neoplasia News and Research

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Phase 3 clinical trial enrolls first platinum-resistant ovarian cancer patient

The GOG Foundation, Inc. is proud to announce the enrollment of the first patient in GOG-3132/BEHOLD-Ovarian01 (NCT07286266), a global Phase 3 clinical trial titled A Randomized, Open-label, Multicenter, Phase 3 Study to Investigate Mocertatug Rezetecan Compared With Standard of Care in Participants with Platinum-resistant Ovarian Cancer.

27 Jul 2026

Study links GLP-1 treatment to fewer alcohol drinking days

Current GLP-1 receptor agonist prescriptions were associated with modestly lower AUDIT-C scores in a large, diverse US cohort. The difference appeared to reflect less frequent drinking rather than fewer drinks per occasion or fewer binge-drinking episodes.

13 Jul 2026

Microbiome science merges with oncology for better cancer treatments

Cancer remains notoriously difficult to treat, partly because tumors co‑opt their surrounding environment, including the resident microbiota, to evade immune surveillance and resist conventional therapies.

7 Jul 2026

HPV vaccination linked to sharp decline in cervical cancer deaths

High-income countries that initiated widespread administration of the Human Papilloma Virus (HPV) vaccine in the mid-2000s have experienced substantial declines in cervical cancer cases, marking a significant achievement in medicine.

18 Jun 2026

Scientists reveal why common pancreatic precancer lesions rarely turn deadly

Spatial and single-cell analyses of human donor pancreata showed that PanIN epithelial cells gradually acquire cancer-like molecular features, while their surrounding stromal and immune environment remains closer to normal pancreatic tissue. The findings suggest that delayed or incomplete microenvironmental reprogramming may help explain why most PanIN lesions remain indolent rather than progressing to pancreatic cancer.

24 May 2026

Researchers discover unexpected cellular triggers for precancerous pancreas lesions

In an unexpected finding, a new study flips on its head researchers' understanding of how precancerous pancreas lesions evolve into pancreatic cancer.

21 May 2026

GLP-1 drugs promise wider health benefits, but experts urge caution on use

GLP-1 receptor agonists are reshaping care for type 2 diabetes, obesity, chronic kidney disease, and obstructive sleep apnea, with evidence for glycemic, weight-loss, cardiovascular, and renal benefits. The review urges nurse practitioners to balance expanding clinical promise with careful prescribing, patient education, monitoring, access advocacy, and vigilance for gastrointestinal, endocrine, pregnancy-related, and rare serious risks.

27 Apr 2026

Study explores if wastewater can track colorectal cancer at population level

A proof-of-concept study shows that cancer-linked RNA can be detected in wastewater, raising the possibility of tracking colorectal cancer patterns across communities without relying on individual screening.

19 Mar 2026

Personalized counseling program helps cervical cancer survivors quit smoking

A new study led by UCLA researchers suggests that a personalized counseling program can significantly help women who have survived cervical precancer or cervical cancer to quit smoking - and does so at a cost that researchers say represents good value for healthcare systems.

12 Mar 2026

Extra copies of chromosome 1q may play key role in the earliest stages of pancreatic cancer

Researchers at the Johns Hopkins Kimmel Cancer Center and its Ludwig Center uncovered new evidence that extra copies of a specific chromosome segment - chromosome 1q - may play a key role in the earliest stages of pancreatic cancer development.

26 Feb 2026

Menstrual blood HPV testing accurately detects cervical precancer

A study reveals menstrual blood can effectively screen for HPV, matching clinician-collected samples in accuracy, enhancing cervical cancer detection globally.

9 Feb 2026

Lifetime heavy drinking sharply raises colorectal cancer risk, major US study finds

Lifetime alcohol intake, not just recent drinking, is associated with colorectal cancer risk in older adults followed in the PLCO Cancer Screening Trial. Heavy and consistent long-term drinking was linked to higher colorectal cancer risk, while alcohol cessation was associated with lower odds of early, nonadvanced adenomas.

28 Jan 2026

New federal guidelines shift cervical cancer screening to HPV testing

New cervical cancer screening guidelines emphasize self-collection and hrHPV testing, aiming to increase screening rates and improve women's health outcomes.

8 Jan 2026

New analysis reveals fundamental flaws in widely used measures of biological aging

A landmark review published today in Genomic Psychiatry challenges researchers to fundamentally reconsider how the field measures and conceptualizes biological aging.

3 Dec 2025

AGA updates guidelines for Barrett's Esophagus to catch cancer early

The American Gastroenterological Association (AGA) released a new clinical practice guideline on the surveillance of Barrett's esophagus, the only known precursor to esophageal cancer (adenocarcinoma), a highly lethal cancer whose incidence has risen substantially over recent decades.

21 Oct 2025

Belzutifan demonstrates strong clinical activity in two rare neuroendocrine tumors

A multicenter Phase II clinical trial led by researchers at The University of Texas MD Anderson Cancer Center demonstrated significant tumor shrinkage and disease control in patients with advanced pheochromocytoma and paraganglioma (PPGL), two rare and potentially life-threatening neuroendocrine tumors.

18 Oct 2025

New software MaGNet automates analysis of breast tissue branching architecture

Branching isn't just for trees. This biological process occurs in animal development, enabling organs to perform complex functions. Branch-like structures form in lungs, kidneys, and breasts, among other places. Importantly, only in female mammary glands does most branching occur years after birth.

3 Oct 2025