Carcinogenesis News and Research

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Excess adiposity may alter the immune environment of airways to promote lung cancer

In a recent study of more than a thousand individuals, greater adiposity, or excessive body fat or fatty tissue, specifically in the abdomen, was associated with lung cancer.

8 Oct 2026

Study identifies spatial niche as key to gastric cancer initiation

Early gastric cancer (EGC) represents the most critical yet biologically least understood stage in gastric carcinogenesis.

6 Oct 2026

MIT researchers build cell collection device for early cancer detection

One of the main reasons that ovarian cancer is among the deadliest forms of cancer is timing: When doctors catch it early, the five-year survival rate can be north of 90 percent.

24 Sep 2026

Why might a higher BMI at 20 be linked to lower breast cancer risk later in life?

A large UK cohort study found that higher BMI at age 20 was associated with lower postmenopausal breast cancer risk, while higher BMI in later adulthood was linked to increased risk. Lower VAS percentage mammographic density appeared to explain part of the early-adulthood association, while fibroglandular volume showed a different relationship with life-course adiposity.

20 Sep 2026

Giant-nucleus cells form the foundation of early-stage cancer

Iron is an essential micronutrient, but excess iron can damage cells and increase cancer risk. While many cells die from iron-induced oxidative stress, a subset survives and may become cancerous.

11 Sep 2026

Genetic analysis of 1 million people points to FNIP1 as a promising metabolic target

Mega-scale exome sequencing of 1,032,116 people identified 59 independent genes linked to the TG:HDL ratio, including 44 rare-coding associations not detected in the previous largest analysis. Ultra-rare FNIP1 loss-of-function variants were associated with favorable fat distribution, lower liver fat and glycemia, and around 60% lower odds of a composite cardiometabolic disease outcome.

7 Aug 2026

Occult hepatitis B mutations drive liver cancer growth via Akt mTOR pathway

Occult hepatitis B virus (OBI) infection presents a significant global health challenge, notoriously flying under the radar of standard viral screening while relentlessly driving the pathogenesis of hepatocellular carcinoma (HCC).

22 Jul 2026

Gut microbes emerge as potential players in estrogen-driven cancers

A new review maps how the endocrine-microbiome axis expands the estrobolome concept, showing that gut microbes may alter estrogen recycling, produce hormone-like metabolites, and shape inflammation and tissue environments in hormone-driven cancers. Human evidence remains mostly associative, so the authors call for causal models, longitudinal multi-omics, multi-kingdom profiling, and sex-stratified studies before microbiome-guided cancer strategies enter routine care.

25 Jun 2026

Longer hormone exposure may increase thyroid cancer risk in women

Longer lifetime exposure to female hormones may increase the risk of thyroid cancer in women, according to a study being presented Saturday at ENDO 2026, the Endocrine Society's annual meeting in Chicago, Ill.

14 Jun 2026

Internal mutations and microbes may drive a distinct subtype of oral cancer

A new study reveals that many oral cancers are no longer driven by traditional risk factors like smoking or Human papillomavirus infection.

22 May 2026

Chronic wildfire smoke exposure may raise long-term cancer risks

Exposure to wildfire smoke was associated with a significantly increased risk of lung, colorectal, breast, bladder, and blood cancer, according to results from a study presented at the American Association for Cancer Research (AACR) Annual Meeting 2026, held April 17-22.

21 Apr 2026

Microbial "signatures" within the oral cavity and gut may aid in gastric cancer detection

A recent study published in Cell Reports Medicine has identified distinct microbial "signatures" within the oral cavity and gut that serve as robust biomarkers for the early detection of gastric cancer (GC).

20 Apr 2026

Liver cancer burden rising globally amid shift to metabolic risks

Primary liver cancer continues to pose a major global health challenge, ranking as the third leading cause of cancer-related deaths worldwide.

15 Apr 2026

New pathway found connecting liver congestion to fibrosis and cancer

Researchers from The University of Osaka find that chronic liver congestion is linked to severe liver diseases through a specific signaling pathway in liver sinusoidal endothelial cells - key cells lining the liver's tiny blood vessels.

27 Feb 2026

Polyploidy-induced senescence may influence aging and cancer risk

A new editorial was published in Volume 18 of Aging-US on February 8, 2026, titled "Polyploidy-induced senescence: Linking development, differentiation, repair, and (possibly) cancer?"

18 Feb 2026

New liquid biopsy detects early cancers through epigenetic instability

Researchers at the Johns Hopkins Kimmel Cancer Center have developed a novel liquid biopsy approach to identify early-stage cancers by measuring the random variation in DNA methylation patterns, rather than the absolute level of those patterns as in other liquid biopsies.

2 Feb 2026

How the gut microbiome links obesity to colorectal cancer

The gut microbiome serves as both a biomarker and therapeutic target in diseases like obesity, metabolic syndrome, and colorectal cancer.

28 Nov 2025

Genetic and cellular mechanisms underlying steatotic liver disease

Steatotic liver disease (SLD), mainly encompassing metabolic dysfunction-associated steatotic liver disease (MASLD), alcohol-related liver disease (ALD), and metabolic dysfunction and ALD (MetALD), has emerged as the dominant cause of chronic liver disease worldwide, displacing viral hepatitis as the primary aetiology.

10 Nov 2025

Single-cell analysis reveals HPV-induced keratinocyte heterogeneity in cervical cancer

Cervical squamous cell carcinoma (CESC), the most prevalent subtype of cervical cancer, remains a major global health burden driven primarily by persistent high-risk HPV infection and genetic susceptibility.

7 Nov 2025

Bowhead whale’s secret to long life revealed: precision DNA repair may hold clues for human aging

Researchers discovered that bowhead whales achieve extraordinary longevity and cancer resistance through highly efficient and precise DNA repair mechanisms. A whale-specific protein, CIRBP, enhances genome stability even in human cells, revealing a potential pathway to strengthen DNA repair and slow aging.

30 Oct 2025