Hypoxia News and Research

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Hypoxia is a condition in which there is a decrease in the oxygen supply to a tissue. In cancer treatment, the level of hypoxia in a tumor may help predict the response of the tumor to the treatment.

New review outlines role of extracellular vesicles in cancer and aging

A new review was published in Volume 13 of Oncoscience on September 30, 2026, titled "Extracellular vesicles in health, aging and disease."

6 Nov 2026

Ketones may change sleep patterns, but not always for the better

Researchers reviewed animal and human studies and found that ketone bodies may affect sleep stages through energy metabolism and cellular signaling, with the clearest direct evidence involving acetoacetate in mice. They reported mixed human findings and called for controlled studies to separate ketone-specific effects from changes linked to diet, disease, circadian timing, and physiological stress.

28 Oct 2026

Kidney Week 2026 features late-breaking clinical trials in kidney care

The American Society of Nephrology, has selected the following late breaking clinical trials to be presented in-person at Kidney Week 2026 October 22–25.

24 Oct 2026

Combination therapy overcomes immunotherapy resistance in glioblastoma

Scientists at The Wistar Institute have identified a combination treatment that overcomes two of the biggest barriers to immunotherapy in glioblastoma.

8 Oct 2026

Human dental pulp stem cell secretome boosts stroke recovery

Ischemic stroke can leave lasting neurological damage after the initial vascular event, with oxidative stress, neuroinflammation, neuronal death, and disruption of neural connectivity contributing to impaired recovery.

6 Oct 2026

Scientists discover new cell type that may help regulate blood vessel growth in the heart

Researchers have discovered a new cell type that may help regulate blood vessel growth in the heart during development and in response to injury, according to a study from Weill Cornell Medicine.

1 Oct 2026

Review highlights emerging treatments for glioblastoma multiforme

A new research perspective was published in Volume 13 of Oncoscience on September 17, 2026, titled "Emerging pharmacological agents for glioblastoma multiforme: An update on active clinical trials (2025–2026)."

25 Sep 2026

Review highlights how altered metabolism drives kidney cancer growth

Clear cell renal cell carcinoma (ccRCC), the most common subtype of kidney cancer, is increasingly understood as a malignancy shaped by profound changes in cellular metabolism.

24 Sep 2026

Cancer-related DNA changes may appear in blood years before diagnosis

Researchers found that genome-wide plasma cfDNA methylation profiles collected before diagnosis contained early molecular signatures associated with future prostate and breast cancer, with prostate silencer methylation providing the stronger risk stratification. Breast enhancer signals were weaker and varied by subtype and disease stage, indicating that cfDNA methylation may have greater value for risk assessment and surveillance than as a standalone diagnostic test.

23 Sep 2026

Transplanted human cortical organoids filled most of a mouse cortex. Then they began to connect

Researchers created xenocortical mice by transplanting human cortical organoids into animals genetically depleted of much of their native cortex, allowing the human tissue to occupy most of the available cortical space and form anatomical connections throughout the host nervous system. The grafts developed diverse cortical cell types, including L5-ET and VEN-like neurons, generated organized neural activity, and produced measurable cellular and behavioral responses to hypoxic injury.

18 Sep 2026

Tumor environments sculpt diverse natural killer cells for cancer therapies

For decades, natural killer (NK) cells have been classified into two main groups based on surface markers: one specialized for cytokine production and the other for direct killing.

4 Sep 2026

Genetic tool turns soft cancer cells into immune targets

Researchers at the USC Viterbi School of Engineering and Keck School of Medicine of USC have engineered a remarkable genetic tool that addresses one of the most persistent obstacles in cancer immunotherapy: the physical softness of tumors.

11 Aug 2026

Integrated nanomaterials offer new strategies for cancer immunotherapy

Immune checkpoint inhibitors, cancer vaccines and cellular therapies have reshaped oncology, yet most patients still do not achieve lasting benefit.

9 Aug 2026

Casdatifan demonstrates durable responses in advanced kidney cancer trial

A new multi-center clinical study is shedding light on a potential new approach for patients with advanced kidney cancer, offering measurable clinical responses alongside a clearer view into how the disease operates beneath the surface.

27 Jul 2026

Bioresorbable sensor tracks deep-tissue lactate for over 10 days in animals

In animal models, the flexible implant captured local metabolic warning signs before selected systemic measurements and used them to guide earlier resuscitation.

27 Jul 2026

Targeting CMPK2-intervened redox metabolism to mitigate hepatic ischemia-reperfusion injury

HIRI is a major clinical challenge that occurs when blood supply to the liver is temporarily interrupted and then restored, as commonly seen in liver resection and liver transplantation.

16 Jul 2026

Study reveals distinct roles of oxygen-sensing proteins in skeletal muscles

Skeletal muscles-responsible for movement, joint stabilization, and postural support-are highly metabolically active and heavily reliant on oxygen during physical activity.

13 Jul 2026

Hypoxia therapy shows promise for treating mitochondrial brain disorders

Oxygen isn't always a good thing. Of course, people-and most organisms-cannot live without it. But oxygen can also be quite toxic and lead to profound health consequences.

8 Jul 2026

Sleep apnea and erectile dysfunction share a stronger link than expected

A systematic review and meta-analysis of 8 observational studies found that greater obstructive sleep apnea severity was associated with poorer erectile function, with higher AHI linked to lower IIEF scores and higher minimum oxygen saturation linked to higher IIEF scores. The authors caution that the evidence remains observational, heterogeneous, and low certainty, so the findings support targeted screening rather than proving causality.

8 Jul 2026