Hippocampus News and Research

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The hippocampus is a part of the forebrain, located in the medial temporal lobe. It belongs to the limbic system and plays major roles in short term memory and spatial navigation. Humans and other mammals have two hippocampi, one in each side of the brain.

Liver-derived protein helps protect brain cells and improves memory in Alzheimer's mice

Researchers identified 92 circulating proteins that cross the blood-brain barrier and enter brain tissue, revealing how proteins such as liver-derived APOA1 help regulate astrocyte cholesterol metabolism and support neuronal synapses. In an Alzheimer's disease mouse model, APOA1 transport was impaired, but increasing its production in the liver reduced selected inflammatory and amyloid-related abnormalities, improved synaptic integrity, and enhanced some measures of memory.

12 Nov 2026

Modified zinc finger protein reduces brain plaques in Alzheimer's mice

A KAIST-led research team has found that a protein involved in gene regulation can suppress the harmful aggregation of amyloid-beta, a peptide associated with Alzheimer's disease.

9 Nov 2026

Graded physical activity prescriptions improve functional outcomes in psychiatry

Most of us have heard the advice so often that it has worn smooth, like a stone in a river: get some exercise. A new peer-reviewed Viewpoint in Brain Health, drawing on randomized trials, meta-analyses, and cohort studies, argues that this familiar sentence has been doing the wrong job.

5 Nov 2026

Modified zinc finger scaffold suppresses microglial activation in mouse brain

A KAIST-led research team has found that a protein involved in gene regulation can suppress the harmful aggregation of amyloid-beta, a peptide associated with Alzheimer's disease. The approach also reduced the toxicity of protein aggregates that had already formed.

5 Nov 2026

Eating peanuts every day may change your brains insulin response

The study finds that unsalted peanuts may enhance brain insulin responsiveness, providing new insights into dietary influences on cognitive health in aging.

4 Nov 2026

Gq-coupled receptors activate cAMP signaling to regulate brain synapses

By studying G protein–coupled receptors (GPCRs) in mouse hippocampal slices, Qi Ding and colleagues provide evidence of unconventional receptor signaling that has implications for the function of synapses in the brain.

3 Nov 2026

Excessive exercise disrupts dopamine regulation in the brain, study finds

Excessive physical exercise affects more than just the muscles; it can also alter brain chemistry. A new study published in the journal Neuroscience revealed that exhaustive training without adequate rest alters the regulation of dopamine in the hippocampus, a brain region closely linked to memory and the regulation of emotions.

30 Oct 2026

New microscopy platform enables deeper brain imaging without tissue damage

As light travels deeper into the brain, it scatters. Three-photon microscopy, the current state of the art, reduces the resulting background fluorescence and can, in principle, image much deeper than earlier techniques-but to do that, it uses average laser power limits that cause overheating and damage living tissue.

28 Oct 2026

LINAC-based radiosurgery effectively reduces seizures but causes significant side effects

Drug-resistant epilepsy types, such as mesial temporal lobe epilepsy (MTLE), are surgically managed through anterior temporal lobectomy (ATL).

27 Oct 2026

Prenatal iron deficiency linked to lasting changes in the offspring brain

During the first weeks of pregnancy, developing cells are already laying the foundation for the brain. Iron plays a major role in the organization and shaping of cells during this stage of gestation.

21 Oct 2026

Study links abnormal immature astroglia to lower fluid intelligence in older epilepsy patients

A new USC-led study links abnormal immature astroglia, star-shaped cells that support brain function, to lower fluid intelligence, or the ability to solve new problems, in older adults with epilepsy.

20 Oct 2026

S2N.Bio commences technology transfer of Alzheimer’s cell therapy to Cell Therapies’ Melbourne GMP facility

Cell Therapies Pty Ltd and S2N.Bio (“S2N”) have commenced technology transfer of S2N’s cell therapy candidate for Alzheimer’s disease. The transfer will enable GMP manufacture of clinical trial material for S2N’s first-in-human study in Australia.

20 Oct 2026

A protective brain enzyme may counteract aging-associated cognitive decline

Cinzia Vicidomini, PhD, and Amar Sahay, PhD, of the Mass General Brigham Department of Psychiatry, the Harvard Stem Cell Institute and the Broad Institute of Harvard and MIT, are the lead and senior authors of a paper published in Nature Neuroscience, "An aging-sensitive secreted phospholipase confers neuroprotection and cognitive resilience."

15 Oct 2026

Experimental gene therapy offers non-surgical option for hydrocephalus

Researchers at the University of Cincinnati College of Medicine have published the first proof-of-concept study showing the potential of an experimental gene therapy for hydrocephalus.

14 Oct 2026

Human dental pulp stem cell secretome boosts stroke recovery

Ischemic stroke can leave lasting neurological damage after the initial vascular event, with oxidative stress, neuroinflammation, neuronal death, and disruption of neural connectivity contributing to impaired recovery.

6 Oct 2026

New framework maps depression symptoms to unique brain circuits

A research team from the Sant Pau Research Institute (IR Sant Pau) has published a scientific review proposing a paradigm shift in the way depression is understood and studied.

1 Oct 2026

NSF awards $19 million to build 3D biological observatory for revealing life's smallest structures

How does learning change the wiring of your brain? How does a shark's eye make sense of its underwater world? How does a single-celled parasite cross the barrier that protects the brain? What might neurodegeneration look like at ultra-magnified scale?

24 Sep 2026

Transplanted human cortical organoids filled most of a mouse cortex. Then they began to connect

Researchers created xenocortical mice by transplanting human cortical organoids into animals genetically depleted of much of their native cortex, allowing the human tissue to occupy most of the available cortical space and form anatomical connections throughout the host nervous system. The grafts developed diverse cortical cell types, including L5-ET and VEN-like neurons, generated organized neural activity, and produced measurable cellular and behavioral responses to hypoxic injury.

18 Sep 2026

Study identifies two opposing molecular patterns in autism models

Autism spectrum disorder (ASD) is associated with more than 1,200 risk genes, raising a fundamental question: Do these diverse genetic changes affect the brain in entirely different ways, or do they converge on shared biological mechanisms?

17 Sep 2026

High estrogen alters brain circuit causing temporary memory impairment during pregnancy

Many women usually say the same thing during pregnancy: they walk into a room and forget why, misplace their keys or struggle to follow a conversation.