Cell Biology

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Tiny protein in mitochondria has a big impact on health and longevity, study shows

A new study led by researchers at the USC Leonard Davis School of Gerontology is the first to demonstrate that a tiny protein has a big impact on health and longevity in both animals and humans.

24 Jun 2020

Cell signaling pathway may offer new drugs for tuberous sclerosis complex

Tuberous sclerosis complex (TSC) is a neurological disorder causing non-cancerous tumors, called cortical tubers, to grow throughout the brain and body, as well as other conditions like epilepsy and autism.

24 Jun 2020

Researchers investigate nelarabine drug for treating leukemia

Acute lymphoblastic leukemia (ALL) is the most common kind of cancer in children. T-ALL, a subtype that resembles T-lymphocytes, can be treated successfully with the drug nelarabine.

24 Jun 2020

New technique helps measure dNTP concentrations with greater sensitivity

A highly sensitive and easy-to-use technique applicable for tissue samples can be useful, for example, to researchers specialised in mitochondrial diseases and cancer.

24 Jun 2020

Researchers develop less invasive genetic tools to understand cellular activity

Graduate student Ubadah Sabbagh placed a cold glass slide on the microscope. It was getting late and the lab was quiet.

24 Jun 2020

Kerafast offers the Delta-G-VSV Pseudotyping System for coronavirus research

Kerafast Inc., developers of an online platform to facilitate access to unique lab-made bioresearch materials, today announced the availability of the Delta-G-VSV Pseudotyping System for coronavirus research applications. The system, developed by the Michael Whitt laboratory at University of Tennessee, enables studies of SARS-CoV-2 viral entry and COVID-19 vaccine effectiveness at just biosafety level 2 (BSL-2) containment.

From Kerafast 24 Jun 2020

A new approach to track down cryptic peptides

Almost all cells of the human body present fragments of cellular proteins on their surface, so-called human leukocyte antigens or HLA peptides, which play an important role in the immune response.

23 Jun 2020

Scientists create hollow, spherical sacks using protein and RNA

Using protein and RNA, scientists have created hollow, spherical sacks known as vesicles.

23 Jun 2020

Blocking a pair of sugar-transporting proteins impairs lung tumor growth

Blocking a pair of sugar-transporting proteins may be a useful treatment approach for lung cancer, suggests a new study in mice and human cells published today in eLife.

23 Jun 2020

Long-term endurance training alters the activity of genes involved in metabolic health

Decades-long endurance training alters the activity of genes in human skeletal muscle that are important for metabolic health.

23 Jun 2020

Researchers develop method to assess mitochondrial respiration in frozen tissues

Scientists led by Dr. Orian Shirihai, director of the metabolism theme at the David Geffen School of Medicine at UCLA, have developed a method for restoring oxygen-consumption activity to previously frozen mitochondria samples, even years after they have been collected.

23 Jun 2020

Unexpected discovery helps explain fundamental mystery about how muscles work

Researchers at the Max Delbrück Center for Molecular Medicine in the Helmholtz Association developed a mouse model that enables them to look inside a working muscle and identify the proteins that allow the sarcomere to contract, relax, communicate its energy needs, and adapt to exercise.

21 Jun 2020

Killifish model helps unravel molecular events that lead to loss of protein homeostasis during brain aging

Aging is the main risk factor for dementia and Parkinson's disease. As age progresses, toxic protein aggregates pile up in the brain and impair neuronal function.

21 Jun 2020

Researchers discover mechanical cause for cell extrusion

The outer or inner boundaries of organs in the human body are lined with so-called epithelial sheets. These are layers of epithelial cells that can individually change their 3D shape -- which is what happens during biological processes like organ development (morphogenesis), physiological equilibrium (homeostatis) or cancer formation (carcinogenesis).

19 Jun 2020

Research team shines new light on inflammatory cell death regulator

Walter and Eliza Hall Institute researchers have made significant advances in understanding the inflammatory cell death regulatory protein MLKL and its role in disease.

19 Jun 2020

Cloning stem cells to develop treatments for Crohn's disease

For over a decade Wa Xian, research associate professor of biology and biochemistry at the University of Houston Stem Cell Center, has been perfecting technology for cloning stem cells. Now she is using it to take aim at pediatric Crohn's disease.

18 Jun 2020

Scientists substantiate the existence of concept cells in the brain

Lobachevsky University scientists together with foreign colleagues for the first time theoretically substantiated the existence of concept cells.

18 Jun 2020

Using stem cells to study the developmental effects of Neandertal DNA

Protocols that allow the transformation of human induced pluripotent stem cell (iPSC) lines into organoids have changed the way scientists can study developmental processes and enable them to decipher the interplay between genes and tissue formation, particularly for organs where primary tissue is not available.

18 Jun 2020