Biochemistry

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Study reveals molecular mechanisms of drug resistance in Mycobacterium tuberculosis

A consortium of researchers from Russia, Belarus, Japan, Germany and France led by a Skoltech scientist have uncovered the way in which Mycobacterium tuberculosis survives in iron-deficient conditions by utilizing rubredoxin B, a protein from a rubredoxin family that play an important role in adaptation to changing environmental conditions.

9 Apr 2021

Novel diarylamides show promise as orally active diuretics to treat hyponatremia

Urea transporters (UT) play a vital role in the mechanism of urine concentration and are recognized as novel targets for the development of salt-sparing diuretics. Thus, UT inhibitors are promising for development as novel diuretics.

8 Apr 2021

Research offers an efficient approach to mine the chemical diversity of endophytic fungi

Endophytic fungi are promising producers of bioactive small molecules. Bioinformatic analysis of the genome of an endophytic fungus Penicillium dangeardii revealed 43 biosynthetic gene clusters, exhibited its strong ability to produce numbers of secondary metabolites.

8 Apr 2021

PNA-based gene editing technique can advance gene discovery

In an article published in the April 8 issue of Nature, the National Institutes of Health's Somatic Cell Gene Editing Consortium provided a detailed update on the progress of their nationwide effort to develop safer and more effective methods to edit the genomes of disease-relevant somatic cells and reduce the burden of disease caused by genetic changes.

8 Apr 2021

Mouse model provides new understanding about Folling Disease

In Norway, all newborn children are tested for 25 rare genetic diseases through the Newborn Screening program, and the most common of these is phenylketonuria (abbreviated to PKU), known as Folling Disease.

7 Apr 2021

New biomarker of glucocorticoid action could help clinicians to tailor treatments

Researchers have uncovered pathways involved in the body's response to glucocorticoid treatments and identified a novel biomarker that could be used to monitor how these drugs work in patients, according to a clinical study published today in eLife.

6 Apr 2021

New RNA-sequencing method can help detect numerous modified small RNAs

A team led by a biomedical scientist at the University of California, Riverside, has developed a new RNA-sequencing method-- "Panoramic RNA Display by Overcoming RNA Modification Aborted Sequencing," or PANDORA-seq -- that can help discover numerous modified small RNAs that were previously undetectable.

5 Apr 2021

New bioprinting process uses ultrashort peptides to print hydrogel scaffolds

A new automated process prints a peptide-based hydrogel scaffold containing uniformly distributed cells. The scaffolds hold their shapes well and successfully facilitate cell growth that lasts for weeks.

5 Apr 2021

Scientists use a novel two-step method to track receptor proteins

The neurons in our nervous system "talk" to each other by sending and receiving chemical messages called neurotransmitters.

3 Apr 2021

Chemical inhibitor can reduce SARS-CoV-2's ability to infect host cell lines

James McKerrow, MD, PhD, dean of the Skaggs School of Pharmacy and Pharmaceutical Sciences at University of California San Diego, has long studied neglected tropical diseases -- chronic and disabling parasitic infections that primarily affect poor and underserved communities in developing nations.

3 Apr 2021

Russian researchers develop a safe, inexpensive packed eggs surface disinfection technology

Russian researchers have developed an inexpensive, safe, and reliable packed eggs surface disinfection technology.

3 Apr 2021

Researchers develop new AI-based strategy to assess beef freshness

Although beef is one of the most consumed foods around the world, eating it when it's past its prime is not only unsavory, but also poses some serious health risks.

1 Apr 2021

Mice study provides insight into the beneficial effects of selenium supplementation

Adding the nutrient selenium to diets protects against obesity and provides metabolic benefits to mice, according to a study published today in eLife.

30 Mar 2021

Study reveals how exercise during pregnancy confers metabolic health benefits in offspring

A mechanism has been identified that explains how physical exercise in pregnancy confers metabolic health benefits in offspring.

30 Mar 2021

Microbiota-derived molecules do not change the entry or replication of SARS-CoV-2 in intestinal cells

A study conducted at the University of Campinas in the state of São Paulo, Brazil, shows that compounds produced by gut microbiota (bacteria and other microorganisms) during fermentation of insoluble fiber from dietary plant matter do not affect the ability of the novel coronavirus SARS-CoV-2 to enter and replicate in cells lining the intestines.

30 Mar 2021

Drinking beetroot juice promotes oral bacteria linked to healthier blood vessels and brain function

Drinking beetroot juice promotes a mix of mouth bacteria associated with healthier blood vessels and brain function, according to a new study of people aged 70-80.

30 Mar 2021

Scientists use specially designed gold nanoparticles to 'seek out' bone stem cells

Researchers at the University of Southampton have developed a new way of using nanomaterials to identify and enrich skeletal stem cells - a discovery which could eventually lead to new treatments for major bone fractures and the repair of lost or damaged bone.

29 Mar 2021

Biochemistry

Study reveals molecular mechanisms of drug resistance in Mycobacterium tuberculosis

Novel diarylamides show promise as orally active diuretics to treat hyponatremia

Research offers an efficient approach to mine the chemical diversity of endophytic fungi

PNA-based gene editing technique can advance gene discovery

Mouse model provides new understanding about Folling Disease

New biomarker of glucocorticoid action could help clinicians to tailor treatments

New RNA-sequencing method can help detect numerous modified small RNAs

New bioprinting process uses ultrashort peptides to print hydrogel scaffolds

Scientists use a novel two-step method to track receptor proteins

Chemical inhibitor can reduce SARS-CoV-2's ability to infect host cell lines

Russian researchers develop a safe, inexpensive packed eggs surface disinfection technology

Researchers develop new AI-based strategy to assess beef freshness

Mice study provides insight into the beneficial effects of selenium supplementation

Study reveals how exercise during pregnancy confers metabolic health benefits in offspring

Microbiota-derived molecules do not change the entry or replication of SARS-CoV-2 in intestinal cells

Drinking beetroot juice promotes oral bacteria linked to healthier blood vessels and brain function

Scientists use specially designed gold nanoparticles to 'seek out' bone stem cells

Heidelberg researchers introduce a reproducible division mechanism for synthetic vesicles

Research sheds light on a new neuroprotective mechanism to control damage following brain injury

POSTECH researchers produce artificial lung model using 3D printing

How microRNA is transforming science: From discovery to diagnostics

Advancing benzodiazepine detection

The Surgeon-Scientist Pioneering Regenerative Engineering

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