Leukocyte News and Research

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Genetic variant tied to liver injury from blood pressure drugs

This new article publication from Acta Pharmaceutica Sinica B discusses the clinical features and genetic associations of rare liver injury caused by antihypertensive medications.

4 Nov 2026

Kidney Week 2026 features late-breaking clinical trials in kidney care

The American Society of Nephrology, has selected the following late breaking clinical trials to be presented in-person at Kidney Week 2026 October 22–25.

24 Oct 2026

Researchers found a curious mitochondrial pattern in people who moved more

Researchers found that greater self-reported activity, walking, and accelerometer-measured light activity were associated with higher mitochondrial DNA copy number in 256 healthy middle-aged adults. The cross-sectional findings cannot establish causation, and the very low amount of vigorous activity means they do not show that light movement is more beneficial than higher-intensity exercise.

29 Sep 2026

Triple combination therapy trial for HR+/HER2− breast cancer halts early due to toxicity concerns

HR+/HER2− breast cancer constitutes approximately 65–75% of all breast cancer cases worldwide. Although CDK4/6 inhibitors have substantially extended progression-free survival (PFS), up to 60% of patients derive no clinical benefit from these agents, underscoring the urgent need for more effective therapeutic strategies.

28 Sep 2026

Regular exercisers show distinct metabolic and immune signatures in blood

Researchers compared blood samples from 40 regular exercisers and 46 sedentary adults and found differences in metabolites, blood chemistry, and immune cell gene activity. The patterns suggested greater fatty acid use and altered immune signaling among exercisers, but the study could not establish that exercise caused these differences.

21 Sep 2026

Medical breakthrough allows kidney transplant for patient with zero options

An international research team led by the Medical University of Vienna reports on a new treatment strategy that has made a kidney transplant possible for a patient with no realistic chance of receiving a suitable donor organ.

30 Jul 2026

Too little or too much iodine may push immunity off balance

This narrative review finds that adequate iodine supports thyroid hormone signaling, leukocyte metabolism, antioxidant defenses, and antimicrobial activity in humans and domesticated mammals. Both deficiency and sustained excess may impair immunity or promote thyroid inflammation, but precise immune-specific intake thresholds remain uncertain.

27 Jul 2026

Filtered coffee links to slower biological aging while instant coffee shows the opposite

Filtered coffee consumption was associated with slower biological aging, while instant coffee was linked to faster aging in UK Biobank participants. The cross-sectional findings do not prove causation, but they suggest that brewing method may influence coffee’s relationship with aging biomarkers.

20 Jul 2026

New breast cancer classification system predicts immunotherapy response success

The advent of immune checkpoint inhibitors (ICIs) has marked a paradigm shift in cancer treatment, yet a significant portion of breast cancer patients fail to respond to these therapies.

3 Jul 2026

Faster biological aging may help explain rising cancer rates in younger adults

A new study found that later birth cohorts showed greater biological aging, measured by systemic age-gap clocks. Greater biological aging was associated with higher early-onset solid cancer risk, especially lung, gastrointestinal, and uterine cancers.

29 Jun 2026

Faster biological aging may explain rising early-onset cancers

The link between biological aging and early-onset cancer risk offers crucial insights into generational health trends and potential preventive measures.

24 Jun 2026

Scientists reveal how cGAS-STING fuels brain inflammation and neurodegeneration

The cGAS-STING pathway is emerging as a key driver of chronic neuroinflammation through its effects on glial activation, neuronal stress, blood-brain barrier integrity, and type I interferon signaling. The review highlights why selective, context-dependent modulation of cGAS-STING could help treat neurodegenerative diseases, while preserving its essential roles in antiviral defense and tumor surveillance.

10 Jun 2026

A breakthrough molecular discovery could neutralize gluten and protect coeliac patients

A research project led by the Institute for Research in Nutrition and Food Safety (INSA) and the Faculty of Pharmacy and Food Sciences at the University of Barcelona, together with the Molecular Biology Institute of Barcelona (IBMB) of the CSIC (which stands for Consejo Superior de Investigaciones Científicas), has successfully designed and tested a gluten-degrading molecule that is a promising ally in the management of coeliac disease, an autoimmune disease whose symptoms are triggered by the consumption of gluten and other prolamins found in cereals.

14 May 2026

Blood-cell X chromosome loss may predict lower natural fertility

A study reveals that mosaic loss of the X chromosome in blood cells may indicate reduced natural conception likelihood in women, linking fertility and aging.

13 May 2026

Engineered regulatory T cells offer a path toward immunosuppression-free transplants

Organ transplantation remains the cornerstone treatment for end-stage organ failure. While conventional broad-spectrum immunosuppression effectively controls acute rejection, it fails to address chronic rejection and carries long-term side effects including infection, malignancy, and metabolic disorders.

8 May 2026

USF researchers develop AI framework to predict immune system responses

Artificial intelligence is increasingly being used to help scientists accelerate drug discovery and search for new treatments.

6 May 2026

Blood tests years before pregnancy predict risk of hypertension

Pre-pregnancy blood biomarkers linked to hypertension risk highlight the potential for early intervention in managing hypertensive disorders of pregnancy.

5 May 2026

New genomic study tracks rare blood disease in children

Aplastic anemia is a rare, life-threatening blood disorder where patients are unable to make enough blood cells due to the immune system's attack on blood stem cells. The condition can progress to myelodysplastic syndrome (MDS) and leukemia. A study led by scientists at St. Jude Children's Research Hospital, with multiple collaborating institutions, used state-of-the-art genomic techniques to profile 619 children and adults with aplastic anemia.

4 May 2026

How gut imbalance may drive obesity, diabetes, and heart disease

A new review argues that gut dysbiosis is closely linked to metabolic dysfunction through intertwined effects on inflammation, oxidative stress, gut barrier integrity, microbial metabolites, and epigenetic regulation. It also highlights microbiome-targeted strategies such as high-fiber diets, probiotics, prebiotics, postbiotics, exercise, and fecal microbiota transplantation as promising ways to support metabolic health.

30 Mar 2026

APOE4 alters brain immunity and cognition differently in females and males

APOE4 drove sex-specific changes in meningeal immunity, lymphatic drainage, brain lipids, neuroinflammation, and cognition in mouse models, with females showing greater inflammatory and cognitive vulnerability. Suppressing innate immunity improved some cognitive outcomes in female E4/E4 mice but worsened them in male E4/E4 mice, underscoring the need for sex-tailored approaches.

29 Mar 2026