Macrophage News and Research

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A macrophage is a type of white blood cell that surrounds and kills microorganisms, removes dead cells, and stimulates the action of other immune system cells.

UCLA study identifies lipid imbalance as pulmonary fibrosis trigger

A new UCLA Health study in mice has identified a new potential trigger for pulmonary fibrosis: lipid dysregulation (a fat imbalance) within alveolar macrophages.

9 Nov 2026

Immune cell differences may explain sex-specific obesity responses

University of California, Riverside scientists have an explanation for why males and females respond differently to obesity.

6 Nov 2026

Targeted nanoimmunotherapy reduces atherosclerotic plaque burden in mice

This new article publication from Acta Pharmaceutica Sinica B discusses a targeted nanoimmunotherapy designed to restore macrophage clearance of dying cells, promote an anti-inflammatory phenotype, and reduce atherosclerotic plaque burden in mice.

4 Nov 2026

Researchers develop method to generate billions of cDC1 immune cells

Conventional type 1 dendritic cells, known as cDC1 cells, are immune cells that help initiate responses against intracellular pathogens and tumors.

4 Nov 2026

Study identifies new target to improve ulcerative colitis treatments

Ulcerative colitis (UC) is a chronic, relapsing inflammatory bowel disease in which persistent mucosal inflammation damages the epithelial barrier.

3 Nov 2026

Mechanical force triggers metabolic changes that promote orthodontic bone formation

Bone adapts to mechanical force through coupled formation and resorption, a principle central to orthodontics.

30 Oct 2026

Myeloid immune cells play key roles in aortic health and disease

The aorta is often viewed primarily as the body's largest blood vessel-a durable conduit that delivers oxygen-rich blood from the heart to every organ.

30 Oct 2026

Inflammatory macrophages identified as drivers of chronic joint osteoarthritis

Researchers have identified a group of inflammatory macrophages that drive osteoarthritis by sustaining inflammation in the synovium – a layer of connective tissue within joints – and show that they can target these immune cells to treat the disease in mice.

28 Oct 2026

Plasma proteins offer clues to biological aging and mortality risk

A new study published in Geromedicine has identified 17 plasma proteins associated with all-cause mortality in older adults and found that several of these proteins also track with measures of biological aging across multiple organ systems.

27 Oct 2026

Blocking cellular communication reduces the spread of deadly glioblastoma

In a new study published in Cancer Cell, researchers at VIB-KU Leuven reduced the spread of glioblastoma by interrupting specific interactions between the brain's immune cells and tumor cells.

27 Oct 2026

Altered fatty acid metabolism drives glioblastoma growth and treatment resistance

Glioma is the most common primary malignant brain tumor in adults, and glioblastoma (GBM), particularly IDH (Isocitrate dehydrogenase)-wildtype disease, has the poorest prognosis.

21 Oct 2026

Targeting the STING pathway could help prevent osteoporosis

As we age, our bones become weak and brittle, a process called osteoporosis. This bone loss is caused by changes in the cells within the bone marrow microenvironment, such as elevated fat and inflammation-promoting immune cells.

15 Oct 2026

Nasal immune adjuvant protects mice against respiratory viruses for months

The COVID-19 pandemic showed the challenges of protecting populations when a new respiratory virus emerges.

9 Oct 2026

Disrupted circadian rhythms may influence tumor immunity and cancer spread

Epidemiological studies link light at night (LAN), shift work, chronic jet lag (CJL), and core clock gene mutations to higher cancer risk and aggressive spread, especially in breast and colorectal cancer.

8 Oct 2026

Study identifies spatial niche as key to gastric cancer initiation

Early gastric cancer (EGC) represents the most critical yet biologically least understood stage in gastric carcinogenesis.

6 Oct 2026

Restoring cellular recycling helps the body clear harmful zombie cells

As we grow older, our bodies accumulate "zombie cells"-living cells that have stopped dividing or functioning normally-but linger in our tissues, contributing to chronic inflammation and age-related diseases.

5 Oct 2026

Spatial mapping reveals macrophage niches linked to severe COVID-19 lung injury

Researchers at the University of Liège have used imaging-based spatial single-cell transcriptomics to map the cellular organization of lungs from people who died with severe COVID-19.

1 Oct 2026

High-dose taurine aggravates alcohol-induced liver injury, study shows

The researchers first tested whether taurine could compensate for reduced intestinal taurine availability and protect against alcohol-induced liver damage.

30 Sep 2026

Salt-purified seaweed compound suppresses inflammatory and allergic reactions

Food allergies affect an estimated 3%–4% of the global population, yet no definitive cure is currently available.

22 Sep 2026

KAIST researchers develop NUDGE technology to steer cell fate

Which genes need to be controlled to guide a stem cell toward a desired cell type, or to modulate an immune cell's inflammatory response? A Korean research team has developed a general-purpose computational framework that identifies the key targets needed to steer a cell toward a desired state with a single temporary intervention, without permanently altering its genes.

22 Sep 2026