Septic Shock News and Research

RSS

Researchers put olive and fish oil IV nutrition under the microscope

A systematic review of six randomized trials compared olive-oil-based and fish-oil-containing parenteral nutrition in hospitalized adults, examining infection, inflammation, oxidative stress, liver function, and clinical outcomes. The included studies involved diverse patient groups and lipid formulations, with substantial variation in outcomes and insufficient evidence for a meta-analysis.

18 Aug 2026

UH College of Pharmacy secures funding for three major health studies

University of Houston College of Pharmacy researchers have secured more than $1 million in new funding to support three separate studies targeting sepsis, Alzheimer's disease and related dementias, and depression in patients with sickle cell disease.

11 Aug 2026

NEWS2 score may improve antibiotic decisions in suspected sepsis

A study of nearly 100,000 adults treated for suspected infection suggests that the National Early Warning Score (NEWS2), a score based on routinely collected vital signs that is widely used to identify patients at risk of clinical deterioration, may help clinicians identify which patients are most likely to benefit from immediate antibiotic treatment and which may safely undergo further evaluation before receiving antibiotics.

6 Aug 2026

Bioresorbable sensor tracks deep-tissue lactate for over 10 days in animals

In animal models, the flexible implant captured local metabolic warning signs before selected systemic measurements and used them to guide earlier resuscitation.

27 Jul 2026

Collaborative AI system helps accelerate clinical trial design

An artificial intelligence system that operates like a collaborative team of medical experts could accelerate clinical trial design, one of the most difficult steps in drug development, according to a new study by Weill Cornell Medicine investigators.

7 Jul 2026

Metformin reduces long COVID risk according to ACTIV-6 clinical trial

New findings from the ACTIV-6 randomized clinical trial provide important confirmation of prior clinical trial results that metformin, a widely available and inexpensive medication with an established safety record, reduced the risk of clinician-diagnosed long COVID when started during acute COVID-19 infection.

11 Jun 2026

Large clinical trial shows both common septic shock fluids are equal

A randomized clinical trial conducted across five countries in 47 pediatric emergency departments, including Ann & Robert H. Lurie Children's Hospital in Chicago, established that both commonly used IV fluids for treating septic shock – balanced crystalloid fluid and 0.9% saline – are equally safe and effective. Results were published in the New England Journal of Medicine.

5 Jun 2026

New AI tools identify potential drugs for rare Ebola virus

Recent advances in artificial intelligence have enabled Southwest Research Institute (SwRI) to identify nearly two dozen antiviral compounds that could potentially treat a rare species of Ebola virus (Bundibugyo virus) currently affecting the Democratic Republic of Congo.

26 May 2026

Study identifies protein essential for repairing damage after inflammation

Whenever there is a wound or infection, the body produces an inflammatory response. This is the body's first line of defense, and macrophages — cells of the innate immune system — play a key role: first, they help eliminate pathogens and other infectious agents, and then they trigger the mechanisms that repair the damage caused during the inflammatory process.

28 Apr 2026

Noninvasive brain monitoring reveals hidden oxygen deprivation in ICU patients

In neurological intensive care, it is quickly learned that the brain cannot wait. As the most sensitive organ in the human body, it can sustain irreversible damage after just a few minutes of severe hypoxia.

27 Apr 2026

Study finds different types of crystalloid fluids are equally effective for pediatric sepsis

A major study, led by researchers at Children's Hospital of Philadelphia, Nemours Children's Health, and Children's National Hospital and involving an extensive network of medical centers across the United States and abroad, found that different types of crystalloid fluid resuscitation were equally effective for staving off the most serious adverse kidney events after the treatment of pediatric patients with suspected septic shock.

25 Apr 2026

WHO-recommended antibiotics ineffective for many neonatal sepsis cases

A major multi-country study has found that WHO-recommended first-line antibiotics for neonatal sepsis are likely to be effective in only one quarter of infections in low- and middle-income countries (LMICs).

20 Apr 2026

The 0.05 EU/mg breakthrough: How Sino Biological ProPure™ is redefining the Ultra-Low Endotoxin standard

When we discuss bacterial infections, we often think of exotoxins—those soluble proteins actively secreted by bacteria—while overlooking endotoxins, which are more insidious but equally dangerous.

From Sino Biological Inc. 12 Mar 2026

Artificial lung keeps patient alive after lung removal

Researchers evaluate the effectiveness of a novel extracorporeal total artificial lung system to enable bilateral pneumonectomy in patients with severe ARDS.

5 Feb 2026

Phase II clinical trial shows promising results for novel sepsis drug

Griffith University researchers may have unlocked the secret to treating sepsis, with a Phase II clinical trial in China successfully concluding with promising results.

14 Jan 2026

Gut microbe metabolite TMA improves blood sugar by shutting down a key inflammatory switch

Researchers identified trimethylamine (TMA) as a gut microbe–derived metabolite that directly inhibits IRAK4 to reduce metabolic inflammation and improve glycaemic control in high-fat-diet-fed mice. Choline-driven increases in TMA production replicated these benefits, revealing a host–microbe signaling axis with therapeutic potential for obesity-associated insulin resistance.

9 Dec 2025

Evolving epidemiology of invasive Group A Streptococcus in critical care

Streptococcus pyogenes or invasive Group A Streptococcus (iGAS) is a major clinical concern around the world, since iGAS infections can quickly escalate into life-threatening conditions such as necrotizing fasciitis, septic shock, and pneumonia.

6 Nov 2025

Novel vaccine strategy could solve the challenge of implanted device infections

Patients with implanted medical devices like orthopedic joint replacements, pacemakers, and artificial heart valves run a small but significant risk that these devices get infected with bacterial pathogens.

4 Nov 2025

New method detects sepsis infections in just two hours

A new diagnostic method would confirm sepsis infections earlier, cutting critical hours in the "race against time" to save patients' lives.

28 Aug 2025

Methylene blue emerges as an adjunct in septic shock

Recent evidence suggests methylene blue may help reduce vasopressor needs and ICU stays in septic shock, but current data do not support replacing standard therapies. Further research is needed to clarify its optimal dosing, timing, and patient selection for best outcomes.

26 Jun 2025