Ketamine News and Research

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ANESTHESIOLOGY 2026 to highlight latest advances in anesthesia care

Ketamine given during C-sections could help ease early symptoms of postpartum depression. Common pain relievers, such as ibuprofen, may reduce the risk of delirium after surgery.

11 Aug 2026

Ketamine boosts neuroplasticity through microglia in female brains

Doctors use ketamine on patients as general anesthesia before surgery. They also prescribe it in low doses for pain management, and more recently, it's been used for treatment-resistant depression where other drugs have failed.

31 Jul 2026

Brain immune cells drive recovery from ketamine anesthesia in females

During ketamine anesthesia, the brain's nerve cells fall silent-as consciousness returns, they begin to reconnect.

31 Jul 2026

Research identifies common neuroimmune signatures in rapid-acting antidepressants

In a new study, researchers from The University of Texas MD Anderson Cancer Center have uncovered insights that may help explain how rapid-acting antidepressants, such as ketamine and psychedelics, can reduce symptoms in difficult-to-treat depression.

30 Jul 2026

New review shows why antidepressants often fail in Alzheimer’s and Parkinson’s depression

A Molecular Psychiatry review shows that depression in Alzheimer’s and Parkinson’s disease may reflect disease-specific molecular, neurotransmitter, inflammatory, and circuit-level disruptions rather than standard depression biology alone. It argues that broad antidepressants often show limited efficacy in these patients and that future trials should use biomarkers, neuroimaging, and symptom profiling to guide targeted treatments.

7 Jul 2026

Psychiatry may be moving closer to precision medicine

For decades, treating depression has largely involved a difficult form of medical guesswork: prescribing one antidepressant after another in hopes that one will eventually help.

6 Jul 2026

Scientists map how chronic stress alters somatostatin levels in the brain

Consider the brake. Not the engine, which gets all the attention, but the brake, the quiet thing that decides how fast a system is allowed to go.

1 Jul 2026

Semaglutide, omega-3s and diet shift epigenetic aging clocks in human studies

A systematic review identified 41 human studies evaluating interventions targeting next-generation DNA methylation-based aging clocks. Pharmaceutical, lifestyle, supplement, clinical, and psychosocial interventions shifted some clock outputs, but these biomarkers remain investigational rather than proven clinical surrogates.

16 Jun 2026

Combination therapy shows promise in maintaining lower suicidal thoughts over time

New research published online today in the American Journal of Psychiatry finds that low-dose buprenorphine, given after a single ketamine infusion, significantly sustained reductions in suicidal ideation in adults with major depressive disorder.

19 May 2026

Finding new ways to mimic ketamine’s antidepressant effects

Weill Cornell Medicine investigators have "reverse engineered" ketamine's antidepressant effects to identify potential new strategies for treating depression.

4 May 2026

Brain injury survivors use psychedelics to manage symptoms

A new study from the University of Victoria (UVic) has identified a segment of traumatic brain injury survivors who are using psychedelics to self-medicate for cognitive, mood and somatic symptoms such as headaches.

27 Apr 2026

Psilocybin use rises among Americans amid growing clinical interest

The use of psilocybin, the hallucinogenic compound found in "magic mushrooms," is rising in the United States alongside de‑criminalization efforts in several states and local jurisdictions, as well as heightened interest by the general public.

23 Apr 2026

Psychedelic use is associated with major life changes across 10 domains

Researchers created a new questionnaire to measure major life changes linked to psychedelic use and found that most surveyed adults reporting naturalistic psychedelic use said psychedelics had influenced at least one major change in their lives. These changes most often involved goals, values, and spirituality, were usually rated positively, and were more commonly reported by people with more frequent use.

16 Apr 2026

Hearing loss and sex shape dual-task outcomes in older adults with mild cognitive impairment

Cognitive and physical training can help older adults with mild cognitive impairment (MCI) maintain or improve their ability to move and think simultaneously, but hearing ability and sex influence outcomes, according to a new Concordia-led study.

7 Apr 2026

NOX-1 identified as key molecular target to prolong ketamine's antidepressant effects

Treatment-resistant depression affects a large proportion of people with major depressive disorder, and while ketamine offers rapid relief, its antidepressant effects fade within a few weeks.

30 Mar 2026

Study finds common brain mechanism behind different anesthesia drugs

When patients undergo general anesthesia, doctors can choose among several drugs. Although each of these drugs acts on neurons in different ways, they all lead to the same result: a disruption of the brain's balance between stability and excitability, according to a new MIT study.

17 Mar 2026

PET imaging reveals molecular mechanism behind ketamine's antidepressant effects

Major depressive disorder (MDD) is one of the leading causes of disability worldwide, and approximately 30% of patients develop treatment-resistant depression (TRD), a condition that does not respond adequately to conventional antidepressant therapies.

6 Mar 2026