Sarcopenia News and Research

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New framework guides safer obesity drug prescribing in older adults

Today, the American Geriatrics Society (AGS) released a new framework to assist clinicians to safely prescribe obesity medications in older adults.

29 Oct 2026

Sarcopenia should be treated as a motor system disease

An older patient mentions that the stairs have become harder. They have stopped carrying the shopping in from the car. Last month they had a fall in the kitchen.

26 Oct 2026

Rice, fish and pickles: Is the traditional Japanese diet as healthy as we think?

A systematic review of 37 studies found that greater adherence to predefined Japanese-style dietary patterns was associated with lower all-cause and cardiovascular mortality, based on pooled evidence from three cohort studies. However, health associations varied according to dietary composition, suggesting that traditional Japanese diet scores alone may not adequately distinguish the potential benefits and risks of different food combinations.

20 Oct 2026

Does extra protein protect aging muscle during fasting?

A randomized trial found that alternate-day fasting reduced weight in older men, while added protein and leucine did not prevent lean mass loss.

7 Oct 2026

Is a high-protein diet hard on your kidneys?

From temporary changes in kidney filtration to the competing nutritional needs of older adults and children, researchers examine when high protein intake may shift from adaptation to concern.

5 Oct 2026

$Vitamin B12 deficiency was linked to higher fracture hazard after 50$

Vitamin B12 deficiency was linked to higher fracture hazard after 50

A study links abnormal vitamin B12 levels to fracture risk, highlighting a complex relationship beyond simple deficiency in middle-aged and older adults.

2 Oct 2026

Trevogrumab cuts semaglutide-induced lean mass loss by half, study shows

New research to be presented at the Annual Meeting of The European Association for the Study of Diabetes (EASD) in Milan, Italy (Sept 28 – Oct 2) and in press with The Lancet shows that using the trevogrumab to inhibit myostatin, a protein that negatively regulates muscle mass, can reduce lean mass loss during treatment with semaglutide by 50% compared with semaglutide and placebo.

1 Oct 2026

Early-onset type 2 diabetes trial demonstrates significant 24-week fat loss

New research to be presented at the Annual Meeting of The European Association for the Study of Diabetes (EASD) in Milan, Italy (Sept 28 – Oct 2) and published in The Lancet Regional Health Americas journal shows that in people who have developed early onset type 2 diabetes (EOT2D) (aged under 45 years), around half these T2D cases can be reversed with a low-energy diet combined with a structured exercise program.

1 Oct 2026

Your voice could add something aging blood tests and scans miss

Researchers found that a standardized 30-second voice recording could predict chronological age with mean absolute errors of 3.95 years in females and 4.41 years in males. The resulting Voice Age measure also captured physiological information partly distinct from molecular, imaging, sleep, and lifestyle-based aging clocks, supporting its potential as a functional aging biomarker.

15 Sep 2026

The obesity-microbiome story is more complicated than ‘good’ and ‘bad’ bacteria

This review finds that obesity is linked to reciprocal interactions between diet, the gut microbiome, microbial metabolites, and host metabolic pathways that influence appetite, insulin sensitivity, inflammation, and energy balance across the lifespan. It highlights diet as a particularly tractable way to influence this system, while emphasizing that microbiome changes associated with GLP-1 therapies remain difficult to separate from weight loss and that functional multi-omics approaches may help enable more personalized interventions.

3 Sep 2026

From caffeine to trigonelline, coffee has surprising links to muscle biology

A scoping review of 54 studies found that coffee and several coffee-derived bioactive compounds influence pathways linked to skeletal muscle metabolism, including insulin signaling, mitochondrial function, oxidative stress, inflammation, glucose uptake, and protein turnover. Human studies reported associations with greater muscle mass and lower frailty or functional impairment, but most evidence remains observational or preclinical and cannot establish causality.

25 Aug 2026

How well you balance and move may say more about longevity than you think

Objective fitness testing in 13,423 older adults in Taiwan found that higher physical fitness was consistently associated with lower all-cause mortality over a median seven years. Balance and agility, lower-body strength, and cardiorespiratory fitness showed the strongest associations, while a composite fitness score produced the steepest mortality gradient.

11 Aug 2026

Researchers suggest a potential therapeutic strategy for muscle loss associated with obesity

Obesity has been linked to skeletal muscle loss and deterioration. While M2 macrophages may play a role in regulating muscle function, the underlying mechanisms remain poorly understood.

4 Aug 2026

Restricting select amino acids may mimic protein restriction’s healthy aging benefits

A review finds that restricting protein, particularly methionine, isoleucine, and valine, may improve metabolism and influence key aging pathways, largely in experimental models. Short human studies suggest metabolic benefits, but effects on lifespan remain unknown and restriction may harm people with unmet or increased protein needs.

3 Aug 2026