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Oxidized charcoal nanoparticles can help treat COVID-19 patients

Artificial enzymes made of treated charcoal could have the power to curtail damaging levels of superoxides, radical oxygen ions that are toxic at high concentrations.

2 Jul 2020

ACTIV group assesses controlled human infection models for developing SARS-CoV-2 vaccine

In a Perspective for the New England Journal of Medicine, members of the National Institutes of Health's Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV) Vaccines Working Group assess practical considerations and prerequisites for using controlled human infection models (CHIMs), which can be used for human challenge studies, to support SARS-CoV-2 vaccine development.

2 Jul 2020

Novel microbiome-based diagnostic tool can identify liver fibrosis, cirrhosis

Chronic liver disease represents a major global public health problem affecting an estimated 844 million people, according to the World Health Organization. It is among the top causes of mortality in Australia, the UK and the United States.

2 Jul 2020

Structure of the full SARS-CoV-2 RNA genome in infected cells

The current COVID-19 pandemic caused by a single-stranded RNA virus, thought to have jumped across species barriers to infect humans, has spread rapidly across the globe infecting over 10 million individuals. The virus, now known as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the causative agent of COVID-19 disease. COVID-19 disease is a respiratory illness where symptoms can range from very mild to severe and include fever, coughing, a sore throat, and shortness of breath.

2 Jul 2020

SARS-CoV-2 infection modeling in iPSC-derived type 2 cells

The most fatal form of COVID-19 disease is acute respiratory distress syndrome (ARDS), caused by direct viral injury as well as indirect noxious effects caused by cytotoxic chemicals and inflammatory processes. A new study published on the preprint server bioRxiv* in June 2020 shows that this is partly due to the rapid onset of inflammation caused by the infection of type 2 alveolar cells with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

2 Jul 2020

Novavax SARS-CoV-2 vaccine candidate shows promise in animal models

A new study published on the preprint server bioRxiv in June 2020 shows that a candidate spike protein vaccine can induce neutralizing antibodies, antiviral T cell responses, and protection against infection.

2 Jul 2020

Repurposed drug for acute lung injury in COVID-19

Now, a new study addresses the possible use of an FDA-approved monoclonal antibody, called fostamatinib, a spleen tyrosine kinase inhibitor (SYK), to reduce the levels of mucin-1, a molecule associated with acute lung injury and acute respiratory distress syndrome (ARDS). People who have severe COVID-19 disease may develop ARDS.

2 Jul 2020

How lockdown stopped the virus in Italy

Previous studies have shown that many severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cases were tied to asymptomatic carriers or those who do not manifest symptoms of the viral infection. Now, a new study reveals that in the first Italian town hit by the virus, as much as 40 percent of the population had no symptoms of the coronavirus disease (COVID-19).

1 Jul 2020

Coronavirus immunity is higher than previously thought, study finds

Now, a team of researchers at the Karolinska Institutet and Karolinska University Hospital in Sweden has found that the number of people immune to COVID-10 may be higher than previously thought, and that antibody testing may no longer be the appropriate tool to trace it.

1 Jul 2020

Scientists find coronavirus' Achilles' heel

A team of scientists at the University of California San Francisco has found out how SARS-CoV-2, the virus that causes the coronavirus disease (COVID-19) invades proteins in the cells that serve as master regulators of key cellular processes.

1 Jul 2020

Which facemasks work best at stopping coronavirus?

A new study shows how wearing masks can prevent the spread of droplet borne infections and is an excellent preventive measure to stop the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The study titled, "Visualizing the effectiveness of face masks in obstructing respiratory jets," is published in the latest issue of the journal Physics of Fluids.

1 Jul 2020

New tool to increase accessibility for COVID-19 testing

A research group from the University of California Santa Barbara recently demonstrated a cost-effective, simple, and much less toxic method to isolate host and pathogen nucleic acids and proteins in order to streamline the detection of DNA and RNA viruses – including the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

1 Jul 2020

New Yorkers grown more hesitant about resuming normal activities, survey shows

New Yorkers continue to report much higher than normal rates of depression and anxiety, but much less than at their peak in mid-April.

1 Jul 2020

UofM/UTHSC grant competition yields 23 projects addressing COVID-19

The University of Memphis and the University of Tennessee Health Science Center are teaming up in a venture to secure a portion of federal funding allocated for COVID-19 research.

1 Jul 2020

More than one-third of excess deaths in pandemic's early months linked to other causes

Since COVID-19's spread to the United States earlier this year, death rates in the U.S. have risen significantly. But deaths attributed to COVID-19 only account for about two-thirds of the increase in March and April, according to a study published Wednesday in the Journal of the American Medical Association.

1 Jul 2020

Important new findings on T cell immunity in COVID-19

Researchers at the Karolinska University Hospital and University Hospital of Wales report that people who have recovered from asymptomatic or mild cases of coronavirus disease 2019 (COVID-19) may have long-term T-cell immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

1 Jul 2020

Blood cell damage in COVID-19 may compromise oxygen transport

Researchers in the U.S. have shown that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may alter key protein structures on red blood cells and compromise the transport and delivery of oxygen in patients with coronavirus disease 2019 (COVID-19).

1 Jul 2020

CHOP researchers receive multi-million dollar grant to study disease risk in African Americans

The National Institutes of Health announced today that researchers from Children's Hospital of Philadelphia are among the recipients of a multi-million dollar grant that focuses on the use of genomics to improve risk assessment for diverse populations and integrate the findings into clinical care.

1 Jul 2020

UMass Amherst biostatistician awarded federal grants to support research on pandemic forecasting

University of Massachusetts Amherst biostatistician Nicholas Reich has been awarded grants from the U.S. Centers for Disease Control and Prevention (CDC) and the National Institutes of Health (NIH) to support innovation and expansion in his groundbreaking pandemic forecasting work.

1 Jul 2020

Clinical-grade wearables provide continuous on-body sensing for COVID-19

Although it might be tempting to rely on your fitness tracker to catch early signs of COVID-19, Northwestern University researchers caution that consumer wearables are not sophisticated enough to monitor the complicated illness.

1 Jul 2020