillar of cancer immunotherapy involves stimulating T cells, the specialized killers of the immune system, to attack tumors.

23 Jul 2026

Spermidine boosts key cellular processes linked to aging in early research

This review finds that spermidine supports autophagy, mitochondrial function, and healthspan in experimental models, while observational studies link higher dietary intake to lower mortality. However, human trials have produced limited and mixed results, leaving its clinical role in healthy aging unresolved.

23 Jul 2026

Moderate coffee intake may support heart health, AHA says

The American Heart Association finds that habitual coffee consumption is associated with lower risks of several cardiovascular outcomes, although most evidence comes from observational studies. Moderate intake is generally safe for most adults, while energy drinks and individual caffeine sensitivity may increase cardiovascular concerns.

21 Jul 2026