Oophorectomy News and Research

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Oophorectomy is the surgical removal of an ovary or ovaries. The surgery is also called ovariectomy, but this term has been traditionally used in basic science research describing the surgical removal of ovaries in laboratory animals.

Study finds oral hormone replacement therapy increases venous thromboembolism risk

Current use of oral menopausal hormone therapy (commonly known as hormone replacement therapy or HRT) is associated with an increased risk of blood clots in legs / lungs regardless of dose or treatment duration, finds a large Danish study published by The BMJ today.

23 Sep 2026

Menopause leaves a blood protein signature linked to brain aging and Alzheimer’s risk

Researchers identified a 16-protein blood signature associated with menopause that tracked more strongly with reproductive hormones than chronological age and was largely replicated in an independent UK Biobank cohort. Higher menopause proteomic scores were also associated with less favorable proteomic aging estimates and poorer cognitive outcomes in older women, including incident Alzheimer’s dementia, although the observational evidence does not establish causality.

23 Sep 2026

HRT linked to lower dementia risk, but timing and menopause type matter

In a UK Biobank study of 183,450 postmenopausal women followed for an average of 13.3 years, hormone replacement therapy use was associated with a modestly lower risk of dementia, with stronger associations in women who had surgical menopause or shorter natural estrogen exposure. The relationship also varied by age at HRT initiation, while the observational design means the findings cannot establish that HRT prevents dementia.

27 Aug 2026

Longer hormone exposure linked to healthier brain aging in women

Research indicates that hormonal therapies and later menopause are associated with increased brain volume and thickness, promoting healthier aging.

26 Jun 2026

Menopause may raise women’s Alzheimer risk earlier than doctors once thought

This review argues that women’s higher Alzheimer disease risk may be shaped in part by midlife neuroendocrine aging, especially the menopause transition, rather than by longevity alone. It highlights early menopause, bilateral oophorectomy, vasomotor symptoms, and midlife cognitive changes as underinvestigated but potentially important risk markers, while calling for sex-specific, biomarker-driven prevention strategies.

18 Mar 2026

Vaginal estrogen therapy is safe for young endometrial cancer survivors, study finds

Despite the increased incidence of endometrial cancer in younger women, there is limited research regarding the safety of local, low-dose vaginal estrogen therapy (ET) for survivors.

4 Mar 2026

Hormone replacement therapy shows no rise in overall mortality

Menopausal hormone therapy (commonly known as hormone replacement therapy or HRT) is not associated with an increased risk of death, finds a Danish study of over 800,000 women published by The BMJ today.

18 Feb 2026

Menopausal hormone therapy shows no added breast cancer risk for BRCA carriers

Using menopausal hormone therapy (MHT) was not associated with an increased risk of breast cancer in women with inherited mutations in the BRCA1 or BRCA2 genes, according to the results of a matched prospective analysis presented at the San Antonio Breast Cancer Symposium (SABCS), held December 9-12, 2025.

12 Dec 2025

Early menopause increases risk of metabolic syndrome in women

The prevalence of metabolic syndrome, a dangerous and potentially deadly condition, increases with menopause.

21 Oct 2025

Surgical menopause associated with higher risk of workforce exit

Menopause before the age of 45 (known as early menopause) is associated with an increased risk of an array of serious diseases, including cardiovascular disease and osteoporosis.

8 Oct 2025

Survey shows ongoing misconceptions about hormone therapy safety in cancer survivors

Despite evidence suggesting the safety of hormone therapy for patients with a history of low-grade endometrial or epithelial ovarian cancer, a new survey shows that many gynecologists and some gynecologic oncologists are still uncomfortable prescribing the therapy for this patient population.

10 Sep 2025

Study links hysterectomy and bilateral oophorectomy to higher stroke risk

Given the seriousness and increased frequency of strokes, many studies have been conducted to assess the relationship between hysterectomy and/or bilateral oophorectomy and the risk of stroke with varying results.

3 Sep 2025

Study finds link between epigenetic aging and colorectal cancer risk in postmenopausal women

A new research paper was published in Volume 17, Issue 7 of Aging (Aging-US) on July 7, 2025, titled "Epigenetic age and accelerated aging phenotypes: a tumor biomarker for predicting colorectal cancer."

19 Aug 2025

Are you at risk? Waist size, not weight, could affect fertility in women

Researchers found that higher relative fat mass (RFM), a measure of visceral body fat, is significantly associated with increased infertility risk in U.S. women aged 20–44. The study suggests RFM may be a more sensitive screening tool for infertility risk than traditional BMI, especially in women with normal weight but high visceral fat.

3 Jul 2025

Study links hormone therapy to breast cancer risk in younger women

Scientists at the National Institutes of Health (NIH) have found that two common types of hormone therapy may alter breast cancer risk in women before age 55.

1 Jul 2025

Mayo Clinic researchers discover how ovarian cancer may begin

Little is known about what causes ovarian cancer, and there is no way to detect it early yet. About 75% of the time when someone is diagnosed with ovarian cancer, it has already progressed to stage 3 or stage 4, which means it has spread to other parts of the body.

24 Jun 2025

Ovary and fallopian tube removal linked to lower death risk in BRCA carriers with breast cancer

Women diagnosed with breast cancer who carry particular BRCA1 and BRCA2 genetic variants are offered surgery to remove the ovaries and fallopian tubes as this dramatically reduces their risk of ovarian cancer.

8 May 2025

Oophorectomy linked to higher risk of heart failure in women

Women of childbearing age who had both ovaries removed, in a procedure called bilateral oophorectomy, were more likely to develop heart failure later in life, according to a study being presented at the American College of Cardiology's Annual Scientific Session (ACC.25).

20 Mar 2025

GP reveals seven ways to relieve endometriosis symptoms

In the UK, one in 10 women has Endometriosis. With March marking Endometriosis Awareness Month, Dr Bhavini Shah, a GP from LloydsPharmacy Online Doctor, reveals ways to relieve endometriosis symptoms.

19 Mar 2025

Research shows epigenetic aging in the blood as potential breast cancer marker

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) on December 5, 2024, Volume 16, Issue 22, titled "DNA-methylation age and accelerated epigenetic aging in blood as a tumor marker for predicting breast cancer susceptibility."

21 Jan 2025