Chronic Lymphocytic Leukemia News and Research

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Chronic Lymphocytic Leukemia (CLL) is the most common form of leukemia in adults. According to the American Cancer Society, approximately 8,000 patients will be diagnosed this year. More than 60,000 people in the U.S. currently have CLL. The disease arises in lymphocytes, a type of white blood cell that normally produces antibodies and serves important immune functions.

Patients' responses to oncologists can help predict survival in chronic lymphocytic leukemia

Patients' responses to questions routinely raised by oncologists may provide important clues about their chances of survival from chronic lymphocytic leukemia (CLL), according to a new study published in the journal Therapeutic Advances in Hematology.

7 Sep 2026

Aircrews face highest risk of radiation-related cancer deaths

Of more than 500 occupations in the United States, flight attendants and pilots have the highest and second-highest proportion of radiation-related cancer deaths, a new study has found.

17 Aug 2026

Rare BTK mutation drives resistance to targeted therapies for blood cancer

Scientists at Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine, and collaborators have uncovered a rare genetic mutation that enables some blood cancers to evade both approved Bruton tyrosine kinase (BTK) inhibitors and newer BTK degraders, a finding that could help shape the next generation of therapies for patients with chronic lymphocytic leukemia (CLL) and related malignancies.

27 Jul 2026

Long telomeres linked to higher lymphoma risk in families

Researchers at the Johns Hopkins Kimmel Cancer Center and the Telomere Clinic at Johns Hopkins have identified a genetic syndrome in which unusually long telomeres - the protective caps at the ends of chromosomes - allow immune cells to remain biologically "younger" for longer than normal, predisposing affected individuals to lymphoma and other cancers.

7 May 2026

Novel RNA molecule may influence patient survival in certain blood cancers

In a recent study published in the Proceedings of the National Academy of Sciences (PNAS), researchers at the Texas A&M University Health Science Center (Texas A&M Health) identify a novel RNA molecule that plays a crucial role in preserving the integrity of a key cellular structure, nucleolus (a dense region of the cell containing a subset of crucial genetic material).

2 Feb 2026

Pirtobrutinib shows superior outcomes compared to common first-line combination treatment for CLL/SLL

In a new trial, the Bruton tyrosine kinase (BTK) inhibitor pirtobrutinib increased the rate of survival without disease progression and was well tolerated with a more favorable safety profile when compared with bendamustine plus rituximab (BR) in patients with previously untreated chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL).

10 Dec 2025

Evidence grows for pirtobrutinib as a safer and effective alternative for CLL and SLL

Pirtobrutinib, a non-covalent Bruton tyrosine kinase (BTK) inhibitor, met the primary endpoint for non-inferiority in terms of overall response rate in the first head-to-head comparison with ibrutinib, a covalent BTK inhibitor.

7 Dec 2025

Fixed-duration therapy works as effectively as continuous treatment for chronic lymphocytic leukemia

According to a new trial, patients with chronic lymphocytic leukemia (CLL) show comparable outcomes whether they receive a single-agent treatment indefinitely or a combination treatment for a fixed period of time.

7 Dec 2025

Researchers identify key differences between two subtypes of chronic lymphocytic leukemia

Researchers at the University of Eastern Finland and their international collaborators have identified key developmental and molecular differences between the two main subtypes of chronic lymphocytic leukemia, CLL.

18 Nov 2025

Combination therapy offers hope for ending lifelong chronic lymphocytic leukemia treatment

Ianalumab targets the B-cell activating factor receptor (BAFR) and ibrutinib belongs to a class of therapeutics called Bruton's tyrosine kinase inhibitors (BTKi).

6 Nov 2025

New GoT-Multi technology reveals how cancers evolve and resist treatment

A new tool developed by Weill Cornell Medicine and the University of Adelaide investigators has enhanced the ability to track multiple gene mutations while simultaneously recording gene activity in individual cancer cells.

10 Oct 2025

Nuclear missile workers are contracting cancer. They blame the bases.

At a memorial service in 2022, veteran Air Force Capt. Monte Watts bumped into a fellow former Minuteman III nuclear missile operator, who told him that she had non-Hodgkin lymphoma.

3 Oct 2025

Study reveals early nicotinamide use reduces risk of aggressive skin cancers

A large U.S. Department of Veterans Affairs cohort study found that Nicotinamide use was associated with a 14% lower risk of new keratinocyte skin cancers, driven by a 22% reduction in cSCC and no reduction in BCC. The strongest benefit (56% lower risk) appeared when nicotinamide was started after a patient’s first skin cancer, with diminishing returns after multiple cancers.

18 Sep 2025

City of Hope launches innovative national clinical trials model to expand access to cancer treatments

City of Hope, one of the largest and most advanced cancer research and treatment organizations in the U.S., launched an innovative national clinical trials model to expand access to emerging life-saving cancer treatments to more patients across the country.

9 Sep 2025

Research examines how cancer may invalidate forensic age-estimation tools

Patients with solid tumors, including breast and lung cancers, showed only slightly less accurate results. In contrast, individuals with blood cancers, particularly chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML), sometimes had large errors, with ages overestimated by as much as 50 years.

22 Aug 2025

Chronic Lymphocytic Leukemia News and Research

Further Reading

Patients' responses to oncologists can help predict survival in chronic lymphocytic leukemia

Aircrews face highest risk of radiation-related cancer deaths

Rare BTK mutation drives resistance to targeted therapies for blood cancer

Long telomeres linked to higher lymphoma risk in families

Novel RNA molecule may influence patient survival in certain blood cancers

Pirtobrutinib shows superior outcomes compared to common first-line combination treatment for CLL/SLL

Evidence grows for pirtobrutinib as a safer and effective alternative for CLL and SLL

Fixed-duration therapy works as effectively as continuous treatment for chronic lymphocytic leukemia

Researchers identify key differences between two subtypes of chronic lymphocytic leukemia

Combination therapy offers hope for ending lifelong chronic lymphocytic leukemia treatment

New GoT-Multi technology reveals how cancers evolve and resist treatment

Nuclear missile workers are contracting cancer. They blame the bases.

Study reveals early nicotinamide use reduces risk of aggressive skin cancers

City of Hope launches innovative national clinical trials model to expand access to cancer treatments

Research examines how cancer may invalidate forensic age-estimation tools

Cancer cells hide inside bone marrow fibroblasts to resist treatment

Immunoglobulin replacement therapy not associated with reduced risk of serious infections in patients with CLL

People with Chronic Lymphocytic Leukemia benefit from exercise yet lack personalized guidance

Maestro John Mauceri returns to the stage in renewed health

Next-generation "armored" CAR T cell therapy shows promising results in lymphoma patients

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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