Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

Optibrium’s Quantum Mechanics and Machine Learning Methods Predict Routes of Drug Metabolism

Peer-reviewed study published in Xenobiotica describes an innovative new method that predicts the routes and products of Phase I and II metabolism with high sensitivity and greater precision than other approaches.

From Optibrium Ltd. 7 Dec 2023

MedUni Vienna scientists discover new pain medication with fewer side effects

People with chronic pain are often dependent on drugs from the class of opioids with sometimes considerable side effects.

6 Dec 2023

Camena Bioscience appoints Dr. Nicola Thompson as Chair of the Board

Camena Bioscience, a synthetic biology company providing genes to the pharmaceutical and biotechnology industries, today announced it has appointed Dr Nicola Thompson as Chair of its Board of Directors.

From Camena Bioscience 6 Dec 2023

'GREAT PLEA' system proposed for responsible use of generative AI in healthcare

A study in NPJ Digital Medicine reviews ethical guidelines for AI in military and healthcare, proposing the "GREAT PLEA" system for ethical AI application in clinical research.

5 Dec 2023

Research uncovers stealthy strategy of SARS-CoV-2 infection

Researchers have discovered a novel mechanism whereby the SARS-CoV-2 virus, which causes COVID-19, can vary its mode of infection in human cells. Published in the journal eLife, a team from the University of Minnesota and the Midwest Antiviral Drug Discovery (AViDD) Center found the virus can alternate between being highly infectious and avoiding detection by the immune system.

5 Dec 2023

Government’s £2 billion plan sets out to harness the power of engineering biology

The government's £2 billion vision to seize the enormous potential of engineering biology - an exciting field of biology which could transform how we sustainably grow food, create medical treatments and produce fuel - will be unveiled by Science, Research and Innovation Minister Andrew Griffith today (Tuesday 5 December).

5 Dec 2023

The past, present and future of automation and digitalization in the life sciences laboratory

In this interview, News-Medical talks to Dr. Klaus Lun and Chris Mason about the past, present and future of automation and digitalization in the life sciences laboratory and especially the impact this could have on next-generation sequencing and genomics.

From Tecan 5 Dec 2023

CN Bio PhysioMimix Organ-on-a-Chip data supports Inipharm’s INI-822 for metabolic liver disease treatment now in clinical testing

CN Bio today announced its PhysioMimix® assay for Non-alcoholic steatohepatitis (NASH).

From CN-Bio 4 Dec 2023

UK Biobank unveils world's largest genetic data set

In a momentous landmark for medical research, UK Biobank has today [Thursday 30 November] unveiled incredible new data from whole genome sequencing of its half a million participants.

4 Dec 2023

Hevolution-AFAR New Investigator Awards expanded with $16 million grant

The American Federation for Aging Research (AFAR), is pleased to announce a $16 million expansion of the Hevolution-AFAR New Investigator Awards in Aging Biology and Geroscience Research, a grant program to enable early-career investigators with labs in the US and Canada to research healthspan-expanding therapeutics and treatments.

1 Dec 2023

New drug combination may improve treatment for rare nerve sheath tumors

Combining a pair of experimental drugs may help treat malignant peripheral nerve sheath tumors with fewer harmful side effects, according to preliminary animal studies led by investigators at the Johns Hopkins Kimmel Cancer Center and Johns Hopkins Drug Discovery.

1 Dec 2023

Genetic evidence suggests thiazide diuretics reduce kidney stone risk

Kidney stones affect nearly 10% of the global population. For more than three decades, thiazide diuretics, a common medication used for high blood pressure, have been the standard of care for kidney stone prevention because they reduce the excretion of urinary calcium.

30 Nov 2023

C-Path's TRxA and Celdara Medical announce MOU to identify and advance promising new therapeutics

Critical Path Institute's (C-Path) Translational Therapeutics Accelerator (TRxA) and Celdara Medical today announced the signing of a Memorandum of Understanding (MOU) aimed at identifying and advancing promising new therapeutics in areas of high unmet medical need.

29 Nov 2023

UK Biobank data opens door to new era of precision medicine

In a momentous landmark for medical research, UK Biobank has today [Thursday 30 November] unveiled incredible new data from whole genome sequencing of its half a million participants.

29 Nov 2023

Insilico Medicine hosts three webinars to unveil latest technology breakthroughs

Insilico Medicine ("Insilico"), an artificial intelligence (AI)-driven, clinical stage biotechnology company and leader in AI drug discovery platform technology, is hosting three webinars unveiling its latest technology breakthroughs Nov. 28-30, 2023.

29 Nov 2023

New heart organoid model could revolutionize drug development and toxicology studies

Heart disease kills 18 million people each year, but the development of new therapies faces a bottleneck: no physiological model of the entire human heart exists – so far.

28 Nov 2023

Unveiling a new cardiac myosin inhibitor through AI-driven virtual screening

Discovery of a novel cardiac-specific myosin modulator.

28 Nov 2023

CN Bio wins ‘Most Impactful Industry Collaboration of the Year’ at the OBN Awards 2023 for ongoing research with the FDA

CN Bio has received the ‘Most Impactful Industry Collaboration of the Year’ at the 2023 OBN Awards.

From CN-Bio 23 Nov 2023

Almirall and Absci partner to develop AI-designed therapeutics for dermatological diseases

Almirall S.A., a global biopharmaceutical company focused on medical dermatology, and Absci Corporation, a generative AI drug creation company, today announced a drug discovery partnership aimed to develop and commercialize AI-designed therapeutics to fight chronic and debilitating dermatological diseases. The partnership combines Absci’s Integrated Drug Creation™ platform with Almirall’s dermatological expertise with the goal of delivering life-changing medicines to patients, marking another step forward in AI drug creation.

20 Nov 2023

TACTIC project aims to uncover genetic causes of cancer and develop targeted therapies

Investigating the genetic causes of cancer and fighting them with new drugs: To this end, German Cancer Aid is funding the TACTIC project until 2028 with 11.8 million euros.

16 Nov 2023

Drug Discovery News and Research

Further Reading

Optibrium’s Quantum Mechanics and Machine Learning Methods Predict Routes of Drug Metabolism

MedUni Vienna scientists discover new pain medication with fewer side effects

Camena Bioscience appoints Dr. Nicola Thompson as Chair of the Board

'GREAT PLEA' system proposed for responsible use of generative AI in healthcare

Research uncovers stealthy strategy of SARS-CoV-2 infection

Government’s £2 billion plan sets out to harness the power of engineering biology

The past, present and future of automation and digitalization in the life sciences laboratory

CN Bio PhysioMimix Organ-on-a-Chip data supports Inipharm’s INI-822 for metabolic liver disease treatment now in clinical testing

UK Biobank unveils world's largest genetic data set

Hevolution-AFAR New Investigator Awards expanded with $16 million grant

New drug combination may improve treatment for rare nerve sheath tumors

Genetic evidence suggests thiazide diuretics reduce kidney stone risk

C-Path's TRxA and Celdara Medical announce MOU to identify and advance promising new therapeutics

UK Biobank data opens door to new era of precision medicine

Insilico Medicine hosts three webinars to unveil latest technology breakthroughs

New heart organoid model could revolutionize drug development and toxicology studies

Unveiling a new cardiac myosin inhibitor through AI-driven virtual screening

CN Bio wins ‘Most Impactful Industry Collaboration of the Year’ at the OBN Awards 2023 for ongoing research with the FDA

Almirall and Absci partner to develop AI-designed therapeutics for dermatological diseases

TACTIC project aims to uncover genetic causes of cancer and develop targeted therapies

Drug Discovery - Second Edition eBook

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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