Dyspepsia News and Research

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Indigestion, known as ''upset stomach'' or ''dyspepsia'', meaning hard or difficult digestion, is a medical condition characterized by chronic or recurrent pain in the upper abdomen, upper abdominal fullness and feeling full earlier than expected when eating. It can be accompanied by bloating, belching, nausea, or heartburn.

Digital twin of the gut-brain axis aims to advance neurostimulation therapies

The gut and brain are in constant conversation, exchanging signals that regulate hunger and digestion, as well as the body's response to stress.

3 Aug 2026

Study compares GLP-1 drug benefits and finds substantial variation in clinical effects

GLP-1 receptor agonists improve glycaemic control and provide renal, metabolic, and selective cardiovascular benefits in people with type 2 diabetes, based on an umbrella review of 17 meta-analyses. However, these agents consistently increase gastrointestinal adverse effects and show important distinctions between class-level outcomes and individual drug effects, particularly for semaglutide.

20 Nov 2025

Eating habits tied to Parkinson’s risk: sweets and processed meats raise odds, fruit lowers them

In a large Italian case-control study, researchers identified data-driven dietary patterns linked to Parkinson’s disease risk. Diets rich in sweets, red and cured meats were associated with higher odds of PD, while fruit, especially citrus, was protective.

29 Oct 2025

Daily orforglipron GLP-1 pill achieves over 11% weight loss in global obesity trial

In a phase 3 trial, once-daily oral orforglipron induced significant, dose-dependent weight loss over 72 weeks in adults with obesity but no diabetes. It also improved multiple cardiometabolic markers with a safety profile similar to other GLP-1 receptor agonists.

18 Sep 2025

Gut disorders forecast Alzheimer’s and Parkinson’s risk years before diagnosis

Study maps clinical, genetic, and proteomic links between gut-brain disorders and neurodegeneration, showing how diabetes, vitamin D deficiency, and bowel disorders forecast Alzheimer’s and Parkinson’s years in advance. Multimodal models in biobanks highlight early detection and personalized prevention opportunities.

28 Aug 2025

Transcutaneous vagal nerve stimulation shows promise for gastrointestinal disorders

Imbalanced autonomic function, characterized by reduced vagal activity and sympathetic dominance, is increasingly recognized in various gastrointestinal (GI) disorders.

27 Aug 2025

Helicobacter pylori eradication therapy linked to increased risk of reflux oesophagitis

The management of Helicobacter pylori (H. pylori), a globally prevalent gastric pathogen, has long been centered on its eradication to prevent peptic ulcers, gastric malignancies, and related gastrointestinal complications.

14 Aug 2025

Study confirms post-pandemic rise in disorders of gut-brain interaction

A new international study confirmed a significant post-pandemic rise in disorders of gut-brain interaction, including irritable bowel syndrome (IBS) and functional dyspepsia, according to the paper published in Clinical Gastroenterology and Hepatology.

30 Jul 2025

Scientists link emulsifiers in processed foods to allergy and immune disorders

Review identifies common food additives in ultra-processed foods—particularly emulsifiers like carrageenan and polysorbate 80—as key drivers of gut dysbiosis, inflammation, and allergic diseases by disrupting intestinal barriers and activating proinflammatory pathways.

26 Mar 2025

New study challenges traditional view of functional dyspepsia and gastroparesis

Functional dyspepsia (FD) and gastroparesis (GP) are gastrointestinal disorders often managed as separate conditions.

18 Mar 2025

Real-world evidence highlights safety profile of tirzepatide in managing type 2 diabetes

As more people with type 2 diabetes (T2D) are taking medications to help manage blood sugar levels and weight loss, concerns about whether these drugs are safe have emerged.

12 Sep 2024

Study: GI conditions tied to intracranial aneurysm development and rupture

There is a potential connection between a diagnosis of certain gastrointestinal (GI) syndromes and the formation and rupture of intracranial (brain) aneurysms, according to research presented today at the Society of NeuroInterventional Surgery's (SNIS) 21st Annual Meeting.

22 Jul 2024

Acute gastroenteritis linked to higher rates of irritable bowel syndrome and functional dyspepsia

Researchers examine the prevalence of post-infectious irritable bowel syndrome and post-infectious function dyspepsia following acute gastroenteritis.

18 Jul 2024

IBS after a bout of gastroenteritis may last 4 or more years

Irritable bowel syndrome (IBS)--- characterized by abdominal pain, bloating, and altered bowel habit - may last 4 or more years following a bout of gastroenteritis in around half of those affected, finds a pooled data analysis of the available evidence, published online in the journal Gut.

17 Jul 2024

Study links ultra-processed foods to gut health risks

A review in Nature Reviews Gastroenterology & Hepatology synthesizes evidence on the negative impacts of ultra-processed foods and food additives on gut health, linking them to chronic diseases and alterations in the gut microbiome.

25 Feb 2024

Nutrigenomics paves the way for customized diets in lactose intolerance care

The current evidence on omics tools that allow for developing tailored nutrition strategies for individuals with lactose intolerance (LI).

24 Jan 2024

Migraine linked to increased risk of inflammatory bowel disease in new study

A nationwide cohort study reveals that individuals with migraine have a 1.3-fold higher risk of developing inflammatory bowel disease (IBD), suggesting a significant connection between migraine and IBD.

15 Jan 2024

Exploring the gut-brain link: How diet and nutrient absorption impact digestive disorders

The major disorders of gut-brain interactions (DGBIs).

8 Jan 2024

UK Biobank reveals: Mediterranean diet might be the key to combating 32 chronic diseases!

The association between a healthy dietary pattern and 48 individual chronic diseases among community-dwelling adults.

25 Oct 2023

Oral diabetes and obesity meds danuglipron and orforglipron show promise but have gastrointestinal drawbacks

New orally-administered GLP-1 receptor agonists danuglipron and orforglipron show promise in treating type 2 diabetes and obesity, according to a systematic review. While effective in glycemic control and weight reduction, these drugs come with gastrointestinal side effects that may lead to treatment discontinuation.

17 Oct 2023