Cell Biology

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Study shows how SARS-CoV-2 viral proteases can be targeted to stop virus replication

Researchers at the University of Liverpool have shown how SARS-CoV-2 viral proteases attack the host cell, and how this can be targeted to stop virus replication in cell culture using existing drugs.

21 Sep 2021

Careful pipetting reduces the stress on cells in culture

Cell viability, defined as the proportion of live cells in a sample, is a fundamental consideration in all cell culture techniques.

From INTEGRA Biosciences 21 Sep 2021

Researchers uncover a molecular mechanism to inhibit aggravation of colitis

The intestinal microbial ecosystem includes diverse species of bacteria. These bacteria can produce bioactive metabolites that directly affect the host's immune system.

21 Sep 2021

Differences in DNA methylation could accurately predict progression of liver disease

Findings of a national study led by the Translational Genomics Research Institute, an affiliate of City of Hope, identify potential biomarkers that might eventually be used to diagnose progressive stages of liver disease.

20 Sep 2021

Researchers develop new method to track the development of cancer cells

Changes in individual cancer cells over time may explain why brain tumours develop so differently, and why some cancer cells are resistant to certain treatments.

20 Sep 2021

Two proteins work in tandem to build lifelines to cancer cells, study finds

In human cancer cell and mouse studies, researchers from Johns Hopkins Medicine have found that a set of proteins work in tandem to build supply lines that deliver oxygen and nutrients to tumors, enabling them to survive and grow.

20 Sep 2021

Large scale 'proteogenomics' study could offer hope to patients with deadly pancreatic cancer

A large international collaboration led by researchers from the Johns Hopkins Kimmel Cancer Center has identified promising new targets for pancreatic cancer treatment and early diagnosis after examining various aspects of these tumors' genes and proteins.

20 Sep 2021

New discovery reveals how immune 'sentinel' cells are maintained

WEHI researchers have made a surprise discovery about how immune 'sentinel' cells are maintained, which could have implications for drugs in development for treating cancer.

20 Sep 2021

Study highlights the usefulness of organoids for basic research into coronaviruses

Researchers from the group of Hans Clevers in collaboration with the group of Bart Haagmans (Erasmus MC) established an organoid biobank to search for the genes that are essential for the spreading of a SARS-CoV2 infection.

20 Sep 2021

Researchers discover new mechanism used by a simple yeast cell to acquire its shape

Working with light to activate processes within genetically modified fission yeast cells is among the research performed by the experimental biologists in the Martin Lab at the University of Lausanne, led by faculty member Sophie Martin.

18 Sep 2021

New automated computer program can accurately count micronuclei in cells

Micronuclei, which are small nucleus-like structures within cells, are commonly associated with tumors. Now, researchers from Tsukuba, Japan have developed an automated computer program that can accurately and reproducibly count these structures from microscope images, which will increase the speed and accuracy of micronuclei research.

18 Sep 2021

GammaDelta Therapeutics initiates first-in-human phase 1 trial of GDX012 for the treatment of acute myeloid leukemia

GammaDelta Therapeutics Ltd., a biotechnology company pioneering the discovery and development of allogeneic gamma delta T cell therapies for cancer, today announced that it has initiated a first-in-human Phase I clinical trial evaluating GDX012 for the treatment of acute myeloid leukemia.

17 Sep 2021

Study offers evolutionary insights into pineal color detection system of the lamprey

Most non-mammalian vertebrates have a color detection system in the pineal organ of the brain that is located in a single cell.

17 Sep 2021

Organs-on-chips for personalized medicine and to assess drug efficacy

Organs-on-chips could be used to assess drug efficacy and support personalized medicine, write Adrian Roth and colleagues in a Perspective.

17 Sep 2021

New vaccine platform can better induce anti-malaria immunity in the liver

Malaria remains a deadly disease that affects people worldwide, particularly in Africa. Caused by a parasite that can enter the human bloodstream via mosquito bite, the parasites can then infect and reproduce within the person's liver.

16 Sep 2021

Study points to a possible new approach for treating MRSA superbug

A study released in STEM CELLS Translational Medicine, by researchers at the Baker Institute for Animal Health, part of Cornell University's College of Veterinary Medicine, Ithaca, N.Y., details in a relevant ex vivo model how treating wounds with the secretion of a type of stem cell called mesenchymal stromal cell (MSC) effectively reduced methicillin-resistant Staphylococcus aureus – better known as MRSA viability and stimulated the surrounding skin cells to build up a defense against the bacterial invader.

16 Sep 2021

Defective versions of tumor suppressor genes can help cancer cells evade the immune system

Hundreds of cancer-linked genes play a different role in causing disease than scientists had expected.

16 Sep 2021

Improving optical tissue clearing method for better cancer diagnosis

When it comes to cancer, clarity is key. The ability to visualize cancerous tumors and metastatic tissue three dimensionally (3D) can help clinicians diagnose the precise type and stage of cancer, while also informing the best treatment methods.

16 Sep 2021

Fatal COVID-19 infections linked to poor immune responses and elevated MAIT cell activation

The mortality rate of COVID-19 patients requiring mechanical ventilation is 30-40%, however, the immunological factors associated with death in critically ill COVID-19 patients are poorly understood.

16 Sep 2021

Study highlights the importance of deeply exploring the immune responses against cancer

Over the past decade, scientists have been exploring vaccination as a way to help fight cancer. These experimental cancer vaccines are designed to stimulate the body's own immune system to destroy a tumor, by injecting fragments of cancer proteins found on the tumor.

16 Sep 2021

Cell Biology

Study shows how SARS-CoV-2 viral proteases can be targeted to stop virus replication

Careful pipetting reduces the stress on cells in culture

Researchers uncover a molecular mechanism to inhibit aggravation of colitis

Differences in DNA methylation could accurately predict progression of liver disease

Researchers develop new method to track the development of cancer cells

Two proteins work in tandem to build lifelines to cancer cells, study finds

Large scale 'proteogenomics' study could offer hope to patients with deadly pancreatic cancer

New discovery reveals how immune 'sentinel' cells are maintained

Study highlights the usefulness of organoids for basic research into coronaviruses

Researchers discover new mechanism used by a simple yeast cell to acquire its shape

New automated computer program can accurately count micronuclei in cells

GammaDelta Therapeutics initiates first-in-human phase 1 trial of GDX012 for the treatment of acute myeloid leukemia

Study offers evolutionary insights into pineal color detection system of the lamprey

Organs-on-chips for personalized medicine and to assess drug efficacy

New vaccine platform can better induce anti-malaria immunity in the liver

Study points to a possible new approach for treating MRSA superbug

Defective versions of tumor suppressor genes can help cancer cells evade the immune system

Improving optical tissue clearing method for better cancer diagnosis

Fatal COVID-19 infections linked to poor immune responses and elevated MAIT cell activation

Study highlights the importance of deeply exploring the immune responses against cancer

Real-time Raman monitoring for pharmaceutical hot melt extrusion

Synthetic Psychedelics: A Growing Public Health Concern

How the Vutara VXL simplifies single-molecule imaging

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