The INNOVANCE® VWF Ac assay from Siemens Healthineers is a sensitive, reliable, and convenient test system for direct, WHO-standardized determination of von Willebrand factor (VWF) activity.

It employs an advanced new technology, allowing the assay to mimic the way in which WVF binds to glycoprotein lb (GPlb), the major VWF receptor protein on platelets. Because the recombinant receptor protein includes two gain-of-function mutations, the assay does not require risocetin.

Features and benefits

Recommended screening method

A basic assay is the favored screening technique for detecting quantitative and qualitative defects of the von Willebrand factor.

Direct determination of VWF activity

The INNOVANCE VWF Ac assay instantly identifies the activity of VWF. As a result of the gain-of-function mutations, VWF binding to GPIb does not need ristocetin (VWF:GPIbM) and is less vulnerable to the effects of some polymorphism variants.

Excellent correlation to the gold-standard method

The INNOVANCE VWF Ac assay correlates with the ristocetin cofactor-based BC von Willebrand Reagent assay.

Improved VWF testing workflow

The assay uses a user-friendly liquid reagent that does not need stirring.


Technical specifications

. .
15 μL 
 Required sample volume on Sysmex® CS-2500 and CS-5100 Systems
4–600% of norm
Measuring range
16 hours
Onboard stability on Sysmex CS-2500 and CS-5100 Systems
12 days
Onboard stability on Atellica® COAG 360 System3
Within-device CV of Control Plasma N on the Atellica COAG 360 System3
~100 tests
Number of tests per kit

Source: Siemens Healthineers

Assay performance can vary from country to country as well as corresponding to the system application of the respective assay. The values listed above are provided as examples only.

INNOVANCE VWF Ac kit components

The INNOVANCE VWF Ac assay is a turbidimetric, latex-based assay that utilizes a liquid, user-friendly reagent. The assay comprises three components and could be ordered as a kit.

INNOVANCE® VWF Ac assay for WHO-standardized determination of VWF activityImage Credit: Siemens Healthineers

Available on Siemens Healthineers and Sysmex Systems

INNOVANCE VWF Ac assay applications come with Atellica COAG 360 and BCS® XP Systems from Siemens Healthineers and Sysmex CN-3000/60003, CS-2500/5100, and CA-660 Systems.

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