Cell Biology

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Researchers identify intermediate pathway that modifies synthesis and structure of cell wall

An accumulation of an unexpected intermediate of the peptidoglycan recycling pathway that is able to modulate the synthesis and structure of the cell wall, has been found by researchers at Umeå University, Sweden.

19 May 2020

Study shows how RNA editing affects the replication of COVID-19 virus

Two human deaminase enzymes edit the RNA of the SARS-CoV-2 virus when it enters a patient's body, with implications for the evolution of the virus and the spread of the infection, according to a new study.

19 May 2020

Researchers identify determining factor in luminal cancer cells

The Translational Control of Cell Cycle and Differentiation Lab at IRB Barcelona, led by ICREA researcher Raúl Méndez, has published a study in the journal Science Advances that has identified a key factor in the development of luminal breast cancer.

18 May 2020

Human immune repertoire may not commonly produce cross-neutralizing antibodies to coronaviruses

Patients infected with either severe acute respiratory syndrome coronavirus (SARS-CoV) or SARS-CoV-2 produce antibodies that bind to the other coronavirus, but the cross-reactive antibodies are not cross protective, at least in cell-culture experiments, researchers report May 17 in the journal Cell Reports.

18 May 2020

Researchers reveal the molecular biology behind Hyaline Fibromatosis Syndrome

Hyaline Fibromatosis Syndrome (HFS) is a rare but severe genetic disease that affects babies, children, and adults. Hyaline, a glassy substance, accumulates in the skin and various organs, and causes painful deformities that can lead to an early death.

18 May 2020

Fibroblasts of different pancreatic diseases exhibit distinct properties, study reveals

Fibroblasts present in different pancreatic diseases are genetically distinct and their functions are 'programmed' by the unique environment of each disease, according to new research from the University of Liverpool (UK).

18 May 2020

A new tool to study and map the intricacies of intercellular signaling

How do cells move? Why do they move? Why do some cancer cells move slowly while others move quickly, causing a cancerous tumor to metastasize and become much more difficult to treat effectively?

18 May 2020

Cigarette smoke spurs the lungs to make more SARS-CoV-2 receptors

New research from CSHL scientists suggests that cigarette smoke spurs the lungs to make more ACE2 (angiotensin-converting enzyme 2), the protein that the coronavirus responsible for COVID-19 grabs and uses to enter human cells.

18 May 2020

Mouse model helps track organism’s development from embryonic stage to adulthood

Scientists at the Stem Cell Research program at Boston Children's Hospital and Dana-Farber Cancer Institute/Harvard Medical School have devised a mouse model that lets researchers track every cell in the body, from the embryonic stage until adulthood.

15 May 2020

New study sheds light on the cause of stem cell mutations

Research from the University of Sheffield has given new insight into the cause of mutations in pluripotent stem cells and potential ways of stopping these mutations from occurring.

15 May 2020

First detailed study of the epigenetic landscape of human tumor organoids

The researcher Manel Esteller performs the first massive epigenetic characterization in organoids or 3D cancer cultures and makes the data available to the research community to facilitate new findings on tumor development and progression.

15 May 2020

Scientists describe new mechanism of cellular locomotion

Whilst the whole world is in lockdown during the current Corona crisis, certain cells within our bodies are still travelling long-distance: while this happens when you develop pneumonia, any ordinary cut on your finger will also trigger white blood cells--aka leukocytes--to instantly move out of your blood vessels into the site of inflammation.

14 May 2020

Study uncovers how the body synthesizes triglycerides

Doctors regularly warn their patients that having high levels of triglycerides, a major dietary fat, can increase the risk of heart disease, diabetes, obesity and fatty liver disease.

13 May 2020

A deep look into hormone-producing cells of the gut

Researchers from the Hubrecht Institute and Utrecht University generated an in-depth description of the human hormone-producing cells of the gut, in a large collaborative effort with other research teams. The results are presented in the scientific journal Cell on the 13th of May.

13 May 2020

First detailed study of the epigenetic landscape of human tumor organoids

Frequently, promising cancer therapies fail when applied to patients in the real clinical setting. This occurs despite many of these new treatments demonstrating promising results at the preclinical stage in the lab.

13 May 2020

Harnessing the formation of natural killer–tumor cell immunological synapse to treat solid cancers

There are immune cells in our bodies that directly destroy infected or cancer cells - they are called natural killer cells. Recently, a POSTECH research team has developed an integrative cancer therapy using adoptive natural killer cell therapy and chemotherapy.

13 May 2020