Cell Biology

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Manipulating voltage patterns in tumor cells reduces breast cancer metastasis in animal models

In normal cells, electrical voltage patterns provide a blueprint for orderly growth. But with cancer, the opposite happens.

11 Jan 2022

Novel mechanism linking intercellular adhesion molecule with genetic skin diseases discovered

Northwestern Medicine investigators have discovered a novel mechanism linking an intercellular adhesion molecule with genetic inflammatory skin diseases, according to findings published in the Journal of Clinical Investigation.

11 Jan 2022

First patient-derived stem cell model developed for studying oculocutaneous albinism

Researchers at the National Eye Institute have developed the first patient-derived stem cell model for studying eye conditions related to oculocutaneous albinism (OCA).

11 Jan 2022

Modular super-enhancer regulates gene expression involved in retina development

Enhancers are regions of DNA that do not code for proteins, but control how genes are expressed. Super-enhancers are clusters of enhancers that together regulate genes with important roles in cell identity.

11 Jan 2022

Mapping peripheral blood glycoprotein profiles of COVID-19 patients

A team of researchers recently analyzed differential protein glyco-isoform distributions of symptomatic and asymptomatic coronavirus disease 2019 patients.

11 Jan 2022

Maternal transfer of healthier gut bacteria helps neonates to resist biliary atresia

Biliary atresia is a rare disease that occurs when a delicate tree-like set of ducts that carry bile from the liver to the intestine becomes scarred and blocked. While some treatments can slow the damage, most children who develop biliary atresia will die without a liver transplant.

10 Jan 2022

Locust study reveals a ‘surprisingly simple’ approach to recognize an odor

Smell a cup of coffee. Smell it inside or outside; summer or winter; in a coffee shop with a scone; in a pizza parlor with pepperoni - even at a pizza parlor with a scone! - coffee smells like coffee.

10 Jan 2022

Researchers develop new biopsy technology for profiling multiple tumor microenvironment biomarkers

A team led by University of California, Irvine researchers has developed a new biopsy technology that can profile multiple tumor microenvironment biomarkers simultaneously, revealing cellular spatial organization and interactions that will help advance personalized disease diagnosis and treatment.

10 Jan 2022

Scientists unravel how blood cells mount the first line of defense against viruses

Scientists have just slotted into place a big piece of the puzzle that explains how our blood cells mount their first line of defense against viruses.

10 Jan 2022

Scientists discover antibody that inhibits a broad range of sarbecoviruses

Scientists have discovered an antibody that may lead to more effective treatments against a wide range of sarbecoviruses, the family of viruses that includes the coronavirus SARS-CoV-2 and their variants.

7 Jan 2022

Small cluster of neurons in the brain stem found to coordinate vocalization with breathing

The vocal sounds of humans - laughing, crying, and the babbling of babies - have the same rhythmic quality as the sounds made by many mammals, songbirds, and even some species of fish.

7 Jan 2022

New research may help better understand the causes of human diseases

New University of Gloucestershire research aims to increase our understanding of the causes of human diseases, potentially leading to the design of better treatments in the future.

7 Jan 2022

Bacterial biofilms use a developmental patterning mechanism seen in plants and animals

Over the past several years, research from University of California San Diego biologist Gürol Süel's laboratory has uncovered a series of remarkable features exhibited by clusters of bacteria that live together in communities known as biofilms.

7 Jan 2022

Grouping tumors by 'immune archetypes' points the way to personalized immunotherapies

The UCSF researchers, led by first co-authors Alexis Combes, PhD, and Bushra Samad, MS, and senior author, Max Krummel, PhD, obtained tumor specimens from 78 UCSF clinicians, and surveyed 364 tumors biopsies from patients and categorized them into groups based on their immune microenvironment.

7 Jan 2022

Research uncovers how a mouse brain understands sensory information

The brain is the most complex organ in our body – constantly absorbing and interpreting our surroundings, and guiding our movement, thoughts, behaviors and emotions.

6 Jan 2022

New approach with mRNA preparation reprograms T cells to attack heart fibroblasts

An experimental immunotherapy can temporarily reprogram patients' immune cells to attack a specific target via only a single injection of messenger RNA (mRNA), similar to the mRNA-based COVID-19 vaccines, according to a new study from researchers in the Perelman School of Medicine at the University of Pennsylvania.

6 Jan 2022

Researchers study immune cell invasion process in living fruit fly embryos

To fight infections and heal injuries, immune cells need to enter tissue. They also need to invade tumors to fight them from within.

6 Jan 2022

Study reinforces the link between microglia and some cases of brain disease

Certain subtle differences in DNA sequences are known to raise the chances a person may develop Alzheimer's or Parkinson's disease.

6 Jan 2022

Researchers explore novel strategy to improve the reprogramming efficiency of human fibroblasts

Not too long ago the idea of taking, for instance a skin cell and transforming it into a muscle cell was unthinkable. About 10 years ago, however, revolutionary research showed that it is indeed possible to reprogram differentiated adult cells into other types fully capable of conducting new functions.

6 Jan 2022

Scientists unravel how LPS prevents or promotes development of allergic disease

Immunologists have long been baffled by LPS, the bacterial lipopolysaccharide that helps form the cell walls of Gram-negative bacteria.

5 Jan 2022

Cell Biology

Manipulating voltage patterns in tumor cells reduces breast cancer metastasis in animal models

Novel mechanism linking intercellular adhesion molecule with genetic skin diseases discovered

First patient-derived stem cell model developed for studying oculocutaneous albinism

Modular super-enhancer regulates gene expression involved in retina development

Mapping peripheral blood glycoprotein profiles of COVID-19 patients

Maternal transfer of healthier gut bacteria helps neonates to resist biliary atresia

Locust study reveals a ‘surprisingly simple’ approach to recognize an odor

Researchers develop new biopsy technology for profiling multiple tumor microenvironment biomarkers

Scientists unravel how blood cells mount the first line of defense against viruses

Scientists discover antibody that inhibits a broad range of sarbecoviruses

Small cluster of neurons in the brain stem found to coordinate vocalization with breathing

New research may help better understand the causes of human diseases

Bacterial biofilms use a developmental patterning mechanism seen in plants and animals

Grouping tumors by 'immune archetypes' points the way to personalized immunotherapies

Research uncovers how a mouse brain understands sensory information

New approach with mRNA preparation reprograms T cells to attack heart fibroblasts

Researchers study immune cell invasion process in living fruit fly embryos

Study reinforces the link between microglia and some cases of brain disease

Researchers explore novel strategy to improve the reprogramming efficiency of human fibroblasts

Scientists unravel how LPS prevents or promotes development of allergic disease

How innovation in dried blood spot testing is transforming neurological disease monitoring

Unlocking live single-cell functional insights

How microRNA is transforming science: From discovery to diagnostics

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