Kidney Cancer News and Research

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Kidney cancer is usually defined is a cancer that originates in the kidney. The two most common types of kidney cancer, reflecting their location within the kidney, are renal cell carcinoma (RCC) and urothelial cell carcinoma (UCC) of the renal pelvis.

Review highlights how altered metabolism drives kidney cancer growth

Clear cell renal cell carcinoma (ccRCC), the most common subtype of kidney cancer, is increasingly understood as a malignancy shaped by profound changes in cellular metabolism.

24 Sep 2026

Giant-nucleus cells form the foundation of early-stage cancer

Iron is an essential micronutrient, but excess iron can damage cells and increase cancer risk. While many cells die from iron-induced oxidative stress, a subset survives and may become cancerous.

11 Sep 2026

New AI framework improves reliability of cancer pathology diagnosis

Cancer diagnoses directly affect treatment decisions and prognosis and can even have life-altering consequences.

20 Aug 2026

Korean study finds no overall childhood cancer link with maternal diabetes

Researchers followed 549,851 Korean children and found no statistically significant association between maternal diabetes and overall childhood cancer. The analysis linked maternal diabetes to an 81% higher relative risk of urinary tract cancer, but the absolute difference was only 37 additional cases per 100,000 offspring.

4 Aug 2026

Casdatifan demonstrates durable responses in advanced kidney cancer trial

A new multi-center clinical study is shedding light on a potential new approach for patients with advanced kidney cancer, offering measurable clinical responses alongside a clearer view into how the disease operates beneath the surface.

27 Jul 2026

Case study shows how accurate diagnosis can guide personalized treatment for renal oncocytoma

A new case report was published in Volume 17 of Oncotarget on July 2, 2026, titled "Renal oncocytoma: Α case report and literature review."

6 Jul 2026

Allergies show a small but significant link to later cancer risk

A systematic review and meta-analysis of 28 cohort-based studies found a weak but statistically significant association between allergic diseases and later cancer incidence. The signal was strongest in the Western Pacific region and among people with asthma, but high heterogeneity and limited subgroup evidence mean the findings require caution.

5 Jul 2026

New spatial map reveals treatment vulnerabilities in bladder cancer

Researchers at The University of Texas MD Anderson Cancer Center have developed a spatial map of muscle-invasive bladder cancer, revealing how tumor cell states, immune environments and therapeutic vulnerabilities are organized within tumors.

18 Jun 2026

FDA approves new adjuvant treatment option for ccRCC patients with recurrence risk

The U.S. Food and Drug Administration (FDA) has approved pembrolizumab, an immunotherapy, plus belzutifan, a HIF-2α inhibitor, as adjuvant treatment for adult patients with renal cell carcinoma with a clear cell component (ccRCC) at intermediate-high or high risk of recurrence following nephrectomy, with or without resection of metastatic lesions.

12 Jun 2026

New PET tracer offers a powerful tool for kidney cancer staging

A new PET tracer targeting carbonic anhydrase IX (CAIX) has demonstrated exceptional sensitivity and high tumor-to-background contrast in detecting clear cell renal cell carcinoma (ccRCC), according to early clinical research.

1 Jun 2026

Blood test detects tumor DNA to guide advanced cancer treatment

A blood test that detects tumor DNA circulating in the bloodstream may help select the most effective treatment options for cancer patients whose tumors have started to spread, according to one of the largest randomized controlled trials of its kind presented at the Congress of the European Society for Radiotherapy and Oncology (ESTRO 2026).

18 May 2026

Tumor splicing burden predicts treatment response in kidney cancer

Researchers at City of Hope® and TGen (part of City of Hope) have identified a significant correlation between a tumor's "splicing burden" and its clinical response to treatment for metastatic renal cell carcinoma (mRCC).

5 May 2026

New strategy boosts natural killer cells to fight cancer

Scientists have developed a strategy to boost the cancer-fighting power of natural killer (NK) cells, part of the immune system's first line of defense.

24 Apr 2026

Tumor microenvironment drives resistance to ferroptosis in pancreatic cancer

Tumors driven by cancer-driving KRAS mutations are often susceptible to ferroptosis, a type of cell death that can be harnessed for cancer therapy.

2 Apr 2026

Healthy thymus gland linked to longer life and immune stability

The thymus is a small organ located in the upper chest that plays a central role in the immune system: it produces T cells - specialized immune cells that recognize and fight pathogens.

26 Mar 2026

New computational method links individual cells to patient outcomes

A computational method called scSurv, developed by researchers at Institute of Science Tokyo, links individual cells to patient outcomes using widely available bulk RNA sequencing data.

23 Mar 2026

A new standard for preventing post-surgery kidney cancer relapse

Patients with a common form of kidney cancer called clear cell renal cell carcinoma (ccRCC) who have a high risk of recurrence after surgery showed significantly improved disease-free survival when treated with an oral combination regimen that includes belzutifan, a HIF-2α inhibitor, given with standard immune therapy pembrolizumab.

1 Mar 2026