Anaphylaxis News and Research

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Anaphylaxis is an acute multi-system severe type I hypersensitivity reaction. Due in part to the variety of definitions, between 1% and 15% of the population of the United States can be considered "at risk" for having an anaphylactic reaction if they are exposed to one or more allergens. Of those people who actually experience anaphylaxis, up to 1% may die as a result.

Can maternal diet prevent infant food allergy? A large trial puts eggs and peanuts to the test

A large Australian randomized trial of 2,137 pregnant women tested whether substantially increasing egg and peanut consumption during pregnancy and breastfeeding could prevent food allergy in infants with a strong family history of allergic disease. Higher maternal intake did not significantly reduce IgE-mediated egg or peanut allergy at 1 year, although the lower-than-expected allergy rate limited statistical power and the results could not exclude a clinically important benefit.

17 Sep 2026

Orexo announces FDA acceptance of Investigational New Drug (IND) application for OX640 for the treatment of anaphylaxis

Orexo AB (publ.) today announces that the U.S. Food and Drug Administration (FDA) has accepted its Investigational New Drug (IND) application for OX640, a nasally administered powder formulation of epinephrine intended for the emergency treatment of anaphylaxis.

15 Sep 2026

Martha's Vineyard Hospital launches study to better understand alpha-gal syndrome

Martha's Vineyard Hospital, a member of Mass General Brigham, has begun recruiting participants for a research study designed to better understand alpha-gal syndrome (AGS), a potentially serious allergic condition associated with lone star tick exposure.

25 Aug 2026

Tick-borne alpha-gal syndrome poses potential risks during blood transfusions

A new multi-institute study led by researchers at Dartmouth Health and Geisel School of Medicine at Dartmouth suggests that alpha-gal syndrome, the tick-borne disease that can result in a chronic allergy to meat and animal byproducts, also may complicate certain patients' ability to safely receive a blood plasma or platelet transfusion.

24 Aug 2026

Researchers uncover mechanism linking skin inflammation to body-wide allergies

Our bodies experience allergic reactions when the immune system mistakenly overreacts to harmless substances, known as allergens, such as pollen, dust, or certain foods.

6 Aug 2026

Microbiome-based therapy may increase peanut allergy tolerance in adults

Some 33 million Americans have severe food allergies. Now, researchers at Boston Children's Hospital may have found a promising solution.

5 Aug 2026

Mouse study links leaky gut to severe food allergies

A "leaky gut" might increase the severity of food allergies, according to new research conducted in mice and published in The Journal of Immunology.

31 Jul 2026

Omalizumab beats multiallergen oral immunotherapy in multifood allergy trial

Omalizumab demonstrates higher treatment success for multifood allergies compared to oral immunotherapy, with fewer adverse events impacting patient retention.

30 Jul 2026

Review highlights strong safety and effectiveness of mRNA vaccines

A comprehensive new review published in The Lancet affirms that currently approved mRNA vaccines are safe and highly effective at preventing infectious diseases, including COVID-19.

30 Jun 2026

Review explores diagnosis and management of perioperative anaphylaxis during anesthesia

Perioperative anaphylaxis is a rare, life‑threatening condition during anesthesia. The unique setting – multiple drugs, patient draping, and altered physiology – causes higher mortality than anaphylaxis elsewhere.

29 May 2026

Slow and steady wins: Low-dose peanut immunotherapy safely desensitizes 82% of preschoolers in landmark trial

A Swedish randomized trial found that slow up-dosing peanut oral immunotherapy with a low maintenance dose helped 82% of preschool children achieve sustained peanut tolerance after three years. The approach proved safer than conventional protocols, with severe reactions uncommon and strong family adherence throughout treatment.

10 May 2026

Delayed adrenaline use linked to fatal childhood food anaphylaxis

Fatal delays in administering life-saving adrenaline autoinjector (EpiPen) for food anaphylaxis, a severe and rapid allergic reaction, is highlighted in research being presented at the Royal College of Emergency Medicine Conference today [28 April].

27 Apr 2026

When rice-based formula is the right choice for cow’s milk allergy

This expert-driven framework aids clinicians in selecting hydrolyzed rice formula for infants with cow's milk allergy, enhancing dietary management strategies.

17 Apr 2026

High affinity for immune receptors predicts antibody drug associated anaphylaxis risk

Antibody therapeutics are laboratory-made proteins designed to work like the body's natural antibodies. They are widely used to treat diseases such as cancer by binding to specific targets, including cancer cells or inflammatory molecules.

8 Apr 2026

Gut bacteria may explain differences in peanut allergy reactions

One of the big mysteries in food allergy is why two people with similar levels of peanut specific antibodies can react so differently. It turns out the answer may be in the mouth and gut's bacteria.

3 Mar 2026

Top early-life factors driving childhood food allergy

This study analyzes 190 research papers to uncover early-life predictors of food allergies in children, highlighting skin barrier health and family history.

12 Feb 2026

Targeted Fab fragments dismantle the allergy trigger

Allergic diseases represent a major global health burden, placing significant strain on healthcare systems worldwide. Severe conditions such as anaphylaxis, asthma, food allergy, and allergic rhinitis are driven by immunoglobulin E (IgE), an antibody that binds to immune cells, including mast cells and basophils.

27 Jan 2026

Reduced peanut OIT dose offers safer, accessible treatment for children

Children with peanut allergies may not need large doses of peanut oral immunotherapy (OIT) to build protection to peanut, finds a new study led by The Hospital for Sick Children (SickKids) and Montreal Children's Hospital. Researchers found that a small dose can help children with their peanut allergy and reduce the risk of severe reactions from accidental exposures, with less side effects than the current standard treatment.

30 Dec 2025

Unnecessary gluten-free diets may put children at risk

Understanding gluten-related disorders is crucial for pediatric nutrition, as gluten-free diets can pose health risks without appropriate medical supervision.

15 Dec 2025

Researchers confirm first death linked to tick-induced meat allergy

University of Virginia School of Medicine researchers have identified the first death caused by what is commonly called the "meat allergy" being spread by ticks.

13 Nov 2025