Cell Biology

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Repressing a protein that facilitates DNA repair to potentiate chemotherapy

Chemotherapy kills tumor cells by causing damage to them. One of the most effective ways of causing damage is to prevent the two DNA strands from separating so that the cellular machinery cannot read the instructions written in the genes.

15 Jun 2021

Differential localization may explain different physiological functions of receptors

In the heart there are two different subtypes of beta-adrenergic receptors - beta1 and beta2 - which are activated by the stress hormones adrenaline and noradrenaline.

15 Jun 2021

Molecular biologists elucidate the key role of motor proteins in cell division

Proper chromosome segregation into two future daughter cells requires the mitotic spindle to elongate in anaphase.

15 Jun 2021

Researchers reveal the role of hypothalamic astrocytes in obesity-related hypertension

Researchers have succeeded for the first time in demonstrating the role of hypothalamic astrocytes in obesity-related hypertension.

15 Jun 2021

Cancer cells use an aging gene to establish permanent footing

Researchers at the University of Helsinki and the Beatson Institute for Cancer Research in Glasgow have discovered how mutated cells promote their chances to form cancer. Typically, the accumulation of harmful cells is prevented by active competition between multiple stem cells in intestinal glands, called crypts.

15 Jun 2021

Change in diet and circadian clock can impact healthy fat tissue, finds study

Changing your eating habits or altering your circadian clock can impact healthy fat tissue throughout your lifespan, according to a preclinical study published today in Nature by researchers with The University of Texas Health Science Center at Houston.

15 Jun 2021

New wound gap closure mechanism may offer faster, better healing after injury or surgery

The observation of a previously undetected biological mechanism for closing gaps in living tissue improves basic understanding of the wound-healing process and may one day inform strategies to speed healing after surgery, according to a team of Penn State and Singapore researchers.

14 Jun 2021

Study creates a new model of Alzheimer's disease progression

Alzheimer's disease is the most common form of dementia and is characterized by neurodegeneration in regions of the brain involved in memory and learning. Amyloid beta and tau are two toxic proteins that build up in disease and cause eventual neuronal death, but little is known about how other cells in the brain react during disease progression.

14 Jun 2021

Researchers discover two new types of glial cells in the brain

Neurons, nerve cells in the brain, are central players in brain function. However, a key role for glia, long considered support cells, is emerging.

14 Jun 2021

Researchers study what happens in brain cells affected by Alzheimer's disease

Studies on tissue from patients and mini-brains made from stem cells shed light on the disease.

14 Jun 2021

Hair follicle stem cells play an outsize role in healing skin blisters

A team of scientists has shown that the healing of skin blisters is driven by hair follicle stem cells, which delay their own development in the process.

14 Jun 2021

Novel method may overcome current limitations in mouse bone marrow transplantation models

To study the immune system in human health and disease, scientists commonly use the genetic manipulation of mouse hematopoietic stem and progenitor cells (HSPCs) as a powerful model system.

14 Jun 2021

PhoreMost appoints Christian Dillon as Vice President of Biology

PhoreMost Ltd today announced it has appointed Dr Christian Dillon as Vice President of Biology.

From PhoreMost 14 Jun 2021

Study elucidates how Omega-3 fatty acids poison tumor cells

So-called "good fatty acids" are essential for human health and much sought after by those who try to eat healthily. Among the Omega-3 fatty acids, DHA or docosahexaenoic acid is crucial to brain function, vision and the regulation of inflammatory phenomena.

11 Jun 2021

Scientists develop new method for single-cell lineage tracing of metastatic cancer

It's often cancer's spread, not the original tumor, that poses the disease's most deadly risk.

10 Jun 2021

Discovery suggests new pathways for safeguarding the immune system’s ability to fight cancer

In order for cancer to grow and spread, it has to evade detection by our immune cells, particularly specialized "killer" T cells.

10 Jun 2021

Major anti-cancer protein released by neutrophils selectively kills tumor cells

A study published in the June 10, 2021 issue of Cell describes a remarkable new mechanism by which the body's own immune system can eliminate cancer cells without damaging host cells.

10 Jun 2021

Researchers develop new method to make CRISPR gene editing more precise

CRISPR Researchers from Aarhus University and University of Copenhagen have developed a new method, which makes CRISPR gene editing more precise than conventional methods.

10 Jun 2021

LIM domain only 1 gene contributes to the tumorigenesis of multiple cancers

Humans have been plagued by a myriad of deadly cancers since ages. Parallelly, they have also been attempting different permutations and combinations of treatments to cure the disease. Part of these attempts involving biomolecular targets have come to the fore in recent years.

10 Jun 2021

Common antidepressant drugs help the immune system to attack tumors in mice

A class of drug called monoamine oxidase inhibitors is commonly prescribed to treat depression; the medications work by boosting levels of serotonin, the brain's "happiness hormone."

10 Jun 2021