Cell Biology

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New compound blocks genetic cause of familial ALS and frontotemporal dementia

Since the ice bucket challenge went viral in 2014, raising awareness and funding for ALS research, scientists have learned much about a disease that disconnects muscles from nerves, leading to muscle atrophy and eventual death. Their ultimate goal is to create medications capable of stopping ALS in its tracks.

18 Dec 2018

Researchers discover how MAPK translocation leads to drug resistance in melanoma

Researchers have discovered that the ER translocation of MAPK leads to drug resistance in melanoma.

18 Dec 2018

Researchers propose new model to explain how neural networks communicate

The brain is organized into a network of specialized networks of nerve cells. For such a brain architecture to function, these specialized networks - each located in a different brain area - need to be able to communicate with each other.

17 Dec 2018

Inflating cells to analyze organelle structure and function

Researchers have developed a technique that enables visualization of cellular organelles at a resolution that has not previously been achievable in optical microscopy.

17 Dec 2018

New robust method for microscopically profiling tiny single cells

Many of the cell types in our bodies work in obscure ways, that science does not yet fully understand. That also goes for immune cells, which are vital for protecting us against serious diseases.

17 Dec 2018

Researchers reveal how key transcription factor keeps the immune system in check

Our immune systems defend our bodies against dangerous invaders and help clean up when damage is done. But if our bold protectors are left unsupervised, they sometimes do their jobs too well and end up harming healthy tissues.

17 Dec 2018

Getting the Most Out of the CLARITY Technique

An interview with Dr. Tim Steppe, discussing the latest advances in the CLARITY technique and his top tips for scientists using this method in their research.

From Logos Biosystems 17 Dec 2018

Montana State doctoral student receives grant for her work to improve neuroscience tool

A Montana State University doctoral student who is working on a way to improve a neuroscience tool that uses fluorescent proteins found in some jellyfish and coral has received a grant that will help fund her work.

17 Dec 2018

Geneticists discover how sex-linked disorders arise

Researchers have discovered a regulatory gene carried on the Y chromosome that determines whether a baby will be male or female and the risk of disease.

14 Dec 2018

Researchers reveal brain mechanism that drives itch-evoked scratching behavior

It's a maddening cycle that has affected us all: it starts with an itch that triggers scratching, but scratching only makes the itchiness worse.

14 Dec 2018

Exercise-induced hormone activates cells critical for bone remodeling in mice

Exercise has been touted to build bone mass, but exactly how it actually accomplishes this is a matter of debate. Now, researchers show that an exercise-induced hormone activates cells that are critical for bone remodeling in mice.

14 Dec 2018

Answering the Biggest Neurological Research Questions of Today

An interview with Dr. Peggy Taylor, discussing the biggest neurological research questions of today and how BioLegend is helping to develop new biomarkers for neurological disease.

From BioLegend 14 Dec 2018

Mammalian collagen nanofibrils become stronger and tougher with exercise

Collagen is the fundamental building block of muscles, tissues, tendons, and ligaments in mammals. It is also widely used in reconstructive and cosmetic surgery. Although scientists have a good understanding about how it behaves at the tissue-level, some key mechanical properties of collagen at the nanoscale still remain elusive.

14 Dec 2018

Researchers discover protein involved in nematode stress response

When humans experience stress, their inner turmoil may not be apparent to an outside observer. But many animals deal with stressful circumstances - overcrowded conditions, not enough food - by completely remodeling their bodies.

14 Dec 2018

Study finds drug targets for Ebola, Dengue, and Zika viruses

No drugs are currently available to treat Ebola, Dengue, or Zika viruses, which infect millions of people every year and result in severe illness, birth defects, and even death. New research from the Gladstone Institutes and UC San Francisco may finally change that. Scientists identified key ways the three viruses hijack the body's cells, and they found at least one potential drug that can disrupt this process in human cells.

13 Dec 2018

New method to visualize small-molecule interactions inside cells

Like people in a large company, proteins in cells constantly interact with each other to perform various jobs. To develop new disease therapies, researchers are trying to control these interactions with small-molecule drugs that cause specific proteins to associate more or less with their "coworkers."

13 Dec 2018

New protein complex helps embryonic stem cells to maintain their indefinite potential

Embryonic stem cells (ESCs) are the very definition of being full of potential, given that they can become any type of cell in the body. Once they start down any particular path toward a type of tissue, they lose their unlimited potential.

12 Dec 2018

Prestigious R&D 100 Award presented to Leica Microsystems

Leica Microsystems are recognized with a presitigious R&D 100 Award for their SP8 FALCON Fluorescence Lifetime Imaging (FLIM) solution.

From Leica Microsystems GmbH 12 Dec 2018

New computational model provides clearer picture of shape-changing cells' structure and mechanics

A new computational model developed by researchers from The City College of New York and Yale gives a clearer picture of the structure and mechanics of soft, shape-changing cells that could provide a better understanding of cancerous tumor growth, wound healing, and embryonic development.

11 Dec 2018

Deadly combination: Drug cocktail induces cancer cell death by switching off energy supply

A widely used diabetes medication combined with an antihypertensive drug specifically inhibits tumor growth - this was discovered by researchers from the University of Basel's Biozentrum two years ago. In a follow-up study, recently published in Cell Reports, the scientists report that this drug cocktail induces cancer cell death by switching off their energy supply.

11 Dec 2018