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Gut microbiome clues may help spot Parkinson’s disease in its earliest phase

Researchers found that a Parkinson’s disease-related gut microbiome pattern appears not only in people with diagnosed Parkinson’s, but also in some non-manifesting GBA1 variant carriers and a subset of healthy individuals. The findings suggest that gut microbiome changes may help flag people who are closer to Parkinson’s disease development, although longitudinal studies are still needed to confirm predictive value.

21 Apr 2026

Rest tremor in Parkinson’s linked to better-preserved dopamine function

A Finnish clinical imaging study shows that rest tremor in Parkinson's disease is not explained by greater dopamine loss.

23 Mar 2026

Researchers propose that Parkinson’s disease may start in the gut, not the brain

A perspective in The Journal of Clinical Investigation argues that environmental exposures may interact with the gut microbiome and intestinal barrier to trigger biological processes linked to Parkinson’s disease. The authors propose that cumulative environmental stressors can erode host resilience, promoting α-synuclein pathology, immune activation, and neurodegeneration.

5 Mar 2026

Blood gene signals reveal Parkinson’s risk years before diagnosis

Blood-based DNA repair and stress-response signals reveal early molecular changes in Parkinson's disease, aiding in potential early diagnosis and intervention.

2 Feb 2026

Combining stem cell therapy and BDNF enhancement to manage Parkinson’s disease

Parkinson's disease (PD) is an age-related, progressive, neurodegenerative condition, caused by loss of dopamine-producing neurons.

16 Dec 2025

Smartphone motor tests can predict dopamine deficiency in Parkinson’s disease without brain scans

Researchers explore the use of smartphones coupled with clinical scores to evaluate motor function and predict dopamine deficiency.

7 Dec 2025

Optogenetics and artificial intelligence open path to personalized Parkinson’s treatment

Globally recognized figures like Muhammad Ali and Michael J. Fox have long suffered from Parkinson's disease. The disease presents a complex set of motor symptoms, including tremors, rigidity, bradykinesia, and postural instability.

26 Sep 2025

AI spots movement alterations before Parkinson’s symptoms appear

Early detection of even the slightest motor function changes can be critical to slowing the progression of Parkinson's disease. Yet these subtle signs often go unnoticed.

10 Sep 2025

Portable device enables at-home monitoring of Parkinson’s disease symptoms

The number of people living with Parkinson's disease globally has doubled in the past 25 years.

17 Aug 2025

Insights into the brain's switching mechanism could improve Parkinson's treatment

New USC research offers an unseen insight into how the brain shifts gears. The researchers discovered that our innate ability to make quick changes in motor function are the result of a unique brain mechanism.

28 Apr 2025

Human midbrain organoids: A promising tool in the fight against Parkinson's disease

Advancements in organoid technology are crucial for Parkinson's disease research, providing human-relevant models for studying disease and testing therapies.

23 Oct 2024

Machine learning revolutionizes Parkinson's disease symptom tracking and progression prediction

Research develops an automated system using machine learning to quantify motor symptoms in Parkinson's disease and predict disease progression, offering new therapeutic insights.

28 Jul 2024

Efficacy of acupuncture in improving sleep quality for Parkinson's patients

Whether acupuncture improves sleep quality in Parkinson's patients.

1 Jul 2024

New algorithm enhances deep brain stimulation for Parkinson's by targeting specific symptoms

Researchers from Mass General Brigham identified therapeutic targets that may optimize symptom-specific treatment for Parkinson’s disease.

8 Jun 2024

Irritable bowel syndrome not linked to higher Parkinson's risk, study finds

Research investigates the association between irritable bowel syndrome (IBS) and Parkinson's disease (PD), revealing that IBS is not linked to an increased overall risk of PD. Subgroup analyses suggest that certain IBS populations may have a lower risk of developing PD.

31 Mar 2024

Study reveals pivotal insights into the progression of Parkinson's disease

Parkinson's disease, the second most common type of progressive dementia after Alzheimer's disease, affects nearly 1 million people in the U.S. and an estimated 10 million individuals worldwide.

24 Feb 2024

Parkinson's disease a potential pathogenetic factor for coronary artery disease and stroke, study suggests

Researchers performed a two-sample Mendelian randomization (MR) analysis to explore causal associations between Parkinson's disease (PD) and cardio-cerebrovascular diseases.

24 Nov 2023

New gene therapy strategy shows promise for Parkinson's disease

Researchers from the Shenzhen Institute of Advanced Technology (SIAT) of the Chinese Academy of Sciences (CAS) and their collaborators have developed a gene therapy strategy to selectively manipulate Parkinson's disease-affected circuitry and attenuate the core motor symptoms of Parkinson's disease in rodent and nonhuman primate animals.

2 Nov 2023

Wearable devices and machine learning revolutionize Parkinson's disease monitoring

The quantitative progression of motor symptoms of Parkinson's disease (PD) over time using wearable sensor data.

11 Oct 2023

Study upends common belief in what triggers Parkinson's disease

A new Northwestern Medicine study challenges a common belief in what triggers Parkinson's disease.

15 Sep 2023