Cell Biology

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Study: Male and female differences in fear memory is attributed to Cdk5 gene

In a mouse model of traumatic memory, male mice recall fear-related memories better than female mice, according to a study in Biological Psychiatry. The difference between sexes was attributed to a gene important for creating fear memories and stress behavior, called cyclin dependent kinase 5, which was naturally activated in male but not in female mice.

18 Jan 2019

Study reveals potential pathway for endothelial cells to avoid apoptosis

Cell death is an important aspect of tissue homeostasis, as well as inflammation and disease pathogenesis related to infection, injury, and tumor growth.

17 Jan 2019

Beckman Coulter launches new ClearLLab 10C System for clinical flow cytometry lab

Beckman Coulter launches the ClearLLab 10C System - the first 10-colour CE-IVD panels of immunophenotyping reagents for lymphoid and myeloid lineages.

From Beckman Coulter Life Sciences - Flow Cytometry 17 Jan 2019

Scientists solve another piece of Ebola virus puzzle

A team of researchers have discovered the interaction between an Ebola virus protein and a protein in human cells that may be an important key to unlocking the pathway of replication of the killer disease in human hosts.

17 Jan 2019

Research finds decline in ketone body utilization when coronary circulation is reduced

Ketone bodies are metabolites that can be used as energy sources like glucose and fatty acids. They can be converted into acetyl-CoA, which produces energy via the Krebs cycle in the mitochondria, and are typically used as an alternative energy source during starvation, fasting, or periods of high-intensity exercise.

17 Jan 2019

Cellular protein that interacts with viruses appears to enable infection process of Zika virus

A cellular protein that interacts with invading viruses appears to help enable the infection process of the Zika virus, according to an international team of researchers who suggest this protein could be a key target in developing new therapies to prevent or treat Zika virus infection.

17 Jan 2019

How Patch Clamp Technology Can Benefit Ion Channel Research

Learn how patch clamp technology meets high-throughput to benefit ion channel research in this interview with Tim and James, Nanion.

From Nanion Technologies 16 Jan 2019

Researchers cultivate vascular organoids that perfectly mimic human blood vessels

For the first time, researchers have successfully cultivated “vascular organoids” in a petri dish that perfectly mimic real human blood vessels.

16 Jan 2019

Researchers demonstrate how manganese produces parkinsonian syndrome

Using X-ray fluorescence at synchrotrons DESY and ESRF, researchers in the Centre d'Etudes Nucléaires de Bordeaux Gradignan have demonstrated the consequences of a mutation responsible for a hereditary parkinsonian syndrome: accumulated manganese in the cells appears to disturb protein transport.

16 Jan 2019

Breast cancer cells in mice coaxed to turn into harmless fat cells

As cancer cells respond to cues in their microenvironment, they can enter a highly plastic state in which they are susceptible to transdifferentiation into a different type of cell.

16 Jan 2019

Truncal mutations study suggests new direction in origins of cancer

Cancers most commonly arise because of a series of two to five mutations in different genes that combine to cause a tumor.

16 Jan 2019

LifeTime receives fund to develop a plan to embed its vision for healthier future

Our body's cells are constantly changing. But which of these changes are healthy developments and which lead to serious diseases? This is what LifeTime, a new transnational and interdisciplinary initiative of leading European researchers, aims to discover.

16 Jan 2019

DNA may help predict potential life expectancy of a person, report scientists

Scientists say they can predict whether a person can expect to live longer or die sooner than average, by looking at their DNA.

16 Jan 2019

Scientists reveal key mechanism in worms that controls cell's response to stress

Scientists have revealed a key mechanism in worms that is involved in controlling the cell's response to stress, a study in eLife reports.

16 Jan 2019

Researchers discover how cancer cells avoid genetic meltdown

A team of scientists have shed light on how cancer cell populations avoid genetic meltdown, despite the rapid accumulation of harmful mutations.

15 Jan 2019

Researchers manipulate T cells to improve transplant success

Researchers have manipulated T cells in a way that prevents the rejection of transplanted organs, without affecting the immune system’s ability to fight microbial infection.

15 Jan 2019

Differences in geographic origin of genes may affect mitochondrial function

Differences in the geographic origin of genes may affect the function of human mitochondria--energy-generating organelles inside of cells--according to a new study.

14 Jan 2019

Scientists identify endogenous activator of sigma-1 receptors in human cells

Cells communicate through complex mechanisms that typically involve receptors and ligands that bind to them. Endogenous ligands, produced by the body, have been identified for the vast majority of cellular receptors, helping explain receptor existence and function. But in the case of sigma-1 receptors, which interact with a diverse array of psychoactive drugs, an endogenous ligand has remained elusive.

14 Jan 2019

Molecular hallmarks of tumor hypoxia across 19 cancer types discovered

Unlike healthy tissues, tumors thrive in low-oxygen environments, often acquiring the ability to resist treatment and spread to other sites in the body. Despite being a well-known cause of therapy resistance and metastasis, the impact of low oxygen, known as hypoxia, on tumor cells is poorly understood.

14 Jan 2019

UCR researchers uncover how plants sense temperature

When it gets hot outside, humans and animals have the luxury of seeking shelter in the shade or cool, air-conditioned buildings. But plants are stuck.

14 Jan 2019