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Engineered IL-39 cytokine unlocks new pathways for immunotherapy

In a new preclinical study, scientists present a molecular engineering approach to modify and repurpose a cytokine named IL-39, which plays a central role in inflammation and immunity.

5 Nov 2026

DHA improves autism-like behaviors in a preclinical rat study

Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition marked by social and communication difficulties and repetitive behaviors.

3 Nov 2026

Natural plant extract reduces cisplatin-induced kidney injury in mice

Acute kidney injury is common in hospitalized patients and rises sharply in intensive care, yet treatment options remain largely supportive.

3 Nov 2026

Compounds that give citrus fruits their scent may affect gut health

A review published in Food & Function found that dietary terpenoids, naturally occurring compounds in fruits, herbs, and vegetables, can suppress inflammatory signalling and improve intestinal barrier function in laboratory and animal studies. However, human evidence remains limited to two small studies of geraniol-based interventions for irritable bowel syndrome, with further research needed to establish clinical efficacy, appropriate dosing, and long-term safety.

3 Nov 2026

Blueberries reduced blood vessel inflammation in mice, but only with gut microbes present

A preclinical study found that gut microbes help convert blueberry phytochemicals into circulating metabolites, including hippuric acid, that are associated with reduced vascular inflammation. In mice fed a high-fat diet, blueberry supplementation reduced inflammatory markers and monocyte adhesion to blood vessels, but these benefits disappeared following antibiotic-mediated gut microbial depletion.

3 Nov 2026

Study identifies new target to improve ulcerative colitis treatments

Ulcerative colitis (UC) is a chronic, relapsing inflammatory bowel disease in which persistent mucosal inflammation damages the epithelial barrier.

3 Nov 2026

Two healthy diets stood out in a study of more than 7,000 adults

In a cross-sectional analysis of 7,256 adults from the Maastricht Study, researchers found that greater adherence to the DASH and Dutch Healthy Diet patterns was associated with higher very-low-frequency (VLF) heart rate variability power, particularly among participants not taking beta-blockers. No significant associations were observed across time-domain HRV measures after full adjustment, and the findings do not establish that these diets improve cardiovascular function.

2 Nov 2026

Eating walnuts was linked to higher IgG levels, but what does that mean for health?

A two-year randomized trial involving 474 older adults found that daily consumption of 30–60 grams of walnuts was associated with 6% higher total serum IgG concentrations compared with a control diet, with an 11% difference observed among US participants. Walnut consumption did not significantly affect IgM, MDA-LDL or MDA-LDL-specific antibodies, and whether the modest IgG difference has meaningful cardiovascular benefits remains unknown.

1 Nov 2026

FDA approves ILUMYA for adults with active psoriatic arthritis

Sun Pharmaceutical Industries Limited announced today that the U.S. Food and Drug Administration (FDA) has approved the supplemental Biologics License Application (sBLA) for ILUMYA® (tildrakizumab-asmn) for the treatment of adults with active psoriatic arthritis (PsA).

30 Oct 2026

Myeloid immune cells play key roles in aortic health and disease

The aorta is often viewed primarily as the body's largest blood vessel-a durable conduit that delivers oxygen-rich blood from the heart to every organ.

30 Oct 2026

Can broccoli sprouts help with insulin resistance? New review offers clues

A review published in the British Journal of Nutrition examines how carotenoids and bioactive compounds in Brassicaceae microgreens may influence obesity, insulin resistance, and type 2 diabetes through metabolic and inflammatory pathways. Small human trials involving broccoli sprouts have reported improvements in selected metabolic markers, but larger, longer-term studies are needed to establish their clinical benefits.

29 Oct 2026

Researchers find simple way to boost engineered T-cell therapies

Researchers at the UCLA Health Jonsson Comprehensive Cancer Center have identified a promising new strategy to make cancer-fighting immune cells stronger and potentially longer-lasting, a discovery that could help improve the effectiveness of immunotherapies that use a patient's own immune cells to attack cancer.

29 Oct 2026

Nearly one third of patients with advanced melanoma saw tumors disappear completely after receiving TIL therapy plus pembrolizumab immunotherapy

Results from a clinical trial have revealed nearly one third (29.2 percent) of patients with advanced melanoma saw their tumors disappear completely on scans after receiving lifileucel TIL therapy alongside an immune checkpoint inhibitor, pembrolizumab, as a first-line treatment.

24 Oct 2026

Scientists studied one million immune cells and found clues to future disease risk

Researchers developed a single-cell atlas of one million human neutrophils, identifying distinct immune cell populations and gene-expression patterns across tissues, infections, cancer, and other health conditions. Certain neutrophil signatures were associated with metabolic dysfunction, cancer outcomes, and mortality, while higher routine neutrophil counts, even within the normal range, were linked to an increased risk of chronic disease.

22 Oct 2026

Depression profile linked to disrupted sleep and poorer treatment responses

This study uncovers a circadian depression subtype, revealing links between sleep patterns, symptom severity, and antidepressant response in a large cohort.

22 Oct 2026

Semaglutide and teduglutide reduce immune-driven gut injury in mice

Researchers found that gut-derived GLP-1 and GLP-2 signaling helped protect mice against T cell-induced intestinal injury, with GLP-1R primarily regulating inflammation and GLP-2R supporting intestinal repair. Semaglutide and teduglutide, administered separately or together, reduced acute intestinal damage in mice lacking intestinal proglucagon, suggesting potential avenues for investigating treatments for immune-mediated gut injury.

21 Oct 2026

Coffee, citrus and genetics: What scientists found inside human breast milk

In a bioRxiv preprint, researchers analyzed 458 metabolites in breast milk samples from 349 mothers to investigate how maternal diet, genetics, clinical characteristics, and milk-cell gene expression relate to milk composition. Maternal diet explained the greatest share of metabolite variation among the measured maternal factors, while specific genetic variants and gene-expression patterns were associated with individual metabolites, although the study did not establish effects on infant health.

14 Oct 2026

Three months of yoga before surgery revealed a surprising difference in stress hormones

In a non-randomized study of 40 adults with severe obesity awaiting bariatric surgery, researchers found significantly lower plasma noradrenaline levels in yoga participants than in controls after adjusting for baseline measurements. The researchers detected no significant DNA methylation changes in three inflammatory genes and found no clear psychological or metabolic benefits.

12 Oct 2026

Disrupted circadian rhythms may influence tumor immunity and cancer spread

Epidemiological studies link light at night (LAN), shift work, chronic jet lag (CJL), and core clock gene mutations to higher cancer risk and aggressive spread, especially in breast and colorectal cancer.

8 Oct 2026

A hot night changed sleep, anxiety and stress markers

The study highlights how heat exposure affects anxiety and sleep, revealing nighttime heat's broader impact on biological markers linked to stress and health.

7 Oct 2026