Cell Biology

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Salford scientists identify new drug candidate to starve and suffocate breast cancer stem cells

Scientists have identified a new drug candidate that is able starve and suffocate cancer stem cells, paving the way for new therapies to treat breast cancer patients.

8 Oct 2019

Scientists study how immune cells sense and respond to their environment to fight diseases

Scientists at the University of Dundee have carried out one of the most comprehensive studies into how immune cells sense and respond to their environment to fight infection and destroy tumors.

8 Oct 2019

Researchers determine how the colon prioritizes gas detox over energy use

Onions, cabbage, garlic. While nutritious, eating these foods can lead to an embarrassing side effect: smelly flatulence. More than just smelly, hydrogen sulfide, the chemical compound responsible for the rotten-egg aroma, is deadly if inhaled at doses of more than 700 parts per million.

7 Oct 2019

Scientists use organoid technology to achieve stable long-term cultures of mouse urothelial cells

Investigation of biological mechanisms in urothelial tissue -one of the three types of tissue that make up the urinary system- has always been very limited due to the lack of technologies that allow working with stable and long-term populations of the cells that compose it.

4 Oct 2019

Researchers develop 3D tissue models of brain tumors in a brain-mimicking microenvironment

A team of Tufts University-led researchers has developed three-dimensional human tissue culture models of pediatric and adult brain cancers in a brain-mimicking microenvironment, a significant advancement for the study of brain tumor biology and pharmacological response.

4 Oct 2019

Exploiting the weak spot in pathogenic bacteria to develop new antibiotics

Antibiotics are still the most important weapon for combatting bacterial infections. But medical science is running out of "ammunition" because of more and more frequently occurring resistances.

4 Oct 2019

Viagra enables rapid and efficient hematopoietic stem cell mobilization in mice

The combination of two clinically approved drugs--Viagra and Plerixafor--rapidly and efficiently mobilizes blood stem cells from the bone marrow into the bloodstream in mice, researchers report October 10th in the journal Stem Cell Reports.

4 Oct 2019

Rapid progress in brain organoid research prompts ethical debate

A new paper has tried to address the ethical debate surrounding human organoids by evaluating the potential risks of creating “humanized” animals

4 Oct 2019

Findings shed light on molecular reasons for early miscarriage

Researchers at Karolinska Institutet in Sweden have uncovered a chromosome-wide mechanism that keeps the gene expression of sex chromosomes in balance in our cells.

3 Oct 2019

Chemical-sensing cells in the gums protect the mouth from infections

Newly discovered chemical-sensing cells in the gums protect the mouth by standing guard against infections that damage soft tissue and destroy the bone that supports the teeth, report researchers from the Monell Chemical Senses Center in an animal study published this week in Nature Communications.

3 Oct 2019

Certain fungi increase pancreatic cancer risk, study finds

Certain fungi move from the gut to the pancreas, expand their population more than a thousand-fold, and encourage pancreatic cancer growth, a new study finds.

2 Oct 2019

Researchers observe the effects of two proteins responsible for metastasis

The research by Assoc. Prof. Nurhan özlü of Koç University Department of Molecular Biology and Genetics and her team recently published in Molecular & Cellular Proteomics has observed the effects of two proteins in the transition from the epithelial to the mesenchymal cell type, the latter of which has mobility.

2 Oct 2019

Findings could open up new research avenues into how heme tolerance occurs in humans

Most people have some idea of how important iron is to their health, but Iqbal Hamza, professor in Animal and Avian Sciences, has made his seventeen-year career at the University of Maryland all about the study of iron and heme trafficking and regulation in the body.

1 Oct 2019

High-fat diet with high fructose damages mitochondria in the liver, study shows

Researchers at Joslin Diabetes Center have found that high levels of fructose in the diet inhibit the liver's ability to properly metabolize fat.

1 Oct 2019

New study helps better understand how type 2 diabetes progresses as a disease

Researchers at Joslin Diabetes Center, an affiliate of Harvard Medical School, have unlocked the key to clearly identifying diseased beta cells in type 2 diabetes.

1 Oct 2019

US Government to fund development of a 'universal flu vaccine'

The US government is to provide up to 400 million USD in funding to develop a “universal” flu vaccination at Duke University over the next seven years.

1 Oct 2019

Cardiac cells derived from skin samples help unravel genetic underpinnings of heart function

Genome-wide association studies have uncovered more than 500 genetic variants linked to heart function, everything from heart rate to irregular rhythms that can lead to stroke, heart failure or other complications.

30 Sep 2019

Research reveals new mechanism which could lead to premature aging in mother cells

Researchers from the University of Seville and the Andalusian Center of Molecular Biology and Regenerative Medicine, have discovered a new mechanism that makes it possible to understand premature aging in cells with asymmetrical cell division, as is the case with mother cells.

30 Sep 2019

Lipid produced in response to cold helps reduce blood sugar

Researchers based in Brazil, the United States and Germany have discovered that 12-HEPE, a lipid produced in response to cold by brown adipose tissue in the human body, helps reduce blood sugar. The results of their experiments with mice pave the way for new treatments for diabetes.

27 Sep 2019

Cellular aging associated with structural changes in the brain

Telomeres are protective caps at the ends of chromosomes that become shorter with each cell division. If they become so short that the genes they protect could be damaged, the cell stops dividing and renewing.

27 Sep 2019