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Advances in chemistry and delivery are taking oligonucleotide medicines beyond rare diseases

A review in Cell Reports Medicine examines how advances in oligonucleotide chemistry and delivery have established ASOs and RNA interference therapies as a class of genetic medicines, with 21 oligonucleotides approved at the time of writing. It also identifies extrahepatic delivery, safety, target validation, individualized treatment, and data quality as priorities as the field expands into common diseases and explores AI-assisted development.

24 Sep 2026

Semaglutide’s heart benefits may extend beyond weight loss

Semaglutide is known to reduce the risk of serious heart disease. However, a new study published in the European Heart Journal today (Thursday) suggests that this effect cannot not be entirely explained by patients losing weight on the drug.

23 Sep 2026

Screening approved medicines reveals potential treatments for preterm labor

Shajila Siricilla, PhD, Assistant Professor of Pediatrics, and Jennifer Herington, PhD, Associate Professor of Pediatrics, led a team that systematically screened 1,191 FDA-approved drugs and found that several candidates met criteria supporting further evaluation as potential treatments for preterm labor.

23 Sep 2026

Aurora Microplates wins Best in Showcase at the 2026 LRIG-NYC Spring Expo for CELLAZIP™

Aurora Microplates, a Zeon company, announced that its CELLAZIP™ microplate coating received the Best in Showcase award at the 2026 LRIG-NYC Spring Expo, presented by the Laboratory Robotics Interest Group of New York City.

From Aurora Microplates 23 Sep 2026

Regular exercisers show distinct metabolic and immune signatures in blood

Researchers compared blood samples from 40 regular exercisers and 46 sedentary adults and found differences in metabolites, blood chemistry, and immune cell gene activity. The patterns suggested greater fatty acid use and altered immune signaling among exercisers, but the study could not establish that exercise caused these differences.

21 Sep 2026

Experimental RNA therapy enhances weight loss while preserving lean muscle

GLP-1 drugs have revolutionized obesity treatment, but they can lead people to lose muscle mass along with fat. And when patients stop treatment, they often regain their weight - primarily as fat.

21 Sep 2026

Core muscle activity rapidly regulates blood flow in the brain

Engaging core muscles - through movement, exercise, or even coughing - may be a key regulator of blood flow in the brain.

21 Sep 2026

Personalized programs make no difference in preventing elderly falls

Personalized programs designed to reduce falls in older people may make no difference to how often people fall, according to the most comprehensive research review to date.

21 Sep 2026

Cohesin protein protects genetic information during cell division

Cell division, a process fundamental to life, still holds surprises. Researchers from the University of Zurich and the Spanish National Cancer Research Centre (CNIO) have discovered a key mechanism that allows cells to protect genetic information as they divide.

21 Sep 2026

MIT researchers develop noninvasive way to spot aging zombie cells

As we age, some of the cells in our body enter a state of senescence, in which they stop dividing but do not die. Those senescent cells can contribute to age-related disorders such as cancer, tissue degeneration, and inflammatory diseases.

21 Sep 2026

New mRNA vaccine expands flu protection options for older adults

Every fall, millions of Americans heed the call to get their annual flu shot. Getting vaccinated reduces the risk of severe illness, hospitalization, and death from influenza.

20 Sep 2026

Adenine base editing slows neurodegeneration in hereditary motor neuron disease

A team of researchers led by Professor Haruhisa Inoue (Center for iPS Cell Research and Application, Kyoto University) and Professor Yuishin Izumi (Tokushima University) demonstrated that adenine base editing can correct a disease-causing genetic mutation and alleviate neurodegeneration in hereditary motor and sensory neuropathy with proximal dominant involvement (HMSN-P), providing proof of concept for a precision gene therapy for inherited motor neuron diseases.

18 Sep 2026

NUS scientists harness magnetic pulses to reprogram immune cells to fight breast cancer

Researchers from the National University of Singapore (NUS) have demonstrated an innovative approach for targeted breast cancer therapy using pulsed electromagnetic fields (PEMFs).

18 Sep 2026

Ultrasound stimulation reduces deep calf muscle stiffness to prevent injuries

Muscle strain injuries are a common problem in sports, and injuries to the triceps surae, the calf muscle group that includes the gastrocnemius and soleus, can significantly affect athletic performance and return to play.

18 Sep 2026

Better fitness was linked to healthier brain structure, but not better memory

Researchers studying 353 cognitively unimpaired adults aged 60 to 94 found that higher muscular capacity was associated with lower basal ganglia perivascular space volume, while greater aerobic fitness was associated with greater gray matter volume and medial temporal lobe thickness. Fitness was not directly associated with global cognition or episodic memory, and evidence for cognitive reserve was limited, although VO₂max explained additional variation in delayed verbal memory beyond tau burden.

18 Sep 2026

Study highlights drop in harmful medication use among adults with cognitive disorders

Adults 65 and older with cognitive disorders such as dementia, are more likely to suffer negative effects from drugs that treat central nervous system conditions including anxiety, sleep problems and psychosis.

17 Sep 2026

US health officials knowingly relied on flawed vaccine safety algorithm

US health officials knowingly relied on a compromised algorithm to detect signals of harm from mRNA covid-19 vaccines and silenced efforts to fix it, finds an investigation published by The BMJ today.

17 Sep 2026

First US patient receives a mind-controlled bone-anchored bionic arm

A Chicago-area man is set to become the first person in the United States to receive a bionic arm connected directly to his bone, nerves and muscles - an advanced prosthesis designed to be controlled by his own neural signals and return sensory feedback in real time.

17 Sep 2026

Time-restricted eating may slow early-stage Huntington's disease

A simple change in when people eat may offer a promising new approach for Huntington's disease, according to research led by Oregon Health & Science University.

17 Sep 2026

Some mice showed signs of stress resilience before the stress even began

Researchers found that mice later classified as resilient showed stronger coordination between neuronal OFF-periods and slow-wave activity in the prelimbic cortex even before social stress. After social defeat, resilient mice also showed a distinct reorganization of neuronal silence during NREM sleep, linking local sleep dynamics with behavioral resilience.

17 Sep 2026