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Researchers report novel approach to combat multidrug-resistant bacterial pathogens

With the threat of multidrug-resistant bacterial pathogens growing, new ideas to treat infections are sorely needed. Researchers at University of California, San Diego School of Medicine and Skaggs School of Pharmacy and Pharmaceutical Sciences report preliminary success testing an entirely novel approach -- tagging bacteria with a molecular "homing beacon" that attracts pre-existing antibodies to attack the pathogens.

7 May 2015

ViiV Healthcare initiates Phase III trial to evaluate dolutegravir and rilpivirine in HIV patients

ViiV Healthcare today announced the start of a Phase III clinical trial programme to evaluate the safety and efficacy of dolutegravir (Tivicay) and rilpivirine (Edurant) as maintenance therapy for adult patients with HIV.

6 May 2015

New guide helps doctors, nurses to identify hospital patients who may benefit from urinary catheter

What's the only thing worse than having a urinary catheter when you're in the hospital? Having one and getting a urinary tract infection (UTI) - or worse - as a result. Now, a new detailed guide gives doctors and nurses information to help decide which hospital patients may benefit from a urinary catheter - and which ones don't.

6 May 2015

New study finds high levels of HCV infection among HIV-infected people across Africa

A new study has found high levels of infection with hepatitis C (HCV) across Africa, particularly in people infected with HIV.

6 May 2015

Study shows that periodontal treatment can reduce symptoms of prostatitis

Treating gum disease reduced symptoms of prostate inflammation, called prostatitis, report researchers from Case Western Reserve University School of Dental Medicine and the Departments of Urology and Pathology at University Hospitals Case Medical Center.

6 May 2015

Protein Sciences, CTH@H to provide Flublok vaccine to home health and hospice agencies in Connecticut

Protein Sciences Corporation, along with The Connecticut Association for Healthcare at Home, announced a new partnership today that will bring Flublok influenza vaccine to home health and hospice agencies across the state. As a new affinity partner of CTH@H, Protein Sciences will make Flublok available to CTH@H member agencies for the 2015/16 flu season.

5 May 2015

Lymphatic pump treatment may fight pneumonia by enhancing efficacy of antibiotics

Lymphatic pump treatment (LPT) shows promise in managing pneumonia when combined with antibiotic treatment, according to a new study published in The Journal of the American Osteopathic Association.

5 May 2015

Manipulating endosomal traffic could be a new target for anti-HIV-1 therapies

HIV-1 replication requires the coordinated movement of the virus's components toward the plasma membrane of an immune cell, where the virions are assembled and ultimately released. A study in The Journal of Cell Biology reveals how a Rab protein that controls intracellular trafficking supports HIV-1 assembly by promoting high levels of an important membrane lipid.

5 May 2015

AIDS patients at increased risk of developing intermediate-stage AMD

Patients with acquired immunodeficiency syndrome (AIDS) have a four-fold increase in their risk of developing intermediate-stage age-related macular degeneration (AMD) compared to people of the same age who are not infected with HIV, according to results from the Longitudinal Study of the Ocular Complications of AIDS (LSOCA) presented today at the 2015 ARVO Annual Meeting in Denver, CO.

5 May 2015

Chickenpox virus can cause strokes in patients with compromised immune systems

Patients infected with human immunodeficiency virus (HIV) can, in rare cases, experience bleeding on the brain that causes a type of stroke called intracerebral hemorrhage.

5 May 2015

Researchers reveal potential mode of drug resistance in malaria parasites

Scientists have uncovered a potential mode of parasite drug resistance in malaria infection, according to a report published in The Journal of Experimental Medicine.

5 May 2015

Pneumonic plague transmission from dog to man

Pneumonic plague is a rare but life-threatening condition caused by the bacteria Yersinia pestis. Y pestis is usually carried by rodents and can be transmitted to humans through a bite from an infected rodent or rodent flea or inhalation of infectious droplets...

1 May 2015

New approach to vaccine development is 97 per cent efficacious and could eliminate shingles

A new vaccine has proven almost completely effective in preventing shingles (disease medical name: herpes zoster), an extremely painful nerve infection which affects a third of Australians; most over the age of 50.

1 May 2015

Texas Biomed scientists awarded NIH grant to develop potential HPV-based HIV vaccine

Scientists at Texas Biomedical Research Institute have begun work on a nearly $3.4 million study funded by the National Institutes of Health over the next four years to create an attenuated, or weakened, virus that is a hybrid of the papilloma virus and the human immunodeficiency virus, with the potential to jumpstart a body's immune response to develop antibodies against both viruses.

30 Apr 2015

New research-based pharmaceutical industry report provides insights on how to slow down antimicrobial resistance (AMR) and boost antibiotic R&D

Eleven IFPMA member companies are involved in the development of new antibiotics. There are currently 34 antibacterial compounds in development (19 molecules and 15 vaccines). Eight compounds are undergoing the final stages of demonstrating their efficacy, quality, and safety (phase 3 clinical trials)...

30 Apr 2015

Urine profiles provide clues to how obesity causes disease

Scientists have identified chemical markers in urine associated with body mass, providing insights into how obesity causes disease...

30 Apr 2015

Gender equality associated with safer sexual practices among young HIV-positive South African women

Young HIV positive women are more likely to practice safer sex if they have an equitable perception of gender roles, according to new research involving the University of Southampton.

30 Apr 2015

Locally procured drugs can be as effective as IQA drugs for treating MDR-TB in Pakistan

Locally-sourced antibiotics can be as effective as 'internationally quality-assured' (IQA) antibiotics for treating multidrug-resistant tuberculosis (MDR-TB) in Pakistan, and may help avoid delays in starting treatment while programmes wait for drugs to arrive from overseas, according to new research published in PLOS ONE.

30 Apr 2015

Researchers examine alternative antimicrobials to lower bacterial contamination in fresh produce

Nearly half of foodborne illnesses in the U.S. from 1998 through 2008 have been attributed to contaminated fresh produce. Prevention and control of bacterial contamination on fresh produce is critical to ensure food safety. The current strategy remains industrial washing of the product in water containing chlorine. However, due to sanitizer ineffectiveness there is an urgent need to identify alternative antimicrobials, particularly those of natural origin, for the produce industry.

30 Apr 2015

Novel approaches to fight infections presented at the Pipeline Corner at ECCMID

The European Society of Clinical Microbiology and Infectious Diseases (ESCMID) announced breaking developments in the global fight against infections – with new mechanisms and approaches presented by smaller companies in a dedicated pipeline session at the annual congress (ECCMID) in Copenhagen.

30 Apr 2015

Disease/Infection News

Researchers report novel approach to combat multidrug-resistant bacterial pathogens

ViiV Healthcare initiates Phase III trial to evaluate dolutegravir and rilpivirine in HIV patients

New guide helps doctors, nurses to identify hospital patients who may benefit from urinary catheter

New study finds high levels of HCV infection among HIV-infected people across Africa

Study shows that periodontal treatment can reduce symptoms of prostatitis

Protein Sciences, CTH@H to provide Flublok vaccine to home health and hospice agencies in Connecticut

Lymphatic pump treatment may fight pneumonia by enhancing efficacy of antibiotics

Manipulating endosomal traffic could be a new target for anti-HIV-1 therapies

AIDS patients at increased risk of developing intermediate-stage AMD

Chickenpox virus can cause strokes in patients with compromised immune systems

Researchers reveal potential mode of drug resistance in malaria parasites

Pneumonic plague transmission from dog to man

New approach to vaccine development is 97 per cent efficacious and could eliminate shingles

Texas Biomed scientists awarded NIH grant to develop potential HPV-based HIV vaccine

New research-based pharmaceutical industry report provides insights on how to slow down antimicrobial resistance (AMR) and boost antibiotic R&D

Urine profiles provide clues to how obesity causes disease

Gender equality associated with safer sexual practices among young HIV-positive South African women

Locally procured drugs can be as effective as IQA drugs for treating MDR-TB in Pakistan

Researchers examine alternative antimicrobials to lower bacterial contamination in fresh produce

Novel approaches to fight infections presented at the Pipeline Corner at ECCMID

Real-time Raman monitoring for pharmaceutical hot melt extrusion

Synthetic Psychedelics: A Growing Public Health Concern

How the Vutara VXL simplifies single-molecule imaging

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