Cell Biology

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Large scale 'proteogenomics' study could offer hope to patients with deadly pancreatic cancer

A large international collaboration led by researchers from the Johns Hopkins Kimmel Cancer Center has identified promising new targets for pancreatic cancer treatment and early diagnosis after examining various aspects of these tumors' genes and proteins.

20 Sep 2021

New discovery reveals how immune 'sentinel' cells are maintained

WEHI researchers have made a surprise discovery about how immune 'sentinel' cells are maintained, which could have implications for drugs in development for treating cancer.

20 Sep 2021

Study highlights the usefulness of organoids for basic research into coronaviruses

Researchers from the group of Hans Clevers in collaboration with the group of Bart Haagmans (Erasmus MC) established an organoid biobank to search for the genes that are essential for the spreading of a SARS-CoV2 infection.

20 Sep 2021

Researchers discover new mechanism used by a simple yeast cell to acquire its shape

Working with light to activate processes within genetically modified fission yeast cells is among the research performed by the experimental biologists in the Martin Lab at the University of Lausanne, led by faculty member Sophie Martin.

18 Sep 2021

New automated computer program can accurately count micronuclei in cells

Micronuclei, which are small nucleus-like structures within cells, are commonly associated with tumors. Now, researchers from Tsukuba, Japan have developed an automated computer program that can accurately and reproducibly count these structures from microscope images, which will increase the speed and accuracy of micronuclei research.

18 Sep 2021

GammaDelta Therapeutics initiates first-in-human phase 1 trial of GDX012 for the treatment of acute myeloid leukemia

GammaDelta Therapeutics Ltd., a biotechnology company pioneering the discovery and development of allogeneic gamma delta T cell therapies for cancer, today announced that it has initiated a first-in-human Phase I clinical trial evaluating GDX012 for the treatment of acute myeloid leukemia.

17 Sep 2021

Study offers evolutionary insights into pineal color detection system of the lamprey

Most non-mammalian vertebrates have a color detection system in the pineal organ of the brain that is located in a single cell.

17 Sep 2021

Organs-on-chips for personalized medicine and to assess drug efficacy

Organs-on-chips could be used to assess drug efficacy and support personalized medicine, write Adrian Roth and colleagues in a Perspective.

17 Sep 2021

New vaccine platform can better induce anti-malaria immunity in the liver

Malaria remains a deadly disease that affects people worldwide, particularly in Africa. Caused by a parasite that can enter the human bloodstream via mosquito bite, the parasites can then infect and reproduce within the person's liver.

16 Sep 2021

Study points to a possible new approach for treating MRSA superbug

A study released in STEM CELLS Translational Medicine, by researchers at the Baker Institute for Animal Health, part of Cornell University's College of Veterinary Medicine, Ithaca, N.Y., details in a relevant ex vivo model how treating wounds with the secretion of a type of stem cell called mesenchymal stromal cell (MSC) effectively reduced methicillin-resistant Staphylococcus aureus – better known as MRSA viability and stimulated the surrounding skin cells to build up a defense against the bacterial invader.

16 Sep 2021

Defective versions of tumor suppressor genes can help cancer cells evade the immune system

Hundreds of cancer-linked genes play a different role in causing disease than scientists had expected.

16 Sep 2021

Improving optical tissue clearing method for better cancer diagnosis

When it comes to cancer, clarity is key. The ability to visualize cancerous tumors and metastatic tissue three dimensionally (3D) can help clinicians diagnose the precise type and stage of cancer, while also informing the best treatment methods.

16 Sep 2021

Fatal COVID-19 infections linked to poor immune responses and elevated MAIT cell activation

The mortality rate of COVID-19 patients requiring mechanical ventilation is 30-40%, however, the immunological factors associated with death in critically ill COVID-19 patients are poorly understood.

16 Sep 2021

Study highlights the importance of deeply exploring the immune responses against cancer

Over the past decade, scientists have been exploring vaccination as a way to help fight cancer. These experimental cancer vaccines are designed to stimulate the body's own immune system to destroy a tumor, by injecting fragments of cancer proteins found on the tumor.

16 Sep 2021

Unique imaging technique sheds light on how cells related to IBD affect intestinal tissues

New "maps" of hundreds of thousands of cells related to inflammatory bowel disease shed greater light on their effects on intestinal tissues through a newly utilized imaging technique called "imaging mass cytometry."

16 Sep 2021

Novel cell reprogramming offers a promising therapeutic strategy to slow down glioblastomas

Gliomas are the most common primary brain tumors in adults. Among them, high-grade glioblastomas (GBMs) are particularly known to be notoriously aggressive and invasive, which makes it challenging to treat them. The disease rapidly progresses to an advanced stage in a short span of time, and the survival of such patients is often dismal.

16 Sep 2021

Study provides the most detailed view of how ribosomes are assembled in human cells

All cells need ribosomes to make the proteins necessary for life. These multi-component molecular machines build complex proteins by stitching building blocks together according to instructions encoded in the cell's messenger RNAs.

16 Sep 2021

BAK/MCL1 complex in tumor cells can predict the sensitivity of chemotherapy drugs in ovarian cancer

A research team led by Prof. DAI Haiming from the Hefei Institutes of Physical Science (HFIPS) of the Chinese Academy of Sciences (CAS) recently announced the constitutive BAK/MCL1 complexes could predict chemotherapy drugs sensitivity of ovarian cancer. The result has been published on Cell death & disease.

16 Sep 2021

New study reveals chemical steps in an important cellular modification process

The chemical steps in an important cellular modification process that adds a chemical tag to some RNAs have been revealed in a new study. Interfering with this process in humans can lead to neuronal diseases, diabetes, and cancers.

16 Sep 2021

Scientists investigate if the APOE4 gene in astrocytes relates to Alzheimer's disease

AD, the most frequent cause of dementia, affects an estimated 24 million people worldwide. With very limited treatment options, scientists are looking for ways to understand the disease better.

15 Sep 2021

Cell Biology

Large scale 'proteogenomics' study could offer hope to patients with deadly pancreatic cancer

New discovery reveals how immune 'sentinel' cells are maintained

Study highlights the usefulness of organoids for basic research into coronaviruses

Researchers discover new mechanism used by a simple yeast cell to acquire its shape

New automated computer program can accurately count micronuclei in cells

GammaDelta Therapeutics initiates first-in-human phase 1 trial of GDX012 for the treatment of acute myeloid leukemia

Study offers evolutionary insights into pineal color detection system of the lamprey

Organs-on-chips for personalized medicine and to assess drug efficacy

New vaccine platform can better induce anti-malaria immunity in the liver

Study points to a possible new approach for treating MRSA superbug

Defective versions of tumor suppressor genes can help cancer cells evade the immune system

Improving optical tissue clearing method for better cancer diagnosis

Fatal COVID-19 infections linked to poor immune responses and elevated MAIT cell activation

Study highlights the importance of deeply exploring the immune responses against cancer

Unique imaging technique sheds light on how cells related to IBD affect intestinal tissues

Novel cell reprogramming offers a promising therapeutic strategy to slow down glioblastomas

Study provides the most detailed view of how ribosomes are assembled in human cells

BAK/MCL1 complex in tumor cells can predict the sensitivity of chemotherapy drugs in ovarian cancer

New study reveals chemical steps in an important cellular modification process

Scientists investigate if the APOE4 gene in astrocytes relates to Alzheimer's disease

Real-time Raman monitoring for pharmaceutical hot melt extrusion

Synthetic Psychedelics: A Growing Public Health Concern

How the Vutara VXL simplifies single-molecule imaging

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