Spleen News and Research

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Multi-million dollar grants aim to advance hairy cell leukemia research

The Hairy Cell Leukemia Foundation and Blood Cancer United®, formerly The Leukemia & Lymphoma Society, today announced six new research grants as part of their ongoing strategic partnership to better understand what drives hairy cell leukemia and find better therapies on the road to cures for this rare form of blood cancer.

24 Sep 2026

Sex-specific biological clocks reveal how aging differs across the body in women and men

Researchers developed 38 sex-specific biological aging clocks across 15 organ systems, finding differences between females and males in genetic architecture, molecular signatures, disease associations, and mortality patterns. Brain aging clocks were linked to progression from mild cognitive impairment to Alzheimer’s disease in both sexes and to sex-dependent cognitive trajectories among solanezumab-treated A4 participants, while the authors stressed that sex-pooled and sex-interaction models remain complementary approaches.

17 Sep 2026

Cannabis-derived nanovesicles showed early antitumor potential in mice

Researchers developed a Cannabis sativa hairy root culture system that produced stable plant-derived nanovesicles capable of promoting dendritic cell maturation and activating T-cell responses through TLR2- and TLR4-associated signaling. Oral administration also restored selected immune responses in immunosuppressed mice and suppressed tumor growth in an E.G7 lymphoma model, providing preliminary evidence for their immunomodulatory and antitumor potential.

15 Sep 2026

Spleen imaging features may reveal coronary artery disease risk

A new study led by investigators from Mass General Brigham reveals that certain features in the spleen hidden within imaging scans may signal a person's risk of coronary artery disease (CAD), suggesting targets for prevention and treatment.

9 Sep 2026

Study uncovers cellular mechanisms behind long-lasting antibody responses

A team led by investigators from the University of Osaka uncovers cellular mechanisms that favor long-lived antibody responses, providing insights that may help researchers design vaccines that provide longer-lasting protection against infection.

9 Sep 2026

Targeted MS treatment protects the overall immune system

UZH researchers have developed a novel therapy for multiple sclerosis that is designed to stop the misguided immune response without suppressing the immune system as a whole.

1 Sep 2026

Researchers traced lifelong obesity resistance in mice back to an early microbial encounter

Natural wild-derived microbiota protected mice against diet-induced obesity across sexes, genetic backgrounds, and age by increasing energy expenditure and promoting a thermogenic program in brown adipose tissue. The effect depended on the immune system’s initial encounter with the microbiota and required CCR2-associated myeloid activity, revealing a long-lasting microbiota-immune-brown fat pathway.

25 Aug 2026

Deep-learning tissue clocks reveal how organs age and leave disease-linked signals in blood

Deep learning applied to more than 25,000 histopathology slides revealed tissue-specific structural signatures of biological aging that tracked telomere attrition, pathology, comorbidity, and molecular changes more closely than chronological age alone.

18 Aug 2026

Researchers uncover mechanism linking skin inflammation to body-wide allergies

Our bodies experience allergic reactions when the immune system mistakenly overreacts to harmless substances, known as allergens, such as pollen, dust, or certain foods.

6 Aug 2026

Malaria infection causes permanent damage to the spleen immune cells

Macrophages formed in the bone marrow can only assume the function of embryonal phagocytes, or "scavenger cells," to a certain degree according to a study by the University of Bonn and the Peter Doherty Institute for Infection and Immunity at the University of Melbourne.

4 Aug 2026

Study shows how solid food shapes immune system development

In a mouse model, LMU researchers have discovered a signaling pathway through which diet influences the development of the immune system.

4 Aug 2026

Too little or too much iodine may push immunity off balance

This narrative review finds that adequate iodine supports thyroid hormone signaling, leukocyte metabolism, antioxidant defenses, and antimicrobial activity in humans and domesticated mammals. Both deficiency and sustained excess may impair immunity or promote thyroid inflammation, but precise immune-specific intake thresholds remain uncertain.

27 Jul 2026

Lifestyle changes improve MASLD by suppressing key molecular pathway

Lifestyle modification is the cornerstone of managing metabolic dysfunction-associated steatotic liver disease (MASLD), a growing cause of chronic liver disease worldwide.

23 Jul 2026

Researchers identify immune cell receptor that drives organ aging process

We may age at different rates, but none of us escapes aging. A study in mice and in human cells by Stanford Medicine researchers pins much of the blame on a particular type of immune cell's increased inability, with advancing age, to gobble up another immune cell type.

16 Jul 2026

Antifungal nanoparticles made from immune cell membranes fight infections

Tiny particles made from the membranes of human immune cells could offer a promising new way to fight fungal infections that are becoming harder to treat. Engineers at the University of California San Diego created antifungal nanoparticles that target Candida albicans, a fungus responsible for oral and vaginal yeast infections as well as life-threatening bloodstream infections.

9 Jul 2026

Gut immune cells help prevent severe salmonella infections

Widely recognized as the face of food poisoning, salmonella bacteria lurk in raw meat and poultry, on pets and in unpasteurized dairy products.

7 Jul 2026

Scientists find link between bacterium in the gut ecosystem and lupus

Scientists at UT Health San Antonio, the academic health center of The University of Texas at San Antonio, found a link between a bacterium in the gut microbiome, or ecosystem, and lupus, which could lead to more effective treatment of the disease, in a study published in Nature Communications.

25 Jun 2026

New cell culture method allows targeted study of antibody regulation

For the immune system to effectively combat pathogens, antibody responses must be precisely controlled. So-called follicular regulatory T cells (Tfr cells) play a key role in this process by limiting excessive immune responses and helping to maintain immune tolerance.

25 Jun 2026

Review outlines how donor imaging improves liver transplantation outcomes

Liver transplantation often depends on decisions made under pressure. In deceased donation, teams must quickly judge whether a liver is suitable, whether fat accumulation could threaten graft function, and whether unexpected vascular anatomy may complicate procurement or implantation.

22 Jun 2026

Aging immune cells may explain why autoimmunity rises later in life

A new Review reveals how aging can push the immune system into a paradoxical state, weaker against threats yet more prone to attacking the body’s own tissues.

21 Jun 2026